DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl7 and Ece1

DIOPT Version :9

Sequence 1:	NP_001285879.1	Gene:	Nepl7 / 34671	FlyBaseID:	FBgn0032442	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	XP_006239337.1	Gene:	Ece1 / 94204	RGDID:	620293	Length:	769	Species:	Rattus norvegicus

Alignment Length:	715	Identity:	199/715 - (27%)
Similarity:	308/715 - (43%)	Gaps:	144/715 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 LLSTMNRTIDPCENFYEFSCGGWKKADLVPE-QARNTSFLNAIQHKIDEQIQGFLQNATKRELED 107
            :|::|:.|:|||::|:.::||||.||:.||: .:|..:|.|..:|. ...|:..|:|:|.
  Rat   110 ILNSMDPTVDPCQDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHN-QAIIKHLLENSTA----- 168

  Fly   108 LGVNGTTSAEIKAKQFYASCVEMKANLSLGYQYFMEHDGDRLKERNATYDWMYINFMSKYDIYPL 172
                ..:.||.||:.:|.:|:.......|..:..||.. ::|...|.|..|...||..     .|
  Rat   169 ----SASEAEKKAQVYYRACMNETRIEELRAKPLMELI-EKLGGWNITGPWAKDNFQD-----TL 223

  Fly   173 LALKVHYSTS-----------------------------SRKFDILLTLPSKVLAGFSE--EQLK 206
            ..:..||.||                             ||.:.:..|...|||.|:..  .||.
  Rat   224 QVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLG 288

  Fly   207 NMTREFGLDSSAEKVKQFVENFNNLTQFERNLVSLA----KSRNETEQLNFKEFLVKHK------ 261
            .:......||...:::|.::       ||..|.::.    |.|:|.        |:.||
  Rat   289 KLLGGGDEDSIRPQMQQILD-------FETALANITIPQEKRRDEE--------LIYHKVTAAEL 338

  Fly   262 ---HDRLNWTRFFELAFNGSQESHWPVLNQLDNINDLVFFLEQTNLETLKGYIKMRE--LVKFYG 321
               ...:||..|....|       :||  :::....:|.: ::..|..:...|...:  |:..|.
  Rat   339 QTLAPAINWLPFLNAIF-------YPV--EINESEPIVVY-DKEYLRQVSTLINSTDKCLLNNYM 393

  Fly   322 LWKTQTKTGGVQSE--------------------------CRSLSETYFNYALLPWFIGKVFDKE 360
            :|....||.....:                          |.|.:|....:||.|.|:...|.::
  Rat   394 MWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAED 458

  Fly   361 RRADILSVAKDIKDTFYDLLDHHTWLDEDTRSQAKTKLASMDILVGYTDDLQHREVIDGVYSDIN 425
            .:.....:..:||..|.:.|....|:|||||..||.|..::..::||.:.:...:.:|.|::|..
  Rat   459 SKNIASEIILEIKKAFEESLSTLKWMDEDTRRSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYT 523

  Fly   426 MTGN-WFENLCILEGSRARIRLRSVDKALIPLLMPTR--------TVNAYYADFLNLAFITIGMA 481
            ...: :|||.........|:....:.||      |.|        .|||||:...|......|:.
  Rat   524 AVPDLYFENAMRFFNFSWRVTADQLRKA------PNRDQWSMTPPMVNAYYSPTKNEIVFPAGIL 582

  Fly   482 QWPFYHIDFPDVLKYAGVGNIIGHEMAHGFDSYCYQYNYDGKKTNWWSSASLRNFKERYRCLESQ 546
            |.|||....|:.|.:.|:|.::|||:.|.||....:|:.||....||.::|:..||::..|:..|
  Rat   583 QAPFYTRSSPNALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKQQTECMVQQ 647

  Fly   547 YNKFILMGVQTNGSLTSGDNIADNVGTRMAYYAFKRKTGDKAWLEK-------PLRGVNFNNKQL 604
            ||.:.:.|...||..|.|:|||||.|.:.||.|::.      |::|       |..|:..|  ||
  Rat   648 YNNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQN------WVKKNGAEQILPTLGLTSN--QL 704

  Fly   605 FFVKFAQTWCNGKDNGDKLRRLKTDVHAYDEFRVQGTLSNMPEFSEAFNCKLGTEMNPLKKCVVW 669
            ||:.|||.||:.:........|.||.|:...|||.|:|||..||||.|.|.||:.|||..||.||
  Rat   705 FFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPLGSPMNPRHKCEVW 769

Fly 670 669
Rat 770 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl7	NP_001285879.1	PepO	43..669	CDD:226118	197/713 (28%)
Nepl7	NP_001285879.1	M13	52..666	CDD:189000	192/702 (27%)
Ece1	XP_006239337.1	PepO	105..769	CDD:226118	197/713 (28%)
Ece1	XP_006239337.1	M13	118..767	CDD:189000	193/703 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920