DRSC/TRiP Functional Genomics Resources

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Protein Alignment pdm2 and HDX

DIOPT Version :10

Sequence 1:NP_723763.1 Gene:pdm2 / 34673 FlyBaseID:FBgn0004394 Length:893 Species:Drosophila melanogaster
Sequence 2:NP_653258.2 Gene:HDX / 139324 HGNCID:26411 Length:690 Species:Homo sapiens


Alignment Length:696 Identity:132/696 - (18%)
Similarity:232/696 - (33%) Gaps:246/696 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 LANNSHHQHLSTTATETAAAAATAKAAATAA---------AAATATMLLT---SPTAAT------ 55
            :::.:.....:||.|..:|...|.:.....|         .:|...:::|   ||.:::      
Human    59 MSSKNSESGTATTGTSLSAPDITVRNVVNIARPSSQQSSWTSANNDVIVTGIYSPASSSSRQGTN 123

  Fly    56 -HCLAAATSAAGVNVQITGQGVSATLNDDQLQLPANYAANVGH---------------------L 98
             |.....|.|..:.:|.|     ||.||.:.||.......|.|                     |
Human   124 KHTDTQITEAHKIPIQKT-----ATKNDTEFQLHIPVQRQVAHCKNASLLLGEKTIILSRQTSVL 183

  Fly    99 NGFNPKDNCPPVPPTSERAFEGLLRLPQIQVKQEFMESP--------PERPS-CH------PMNH 148
            |..|...|                     ..|:.:..|.        |::|| ||      |:..
Human   184 NAGNSVFN---------------------HAKKNYGNSSVQASEMTVPQKPSVCHRPCKIEPVGI 227

  Fly   149 QQA--PANS--ALATSCRGK-TILNPW------YLRPADGIGYHNYNSNNNNSGSGEINKDVSQQ 202
            |::  |.::  ||...|..| ||.:|:      .:|....:...:|...       .:..:..|:
Human   228 QRSYKPEHTGPALHNLCGQKPTIRDPYCRTQNLEIREVFSLAVSDYPQR-------ILGGNAPQK 285

  Fly   203 MTSACGGSDGQTCLPVS---------YFGMETLASVKQRQKSLPDFLIPLHEIMFQQQHHYQQRT 258
            .:||.|     .||.::         |...|.|||::.:        ||.:...::.....:...
Human   286 PSSAEG-----NCLSIAMETGDAEDEYAREEELASMRAQ--------IPSYSRFYESGSSLRAEN 337

  Fly   259 MGTLINSLP-PGLVGYPPQKTETFKSLTPPKALQHHQNNQNHQIPQN--HTGD-----------H 309
            ..|   :|| ||. ..|..:....:.::....   :||...|..|:.  ||..           .
Human   338 QST---TLPGPGR-NMPNSQMVNIRDMSDNVL---YQNRNYHLTPRTSLHTASSTMYSNTNPLRS 395

  Fly   310 SFVRHFHERDRL-IREHQLKHQQLRDV----------EEVLQEQEQDEEQEHETLRKPHVVPSEL 363
            :|..||...::| :.::|..:|...::          :..||::.|..:::..||:|        
Human   396 NFSPHFASSNQLRLSQNQNNYQISGNLTVPWITGCSRKRALQDRTQFSDRDLATLKK-------- 452

  Fly   364 EHNHHWH------GVVC--DANGHATRL----------------------LHIAPPRAGPTPLPT 398
                :|.      |.||  .....||.|                      :.:.|||.||...  
Human   453 ----YWDNGMTSLGSVCREKIEAVATELNVDCEIVRTWIGNRRRKYRLMGIEVPPPRGGPADF-- 511

  Fly   399 HQQPPVGEV--LPPNSTSFSTIVDPP----------KEPSIYEQP---APNGRHCRPANKVMRHM 448
            .:||..|.:  |.|...:...:.:..          .|.|..|:|   .||...   |:|...| 
Human   512 SEQPESGSLSALTPGEEAGPEVGEDNDRNDEVSICLSEGSSQEEPNEVVPNDAR---AHKEEDH- 572

  Fly   449 SNSPTPPSPLRSLSDCGKSFEEEELELGENCEMPQNLS----SKRQARELDSELENE-------- 501
             ::.|..:....:.|      :||.::..|.|:.|..|    ...:.:.:::|||.:        
Human   573 -HAVTTDNVKIEIID------DEESDMISNSEVEQVNSFLDYKNEEVKFIENELEIQKQKYFKLQ 630

  Fly   502 --VLDLAPPPKRLAEEQEEEKVASVNPPQPVAFAPEEM---HQALQ 542
              |..|....|...:||::..::.: ||:     .|||   |.:|:
Human   631 TFVRSLILAMKADDKEQQQALLSDL-PPE-----LEEMDFNHASLE 670

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pdm2NP_723763.1 PHA03247 <375..675 CDD:223021 45/222 (20%)
POU 691..755 CDD:197673
Homeodomain 787..843 CDD:459649
HDXNP_653258.2 HOX 4..59 CDD:197696 132/696 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 55..76 3/16 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 112..132 3/19 (16%)
homeodomain 439..495 CDD:238039 11/67 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 501..539 10/39 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 664..690 2/7 (29%)
Blue background indicates that the domain is not in the aligned region.

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