DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl7 and ece1

DIOPT Version :9

Sequence 1:	NP_001285879.1	Gene:	Nepl7 / 34671	FlyBaseID:	FBgn0032442	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001071260.1	Gene:	ece1 / 777750	ZFINID:	ZDB-GENE-061110-100	Length:	752	Species:	Danio rerio

Alignment Length:	757	Identity:	206/757 - (27%)
Similarity:	339/757 - (44%)	Gaps:	156/757 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ALWATLISLTL------IGRVLANDLFSLPPATNHREEMLEDYGRFLLSTMNRTIDPCENFYEFS 62
            ||:..::||.|      .|..|:....|:..|              :|.:::|::|||::||.|:
Zfish    61 ALFICIVSLGLHYKESHPGLCLSEPCVSVASA--------------VLGSLDRSVDPCQDFYNFA 111

  Fly    63 CGGWKKADLVPE-QARNTSFLNAIQHKIDEQIQGFLQNATKRELEDLGVNGTTSAEIKAKQFYAS 126
            ||||.:.:.:|| ::|...|.|..:|.:         ...|..||:..:...:.||.||:.:|.:
Zfish   112 CGGWMRKNPLPEGKSRWGPFSNLWEHNM---------AVMKNLLENTSMKSLSRAEQKAQWYYQA 167

  Fly   127 CVEMKANLSLG----YQYFMEHDGDRLKERNATYDWMYINFM-------SKYDIYPLLALKVHYS 180
            |:.......||    .....:..|..||.     .|...||.       :.:...|...:.|...
Zfish   168 CMNESKIEELGAKPLQDLINQTGGWGLKG-----PWEKDNFQEVLRIVSANFRTSPFFTVFVSTD 227

  Fly   181 TSSRKFDIL------LTLPSK---VLAGFSEEQLK---NMTREFGL------DSSAEKVKQFVEN 227
            :.|...:|:      |.|||:   :....:|:.|.   |...|.|:      |:|.:.:::.:|
Zfish   228 SKSSNSNIIQVDQSGLGLPSREYYLNKTANEKYLNAYLNFLVELGVLLGGSQDTSQKMMEEIIE- 291

  Fly   228 FNNLTQFERNLVSLA---KSRNETEQLNFKEFLVKHKH-----DRLNWTRFFELAF-----NGSQ 279
                  ||..|.::.   ..|.:.|::.:|   ::.|.     ..::|..|....|     |.|:
Zfish   292 ------FETTLANITVPQVERRDEEKIYYK---IQAKELATLAPAIDWMPFLSSVFAPVELNNSE 347

  Fly   280 ESHWPVL----NQLDNINDLVFFLEQTNLETLKGYIKM---RELV-----KF-----------YG 321
                ||:    ..|..:::|:   ..||...|..|:.|   |::|     ||           ||
Zfish   348 ----PVVVYAKEYLQKVSELI---SNTNKSVLNNYMIMKVVRKMVSILDQKFQDAEQRFLEVMYG 405

  Fly   322 L-------WKTQTKTGGVQSECRSLSETYFNYALLPWFIGKVFDKERRADILSVAKDIKDTFYDL 379
            .       ||.          |.|.:::...:||...|:...|.::.:|.:..:..:||..|.|.
Zfish   406 TKKSCMPRWKL----------CVSDTDSALGFALGALFVKATFSEDSKAFVEDMVSEIKWAFEDS 460

  Fly   380 LDHHTWLDEDTRSQAKTKLASMDILVGYTDDLQHREVIDGVYSDINMTGN-WFENLCILEGSRAR 443
            |...:|:|.:|:..||.|..::..:|||...:.:.:.:|.|::|.::..: :|:|:.......||
Zfish   461 LKTVSWMDPETKKAAKEKADAIYNMVGYPKFIMNPKELDKVFNDFDVVSDLYFQNVMNYYNFSAR 525

  Fly   444 IRLRSVDKALIPLLMPTR--------TVNAYYADFLNLAFITIGMAQWPFYHIDFPDVLKYAGVG 500
            :....:.||      |.|        ||||||....|...:..|:.|.|||:..:|..:.:.|:|
Zfish   526 VTADQLRKA------PNRDQWSMTPPTVNAYYNPTKNEMVLPAGIFQAPFYNHAWPKAMNFGGIG 584

  Fly   501 NIIGHEMAHGFDSYCYQYNYDGKKTNWWSSASLRNFKERYRCLESQYNKFILMGVQTNGSLTSGD 565
            .::|||:.|.||....:|:.||....||.::|:..|:.:.:|:..||:.:.:.....||..|.|:
Zfish   585 VVMGHELTHAFDDQGRKYDKDGNLAKWWQNSSVEAFQHQTQCMVEQYSNYSINNEPLNGKHTLGE 649

  Fly   566 NIADNVGTRMAYYAFK---RKTGDKAWLEKPLRGVNFNNKQLFFVKFAQTWCNGKDNGDKLRRLK 627
            |||||.|...||.|:.   :|.|::|.|  |..|:  ||.|||||.|||.||:.:........:.
Zfish   650 NIADNGGLNAAYKAYVNWIKKNGEEASL--PALGM--NNHQLFFVGFAQVWCSVRTPESSHEGVI 710

  Fly   628 TDVHAYDEFRVQGTLSNMPEFSEAFNCKLGTEMNPLKKCVVW 669
            ||.|:...|||.||:||..||||.|.||..:.|||.:||.:|
Zfish   711 TDPHSPSRFRVIGTISNSHEFSEHFGCKADSPMNPKRKCELW 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl7	NP_001285879.1	PepO	43..669	CDD:226118	196/710 (28%)
Nepl7	NP_001285879.1	M13	52..666	CDD:189000	192/698 (28%)
ece1	NP_001071260.1	PepO	94..752	CDD:226118	196/708 (28%)
ece1	NP_001071260.1	M13	101..750	CDD:189000	193/699 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.020