Protein Alignment Nepl7 and PHEX

DIOPT Version :10

• Sequence 1: NP_609577.2
• Gene: Nepl7 / 34671
• FlyBaseID: FBgn0032442
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: NP_000435.3
• Gene: PHEX / 5251
• HGNCID: 8918
• Length: 749
• Species: Homo sapiens
• Alignment Length: 789
• Identity: 184/789 - (23%)
• Similarity: 317/789 - (40%)
• Gaps: 196/789 - (24%)

  Fly     8 TLISLTLIGRVLANDLFSLPPATNH--REEMLEDYGRFLLSTMNRTIDPCENFYEFSCGGWKKAD 70
            ||:..|:: .:::..|.||.....:  :.|.:| ....:||.:|.::|||:||:.|:|.||...:
Human    30 TLVLGTIL-FLVSQGLLSLQAKQEYCLKPECIE-AAAAILSKVNLSVDPCDNFFRFACDGWISNN 92

  Fly    71 LVPEQARNTSFLNAIQHKIDEQIQGFLQNATKRELEDLGVNGTTSAEIKAKQFYASCVEMKANLS 135
            .:||...:......::|.:|.:::..|:.:..|..:       |.|..|||..|:||:..||
Human    93 PIPEDMPSYGVYPWLRHNVDLKLKELLEKSISRRRD-------TEAIQKAKILYSSCMNEKA--- 147

  Fly   136 LGYQYFMEHDGDRLKERNATYDWMYINFMSKYDIYPLLALKVHYS---------------TSSRK 185
                                        :.|.|..|||.:..|..               .|.||
Human   148 ----------------------------IEKADAKPLLHILRHSPFRWPVLESNIGPEGVWSERK 184

  Fly   186 FDILLTL-----------------------PSKVLAGFSEEQLKNMTREFGLDSSAEKVKQFVEN 227
            |.:|.||                       .::.:....:..|....||..||:|.| .|.:.:.
Human   185 FSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVREDYLDNSTE-AKSYRDA 248

  Fly   228 FNNLTQFERNLVSLAKSRNETE-------QLNFKEFLVKHK-------HDRLN------------ 266
            ..........|:....||.|.:       ::...|.::.|:       ::::|
Human   249 LYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEAMYNKMNISELSAMIPQFD 313

  Fly   267 WTRFFELAFNGSQESHWPVLNQLDNI--------NDLVFFLEQTNLETLKGYIKMRELV------ 317
            |..:.:...:.....|...::..:|:        .||...|.....:|:..|:..|.:.
Human   314 WLGYIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLFRILGSERKKTIANYLVWRMVYSRIPNL 378

  Fly   318 --KFYGLWKTQTKTGGVQSECRSLSE----TYFNYALLPWFIGKV-----FDKERRADILSVAKD 371
              :|...|...::.  :|.....|.:    ..|..:.||:.:||:     |.::::..:..:.:.
Human   379 SRRFQYRWLEFSRV--IQGTTTLLPQWDKCVNFIESALPYVVGKMFVDVYFQEDKKEMMEELVEG 441

  Fly   372 IKDTFYDLLD-HHTWLDEDTRSQAKTKLASMDILVGYTD----DLQHREVIDGV-YSDINMTGN- 429
            ::..|.|:|: .:.|:|..|:.:||.|..::...|||.:    |....|.:..: :|:.:..||
Human   442 VRWAFIDMLEKENEWMDAGTKRKAKEKARAVLAKVGYPEFIMNDTHVNEDLKAIKFSEADYFGNV 506

  Fly   430 -----------------------WFENLCILEGSRARIRLRSVDKALIPLLMPTRTVNAYYADFL 471
                                   ||.|                         || ||||:|:...
Human   507 LQTRKYLAQSDFFWLRKAVPKTEWFTN-------------------------PT-TVNAFYSAST 545

  Fly   472 NLAFITIGMAQWPFY-HIDFPDVLKYAGVGNIIGHEMAHGFDSYCYQYNYDGKKTNWWSSASLRN 535
            |......|..|.||: ..::|..|.|..:|.|:|||..||||:...:|:.:|....|||:.|...
Human   546 NQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWSTESEEK 610

  Fly   536 FKERYRCLESQYNKFI--LMGVQTNGSLTSGDNIADNVGTRMAYYAFKRKTGD-KAWLEKP-LRG 596
            |||:.:|:.:||:.:.  ..|:...|..|.|:|||||.|.|.|:.|:::...| :..||:| |.|
Human   611 FKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNGGLREAFRAYRKWINDRRQGLEEPLLPG 675

  Fly   597 VNFNNKQLFFVKFAQTWCNGKDNGDKLRRLKTDVHAYDEFRVQGTLSNMPEFSEAFNCKLGTEMN 661
            :.|.|.||||:.:|...||.........:::...|:..:|||.|.:||..||.:||||...:.||
Human   676 ITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQKAFNCPPNSTMN 740

  Fly   662 -PLKKCVVW 669
             .:..|.:|
Human   741 RGMDSCRLW 749

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl7	NP_609577.2	M13	52..666	CDD:341056	171/738 (23%)
PHEX	NP_000435.3	M13	74..740	CDD:341056	169/732 (23%)