DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl7 and Nep7

DIOPT Version :9

Sequence 1:	NP_001285879.1	Gene:	Nepl7 / 34671	FlyBaseID:	FBgn0032442	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_651603.1	Gene:	Nep7 / 43356	FlyBaseID:	FBgn0039564	Length:	717	Species:	Drosophila melanogaster

Alignment Length:	744	Identity:	183/744 - (24%)
Similarity:	322/744 - (43%)	Gaps:	174/744 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 TNHREEMLEDYGRFLLSTMNRTIDPCENFYEFSCGGWKKADLVPEQA--RNTSFLNAIQHKID-- 90
            |:...:.|..:|..:.|.||.::|||::||||:||.||... .|.|:  |.::.|:.....:|
  Fly    44 TDETADYLRSHGAMMKSYMNFSVDPCDDFYEFACGNWKNVK-TPRQSPHRRSNILDISYTLMDVT 107

  Fly    91 EQIQGFLQNATKREL-EDLGVNGTTSAE-IKAKQFYASCVEMKANL---------------SLGY 138
            ||:      .|:.:| |.|.|    ||| :.|::||.||  :.|.|               |||
  Fly   108 EQL------LTRTKLAEALNV----SAELLVAQRFYNSC--LAAELFPRPAADPAYLSVIRSLG- 159

  Fly   139 QYFMEHDGDRLKERNA----TYDWMYIN-FMSKYDIYPLLALK---------------------V 177
                   |....:|:|    ::.|..:: .:|.|.:..|:..:                     |
  Fly   160 -------GFPAVDRDAWNASSFSWFNMSAHLSNYGVRSLIHEEILPQHPFNPYFKLPELGFDHVV 217

  Fly   178 H----YSTSSRKFDILLTLPSKVLAGFSEEQLKNMTREFGLDSSAEKVKQFVE----------NF 228
            |    .:||||.:.:            :|.:::...:|:.|  :.:::...:|          :.
  Fly   218 HTAHVANTSSRAYQL------------NEHRMRGYLKEYNL--TKDEISAVIEGVFAFWSEALSI 268

  Fly   229 NNLTQFERNLVSLAKSRNETEQLNFKEFLVKHKHDRLNWTRFFELAFNGSQESHWPVLNQLDNIN 293
            .:..:.:|:...|.....|..:..             .|..::|:|:||           :|..|
  Fly   269 EDKFESDRDKCDLLSEIEEVPRFG-------------QWRSYYEIAWNG-----------IDFYN 309

  Fly   294 DL-------VFFLE-----QTNLETLKGYIKMRELVKFYGLWKTQTKTGGVQSECRSLSETYFNY 346
            ..       .:::|     ..:.|.:..|:.||.|.:.....|...:....:..|..:.:.....
  Fly   310 GSSGGEFCDFYYVELDKVCAKHTEAVANYLAMRFLYRMDDKLKEPKQPEDQKVNCLMIVQMTLPN 374

  Fly   347 ALLPWFIGKVFDKERRADILSVAKDIKDTFYDLLDHHTWLDEDTRSQAKTKLASMDILVGYTDDL 411
            .....::.:.|..|:.::|..:..:::.....:|:...|||.:||::|.:|.|.:..::|   ..
  Fly   375 LFNRLYMAEHFTDEKHSEISDMVTEMRKAQRQILESVEWLDAETRAEALSKEAGITPVIG---SY 436

  Fly   412 QHREVIDGVYSDINMTGNWFENLCILEGSRAR--IRLR---------------SVDKALIPL-LM 458
            ::.|:.|.:..:||       ||.|:|||.|:  |.||               .:.|...|| |:
  Fly   437 KNEELSDTLIREIN-------NLTIVEGSYAQSLINLRVLGTYLHRYAGLHADELPKDTKPLTLL 494

  Fly   459 PTRTVNAYYADFLNLAFITIGMAQWPFYHIDFPDVLKYAGVGNIIGHEMAHGFDSYCYQYNYDGK 523
            ....|||:|.:..|..::..|:...|.||..:||.||:..:|.:||||:.||||:....::..|:
  Fly   495 VGMQVNAFYYNLDNSVYVMAGVLHPPAYHRSWPDSLKFGTIGYLIGHELTHGFDTEGSSFDSAGE 559

  Fly   524 KTNWWSSASLRNFKERYRCLESQYNKFILMGV-QT-NGSLTSGDNIADNVGTRMAYYAFK----- 581
            ..:|||..|...|:||.:|....:|::::..: || .|:.|..:||||..|.|.|...::
  Fly   560 VRDWWSRKSEAVFQERAQCYVDYFNQYLIPEINQTIRGNETRDENIADAGGLRAALTGYRNHMKQ 624

  Fly   582 --RKTGDKAWL---EKPLRGVNFNNKQLFFVKFAQTWCNGKDNGDKLRRLKTDVHAYDEFRVQGT 641
              |...|...|   .:.:.|::.:.:|||||.|||.||...:.......| |..|..|::||.|.
  Fly   625 LQRSGADGETLAHKNEQMPGLDLSPEQLFFVGFAQLWCADYEPEHYWEEL-TGAHTVDKYRVLGA 688

  Fly   642 LSNMPEFSEAFNCKLGTEMNP-LKKCVVW 669
            :||..:|:|.:.|.||:.|:| .:.|.:|
  Fly   689 VSNNDDFAEVYKCPLGSPMHPKAESCRMW 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl7	NP_001285879.1	PepO	43..669	CDD:226118	179/729 (25%)
Nepl7	NP_001285879.1	M13	52..666	CDD:189000	175/717 (24%)
Nep7	NP_651603.1	PepO	60..717	CDD:226118	179/726 (25%)
Nep7	NP_651603.1	M13	66..715	CDD:189000	175/718 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454957
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850