DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl7 and ECEL1

DIOPT Version :9

Sequence 1:	NP_001285879.1	Gene:	Nepl7 / 34671	FlyBaseID:	FBgn0032442	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_004817.2	Gene:	ECEL1 / 9427	HGNCID:	3147	Length:	775	Species:	Homo sapiens

Alignment Length:	739	Identity:	200/739 - (27%)
Similarity:	330/739 - (44%)	Gaps:	110/739 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ALWATLISLTLIGRVLANDLFSLPPATNHREEMLEDYGRFLLSTMNRTIDPCENFYEFSCGGWKK 68
            |:.|.:::|..:|.|.|.. .:.|.....|:.... ..|||.:.::.:||||::||.|:||||.:
Human    74 AILAAMLALKYLGPVAAGG-GACPEGCPERKAFAR-AARFLAANLDASIDPCQDFYSFACGGWLR 136

  Fly    69 ADLVPEQARNTSFLNAIQHKIDEQIQGFLQNATKRELEDLGVNGTTSAEIKAKQFYASCVEMKAN 133
            ...:|:.......:.||..:.:|::        :|.|...|.....:|:.|.:.|:.||::|:..
Human   137 RHAIPDDKLTYGTIAAIGEQNEERL--------RRLLARPGGGPGGAAQRKVRAFFRSCLDMREI 193

  Fly   134 LSLGYQYFME-------HDGDRLKER---NATYDWMYINFMSK--YDIYPLLALKVHY-STSSRK 185
            ..||.:..:|       .|....:||   .|.:|...:.:.::  |....|.:|.|.. ..:|.:
Human   194 ERLGPRPMLEVIEDCGGWDLGGAEERPGVAARWDLNRLLYKAQGVYSAAALFSLTVSLDDRNSSR 258

  Fly   186 FDIL-----LTLP------------SKVLAGFS--EEQLKNMTREFGLDSSAEKVKQFVENFNNL 231
            :.|.     ||||            .|:||.:.  .|::.::.....::..|:::.|..:...|:
Human   259 YVIRIDQDGLTLPERTLYLAQDEDSEKILAAYRVFMERVLSLLGADAVEQKAQEILQVEQQLANI 323

  Fly   232 TQFER-----------NLVSLAKSRNETEQLNFKEFLVKHKHDRLNWTRFFELAFNGSQESHWPV 285
            |..|.           |.|:|.:.:..|..|.:|..|          .:.|:..|:..:|   .|
Human   324 TVSEHDDLRRDVSSMYNKVTLGQLQKITPHLRWKWLL----------DQIFQEDFSEEEE---VV 375

  Fly   286 LNQLDNINDLVFFLEQTNLETLKGYIKMRELV-------------------KFYGLWKTQTKTGG 331
            |...|.:..:...:..|....|..|:..|.:|                   :..|..|.|.
Human   376 LLATDYMQQVSQLIRSTPHRVLHNYLVWRVVVVLSEHLSPPFREALHELAQEMEGSDKPQE---- 436

  Fly   332 VQSECRSLSETYFNYALLPWFIGKVFDKERRADILSVAKDIKDTFYDLLDHHTWLDEDTRSQAKT 396
            :...|...:..:|..||...|:.:.|....:|.:..:.:|||......|:...|:|.:||:.|:.
Human   437 LARVCLGQANRHFGMALGALFVHEHFSAASKAKVQQLVEDIKYILGQRLEELDWMDAETRAAARA 501

  Fly   397 KLASMDILVGYTDDLQHREVIDGVYSDINMTGNWFENLCILEGSRARIRL------RSVDKALIP 455
            ||..|.::|||.|.|...:.:|..|........:|:|  ||...|..|:|      :.|||:  .
Human   502 KLQYMMVMVGYPDFLLKPDAVDKEYEFEVHEKTYFKN--ILNSIRFSIQLSVKKIRQEVDKS--T 562

  Fly   456 LLMPTRTVNAYYADFLNLAFITIGMAQWPFYHIDFPDVLKYAGVGNIIGHEMAHGFDSYCYQYNY 520
            .|:|.:.:||||....|......|:.|...|..|||..|.|.|:|.|||||:.||:|.:..||:.
Human   563 WLLPPQALNAYYLPNKNQMVFPAGILQPTLYDPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDR 627

  Fly   521 DGKKTNWWSSASLRNFKERYRCLESQYNKFILMGVQTNGSLTSGDNIADNVGTRMAYYAFKRKTG 585
            .|...:||:.||...|..:..|:...|:.|.:...:.||..|.|:||||..|.::||:|:::
Human   628 SGNLLHWWTEASYSRFLRKAECIVRLYDNFTVYNQRVNGKHTLGENIADMGGLKLAYHAYQK--- 689

  Fly   586 DKAWL-----EKPLRGVNFNNKQLFFVKFAQTWCNGKDNGDKLRRLKTDVHAYDEFRVQGTLSNM 645
               |:     |.||..:.:.:.||||:.|||.||..:.:.....::.||.||.:.:||.|::|..
Human   690 ---WVREHGPEHPLPRLKYTHDQLFFIAFAQNWCIKRRSQSIYLQVLTDKHAPEHYRVLGSVSQF 751

  Fly   646 PEFSEAFNCKLGTEMNPLKKCVVW 669
            .||..||:|...:.|||..||.||
Human   752 EEFGRAFHCPKDSPMNPAHKCSVW 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl7	NP_001285879.1	PepO	43..669	CDD:226118	189/698 (27%)
Nepl7	NP_001285879.1	M13	52..666	CDD:189000	185/686 (27%)
ECEL1	NP_004817.2	M13	120..773	CDD:341056	186/687 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920