DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pdm2 and Pou2f3

DIOPT Version :9

Sequence 1:	NP_001285877.1	Gene:	pdm2 / 34673	FlyBaseID:	FBgn0004394	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	NP_001099215.1	Gene:	Pou2f3 / 116544	RGDID:	621691	Length:	430	Species:	Rattus norvegicus

Alignment Length:	464	Identity:	177/464 - (38%)
Similarity:	221/464 - (47%)	Gaps:	127/464 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   462 SDCGKSFEEEELELGENCEMPQNLSSKRQAR------ELDSELENEVLDLAPPPKRLAEEQEEEK 520
            :|...:|.:.|.....|     .|...||.:      .|...|.:....|:..|..:...|....
  Rat    21 TDARSTFGQVESGNDRN-----GLDFNRQIKTEDLGDTLQQSLSHRPCHLSQGPTMMPGNQMSGD 80

  Fly   521 VASVNPPQPVAFAPEEMHQALQLQLHSYIEMVRQLAPEAFPNPNLATQFLLQNSLQALAQFQALQ 585
            :||::|.|.:...|                                      ..||:::||...|
  Rat    81 MASLHPLQQLVLVP--------------------------------------GHLQSVSQFLLSQ 107

  Fly   586 QMKQQQREDP-LPSYSTPLAKSPLRSPSLSPVPRHSKSQQRTPPNSMTANSL---GMSSAVMTPN 646
            ....||...| |.|:  |..:|.|..|...|              .:|:.::   |:|.:.:.|:
  Rat   108 TPPGQQGLQPNLLSF--PQQQSTLLLPQTGP--------------GLTSQAVGRPGLSGSSLEPH 156

  Fly   647 TPSMQQQPQLQQSTPKPTSGLTVASAMAKLEQSPEETTDLEELEQFAKTFKQRRIKLGFTQGDVG 711
            ..:.|..|     .||...|          ....:|.|||||||:||||||||||||||||||||
  Rat   157 LEASQHLP-----GPKHLPG----------PGGNDEPTDLEELEKFAKTFKQRRIKLGFTQGDVG 206

  Fly   712 LAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLQKWLEDADSTVAKSGGGVFNINTMTSTLS 776
            ||||||||||||||||||||||||||||||||||||:|||.||:|:.:         :...||.|
  Rat   207 LAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAESSPS---------DPSASTPS 262

  Fly   777 STP--ESILGRRRKKRTSIETTVRTTLEKAFLMNCKPTSEEISQLSERLNMDKEVIRVWFCNRRQ 839
            |.|  ..:.||:|||||||||.:|.||||.|..|.||:|||||.::|:|:|:|||:|||||||||
  Rat   263 SYPTLSEVFGRKRKKRTSIETNIRLTLEKRFQDNPKPSSEEISMIAEQLSMEKEVVRVWFCNRRQ 327

  Fly   840 KEKRINPSLDLDSPTGTPL--------------SSHAFGYPPQALNMSHMQMEGGSGSFCG---- 886
            ||||||      .|..||:              |..:...||     .|..|.|...|.|.
  Rat   328 KEKRIN------CPVATPVKPPIYNSRLVSPSGSLGSLSVPP-----VHSTMPGTVTSSCSPGNN 381

  Fly   887 ---SSISSG 892
               ||..||
  Rat   382 SRPSSPGSG 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pdm2	NP_001285877.1	POU	691..755	CDD:197673	60/63 (95%)
pdm2	NP_001285877.1	Homeobox	789..842	CDD:278475	37/52 (71%)
Pou2f3	NP_001099215.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	129..180		13/79 (16%)
		POU	176..250	CDD:197673	68/73 (93%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..271		7/30 (23%)
		Homeobox	277..330	CDD:278475	37/52 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..413		12/41 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	142	1.000	Domainoid score	I4564
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003004
OrthoInspector	1	1.000	-	-		mtm9136
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11636
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.870