DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl7 and PHEX

DIOPT Version :9

Sequence 1:	NP_001285879.1	Gene:	Nepl7 / 34671	FlyBaseID:	FBgn0032442	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_000435.3	Gene:	PHEX / 5251	HGNCID:	8918	Length:	749	Species:	Homo sapiens

Alignment Length:	789	Identity:	184/789 - (23%)
Similarity:	317/789 - (40%)	Gaps:	196/789 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 TLISLTLIGRVLANDLFSLPPATNH--REEMLEDYGRFLLSTMNRTIDPCENFYEFSCGGWKKAD 70
            ||:..|:: .:::..|.||.....:  :.|.:| ....:||.:|.::|||:||:.|:|.||...:
Human    30 TLVLGTIL-FLVSQGLLSLQAKQEYCLKPECIE-AAAAILSKVNLSVDPCDNFFRFACDGWISNN 92

  Fly    71 LVPEQARNTSFLNAIQHKIDEQIQGFLQNATKRELEDLGVNGTTSAEIKAKQFYASCVEMKANLS 135
            .:||...:......::|.:|.:::..|:.:..|..:       |.|..|||..|:||:..||
Human    93 PIPEDMPSYGVYPWLRHNVDLKLKELLEKSISRRRD-------TEAIQKAKILYSSCMNEKA--- 147

  Fly   136 LGYQYFMEHDGDRLKERNATYDWMYINFMSKYDIYPLLALKVHYS---------------TSSRK 185
                                        :.|.|..|||.:..|..               .|.||
Human   148 ----------------------------IEKADAKPLLHILRHSPFRWPVLESNIGPEGVWSERK 184

  Fly   186 FDILLTL-----------------------PSKVLAGFSEEQLKNMTREFGLDSSAEKVKQFVEN 227
            |.:|.||                       .::.:....:..|....||..||:|.| .|.:.:.
Human   185 FSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVREDYLDNSTE-AKSYRDA 248

  Fly   228 FNNLTQFERNLVSLAKSRNETE-------QLNFKEFLVKHK-------HDRLN------------ 266
            ..........|:....||.|.:       ::...|.::.|:       ::::|
Human   249 LYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEAMYNKMNISELSAMIPQFD 313

  Fly   267 WTRFFELAFNGSQESHWPVLNQLDNI--------NDLVFFLEQTNLETLKGYIKMRELV------ 317
            |..:.:...:.....|...::..:|:        .||...|.....:|:..|:..|.:.
Human   314 WLGYIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLFRILGSERKKTIANYLVWRMVYSRIPNL 378

  Fly   318 --KFYGLWKTQTKTGGVQSECRSLSE----TYFNYALLPWFIGKV-----FDKERRADILSVAKD 371
              :|...|...::.  :|.....|.:    ..|..:.||:.:||:     |.::::..:..:.:.
Human   379 SRRFQYRWLEFSRV--IQGTTTLLPQWDKCVNFIESALPYVVGKMFVDVYFQEDKKEMMEELVEG 441

  Fly   372 IKDTFYDLLD-HHTWLDEDTRSQAKTKLASMDILVGYTD----DLQHREVIDGV-YSDINMTGN- 429
            ::..|.|:|: .:.|:|..|:.:||.|..::...|||.:    |....|.:..: :|:.:..||
Human   442 VRWAFIDMLEKENEWMDAGTKRKAKEKARAVLAKVGYPEFIMNDTHVNEDLKAIKFSEADYFGNV 506

  Fly   430 -----------------------WFENLCILEGSRARIRLRSVDKALIPLLMPTRTVNAYYADFL 471
                                   ||.|                         || ||||:|:...
Human   507 LQTRKYLAQSDFFWLRKAVPKTEWFTN-------------------------PT-TVNAFYSAST 545

  Fly   472 NLAFITIGMAQWPFY-HIDFPDVLKYAGVGNIIGHEMAHGFDSYCYQYNYDGKKTNWWSSASLRN 535
            |......|..|.||: ..::|..|.|..:|.|:|||..||||:...:|:.:|....|||:.|...
Human   546 NQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWSTESEEK 610

  Fly   536 FKERYRCLESQYNKFI--LMGVQTNGSLTSGDNIADNVGTRMAYYAFKRKTGD-KAWLEKP-LRG 596
            |||:.:|:.:||:.:.  ..|:...|..|.|:|||||.|.|.|:.|:::...| :..||:| |.|
Human   611 FKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNGGLREAFRAYRKWINDRRQGLEEPLLPG 675

  Fly   597 VNFNNKQLFFVKFAQTWCNGKDNGDKLRRLKTDVHAYDEFRVQGTLSNMPEFSEAFNCKLGTEMN 661
            :.|.|.||||:.:|...||.........:::...|:..:|||.|.:||..||.:||||...:.||
Human   676 ITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQKAFNCPPNSTMN 740

  Fly   662 -PLKKCVVW 669
             .:..|.:|
Human   741 RGMDSCRLW 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl7	NP_001285879.1	PepO	43..669	CDD:226118	175/750 (23%)
Nepl7	NP_001285879.1	M13	52..666	CDD:189000	171/738 (23%)
PHEX	NP_000435.3	M13	74..747	CDD:189000	171/739 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920