DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl7 and Ecel1

DIOPT Version :9

Sequence 1:	NP_001285879.1	Gene:	Nepl7 / 34671	FlyBaseID:	FBgn0032442	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_068544.2	Gene:	Ecel1 / 60417	RGDID:	61806	Length:	775	Species:	Rattus norvegicus

Alignment Length:	734	Identity:	200/734 - (27%)
Similarity:	325/734 - (44%)	Gaps:	100/734 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ALWATLISLTLIGRVLANDLFSLPPATNHREEMLEDYGRFLLSTMNRTIDPCENFYEFSCGGWKK 68
            |:.|.:::|..:|...|....:.|.....|:.... ..|||.:.::.:||||::||.|:||||.:
  Rat    74 AILAAMLALKYLGPGAAGTGGACPEGCPERKAFAR-AARFLSANLDASIDPCQDFYSFACGGWLR 137

  Fly    69 ADLVPEQARNTSFLNAIQHKIDEQIQGFLQNATKRELEDLGVNGTTSAEIKAKQFYASCVEMKAN 133
            ...:|:.......:.||..:.:|:::..|...|.      |..|  :|:.|.:.|:.||::|:..
  Rat   138 RHAIPDDKLTYGTIAAIGEQNEERLRRLLARPTG------GPGG--AAQRKVRAFFRSCLDMREI 194

  Fly   134 LSLGYQYFME-------HDGDRLKERNATYDWMYINFMSK----YDIYPLLALKVHY-STSSRKF 186
            ..||.:..:|       .|.....:|.....|.....:.|    |....|.:|.|.. ..:|.::
  Rat   195 ERLGPRPMLEVIEDCGGWDLGGAADRPGAARWDLNRLLYKAQGVYSAAALFSLTVSLDDRNSSRY 259

  Fly   187 DIL-----LTLPSKVLAGFSEEQ-----------LKNMTREFGLDS---SAEKVKQFVENFNNLT 232
            .|.     ||||.:.|....:|:           ::.:.|..|.|:   .|:::.|..:...|::
  Rat   260 VIRIDQDGLTLPERTLYLAQDEESEKVLAAYKVFMERLLRLLGADAVEQKAQEILQLEQRLANIS 324

  Fly   233 QFE-----------RNLVSLAKSRNETEQLNFKEFLVKHKHDRLNWTRFFELAFNGSQESHWPVL 286
            ..|           .|.|:|.:.:..|..|.:|..|          .:.|:..|:..:|   .||
  Rat   325 VSEYDDLRRDVSSVYNKVTLGQLQKITPHLQWKWLL----------DQIFQEDFSEEEE---VVL 376

  Fly   287 NQLDNINDLVFFLEQTNLETLKGYIKMRELV------------KFYGLWKT---QTKTGGVQSEC 336
            ...|.:..:...:..|....|..|:..|.:|            ..:.|.|.   ..|...:...|
  Rat   377 LATDYMQQVSQLIRSTPRRILHNYLVWRVVVVLSEHLSPPFREALHELAKEMEGNDKPQELARVC 441

  Fly   337 RSLSETYFNYALLPWFIGKVFDKERRADILSVAKDIKDTFYDLLDHHTWLDEDTRSQAKTKLASM 401
            ...:..:|..||...|:.:.|....:|.:..:.:|||......|:...|:|..|::.|:.||..|
  Rat   442 LGQANRHFGMALGALFVHEHFSAASKAKVQQLVEDIKYILGQRLEELDWMDAQTKAAARAKLQYM 506

  Fly   402 DILVGYTDDLQHREVIDGVYSDINMTGNWFENLCILEGSRARIRL------RSVDKALIPLLMPT 460
            .::|||.|.|...|.:|..|........:|:|  ||...|..|:|      :.|||:  ..|:|.
  Rat   507 MVMVGYPDFLLKPEAVDKEYEFEVHEKTYFKN--ILNSIRFSIQLSVKKIRQEVDKS--TWLLPP 567

  Fly   461 RTVNAYYADFLNLAFITIGMAQWPFYHIDFPDVLKYAGVGNIIGHEMAHGFDSYCYQYNYDGKKT 525
            :.:||||....|......|:.|...|..|||..|.|.|:|.|||||:.||:|.:..||:..|...
  Rat   568 QALNAYYLPNKNQMVFPAGILQPTLYDPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDRSGNLL 632

  Fly   526 NWWSSASLRNFKERYRCLESQYNKFILMGVQTNGSLTSGDNIADNVGTRMAYYAFKRKTGDKAWL 590
            :||:.||...|..:..|:...|:.|.:...:.||..|.|:||||..|.::||||:::      |:
  Rat   633 HWWTEASYSRFLHKAECIVRLYDNFTVYNQRVNGKHTLGENIADMGGLKLAYYAYQK------WV 691

  Fly   591 -----EKPLRGVNFNNKQLFFVKFAQTWCNGKDNGDKLRRLKTDVHAYDEFRVQGTLSNMPEFSE 650
                 |.||..:.:.:.||||:.|||.||..:.:.....::.||.||.:.:||.|::|...||..
  Rat   692 REHGPEHPLHRLKYTHNQLFFIAFAQNWCIKRRSQSIYLQVLTDKHAPEHYRVLGSVSQFEEFGR 756

  Fly   651 AFNCKLGTEMNPLKKCVVW 669
            ||:|...:.|||:.||.||
  Rat   757 AFHCPKDSPMNPVHKCSVW 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl7	NP_001285879.1	PepO	43..669	CDD:226118	190/693 (27%)
Nepl7	NP_001285879.1	M13	52..666	CDD:189000	186/681 (27%)
Ecel1	NP_068544.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..51
Ecel1	NP_068544.2	M13	121..773	CDD:341056	187/682 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920