DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl7 and MME

DIOPT Version :9

Sequence 1:	NP_001285879.1	Gene:	Nepl7 / 34671	FlyBaseID:	FBgn0032442	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_000893.2	Gene:	MME / 4311	HGNCID:	7154	Length:	750	Species:	Homo sapiens

Alignment Length:	758	Identity:	201/758 - (26%)
Similarity:	321/758 - (42%)	Gaps:	130/758 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 VNALWATLISLTLIGRVLANDLFSLPPATNHREEMLEDYGRFLLSTMNRTIDPCENFYEFSCGGW 66
            |..|..|:|::|:|......|     .......:.::...| |:..|:.|.:||.:|::::||||
Human    33 VLVLLLTIIAVTMIALYATYD-----DGICKSSDCIKSAAR-LIQNMDATTEPCTDFFKYACGGW 91

  Fly    67 KKADLVPEQARNTSFLNAIQHKIDEQIQGFLQNATKRELEDLGVNGTTSAEIKAKQFYASCVEMK 131
            .|.:::||.:......:.::.:::..::..||   :.:.||:      .|..|||..|.||:...
Human    92 LKRNVIPETSSRYGNFDILRDELEVVLKDVLQ---EPKTEDI------VAVQKAKALYRSCINES 147

  Fly   132 ANLSLGYQYFMEHDGDRLKERNATYDW------------MYINFMSKYDIYPLLALKVHYSTSSR 184
            |..|.|.:..::...|......||.:|            ......|||....|:.|.|.....:.
Human   148 AIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTAEKAIAQLNSKYGKKVLINLFVGTDDKNS 212

  Fly   185 KFDIL------LTLPSK---VLAGFSEE-------------QLKNMTREFGLDSSAEKVKQFVEN 227
            ...::      |.|||:   ...|..:|             :|........:|.:     |....
Human   213 VNHVIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEERLPIDEN-----QLALE 272

  Fly   228 FNNLTQFER---NLVSLAKSRNETEQLNFKEFLVKHKHDRLNWTRFFELAFNGSQESHWPVLNQ- 288
            .|.:.:.|:   |..:..:.||:...|..|..|.:.:::       |.|..||...|.....|:
Human   273 MNKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNN-------FSLEINGKPFSWLNFTNEI 330

  Fly   289 -------LDNINDLVFFLEQ--TNLETLKGYIKMRELVKFYGLWKTQTKTGGVQSECRSLSETY- 343
                   :.|..|:|.:..:  |.|:.:......|:|..... |:.      :.....|||.||
Human   331 MSTVNISITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLMS-WRF------IMDLVSSLSRTYK 388

  Fly   344 -----FNYAL-------LPW------------------FIGKVFDKERRADILSVAKDIKDTFYD 378
                 |..||       ..|                  ::...|..|.:..:..:...|::.|..
Human   389 ESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQ 453

  Fly   379 LLDHHTWLDEDTRSQAKTKLASMDILVGYTDDL------QHREVIDGVYSDINMTGNWFENLCIL 437
            .||..||:|.:|:.:|:.|..::...:||.||:      .:.|.::..|.:.....|..:||...
Human   454 TLDDLTWMDAETKKRAEEKALAIKERIGYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFS 518

  Fly   438 EGSRARIRLRSVDKALIPLLMPTRTVNAYYADFLNLAFITIGMAQWPFYHIDFPDVLKYAGVGNI 502
            :..:.:.....|||.  ..:.....|||:|:...|......|:.|.||:.....:.|.|.|:|.:
Human   519 QSKQLKKLREKVDKD--EWISGAAVVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMV 581

  Fly   503 IGHEMAHGFDSYCYQYNYDGKKTNWWSSASLRNFKERYRCLESQYNKF---ILMGVQTNGSLTSG 564
            ||||:.||||.....:|.||...:||:..|..||||:.:|:..||..|   :..|...||..|.|
Human   582 IGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLG 646

  Fly   565 DNIADNVGTRMAYYAFK---RKTGDKAWLEKPLRGVNFNNKQLFFVKFAQTWCNGKDNGDKLRRL 626
            :|||||.|...||.|::   :|.|:    ||.|.|::.|:|||||:.|||.||........:..:
Human   647 ENIADNGGLGQAYRAYQNYIKKNGE----EKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSI 707

  Fly   627 KTDVHAYDEFRVQGTLSNMPEFSEAFNCKLGTEMNPLKKCVVW 669
            |||||:...||:.|||.|..||||||:|:..:.|||.|||.||
Human   708 KTDVHSPGNFRIIGTLQNSAEFSEAFHCRKNSYMNPEKKCRVW 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl7	NP_001285879.1	PepO	43..669	CDD:226118	191/715 (27%)
Nepl7	NP_001285879.1	M13	52..666	CDD:189000	186/703 (26%)
MME	NP_000893.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	79..748	CDD:189000	187/702 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920