DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl7 and Nepl12

DIOPT Version :9

Sequence 1:	NP_001285879.1	Gene:	Nepl7 / 34671	FlyBaseID:	FBgn0032442	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_649924.1	Gene:	Nepl12 / 41172	FlyBaseID:	FBgn0037727	Length:	702	Species:	Drosophila melanogaster

Alignment Length:	747	Identity:	177/747 - (23%)
Similarity:	327/747 - (43%)	Gaps:	140/747 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LWATLISL-------TLIGRVLANDLFSLPPATNH--REEMLEDYGRFLLSTMNRTIDPCENFYE 60
            ||..:.::       :|:.|...:|  |...:||.  .|..|::|..|:.|.||::::|||||||
  Fly    14 LWVIVAAVLTDCEARSLVDRSENSD--SNGSSTNRSAAEYQLQEYAEFMKSYMNQSVEPCENFYE 76

  Fly    61 FSCGGWK--KAD-LVPEQARNTSFLNAIQHKIDEQIQGFLQNATKRELEDLGVNGTTSAEIK-AK 121
            ::||.::  |.| ..|....|...:......|.||:.|.:..|     |.|.|    |:|:. |:
  Fly    77 YACGNYRNVKPDRYSPGSRSNLGDVTYTLIDITEQLLGRMDLA-----EALNV----SSELAVAQ 132

  Fly   122 QFYASCVEMKANL---------------SLGYQYFMEHDGDRLKERNATYDWMYIN-FMSKYDIY 170
            :||.:|  :.|||               |:|  .|...|||..|..|  ::|:.:: .::.|...
  Fly   133 RFYNAC--LGANLHPFNAADPAYLSLIRSIG--GFPAVDGDAWKASN--FNWINMSAHLANYGAN 191

  Fly   171 PLL--ALKVHYSTSSRKFDILLTLPSKVLAGFS-----EEQL-KNMTREFGLDSSAEKVKQFVEN 227
            .|:  .|::.|     .|:....||.   .||.     ||.: :|.||.|.|:.  |::..::..
  Fly   192 GLIRETLQLRY-----PFEPYTKLPE---LGFDHIIVHEENISRNTTRAFRLNE--ERMHGYLRA 246

  Fly   228 FN-----------NLTQFERNLVSLAKSRNETEQLNFKEFLVKHKHDRLNWTRFFELAFNGSQES 281
            |.           .:..|.|:.:.:.......:....|....:.::       ::.::::|
  Fly   247 FGLPEDRIREAIAGVFAFWRDALEIPPQCEVFDPYRIKRVFPQSEY-------YYNISWSG---- 300

  Fly   282 HWPVLNQLDNINDL---VFFLEQTNL-----ETLKGYIKMRELVKFYGLWKTQTKTGGVQSECRS 338
                   |.:.|.|   .:::|...:     :.:..|:.|:.|.:|      ..|....:.:...
  Fly   301 -------LHSTNKLFCDFYYVELDKVCARHRKAVANYLAMKLLYRF------DPKLKAPRYQRNY 352

  Fly   339 LSETYF---NYALLPWFIGKVFDKERRADILSVAKDIKDTFYDLLDHHTWLDEDTRSQAKTKLAS 400
            .|.|.:   .:.....::...|.:.:|.::..:.::::.:....|:...|||.::|::|..|.:.
  Fly   353 CSVTLYQSMRFLFNKLYMANNFSEAKRLEMSEMVRELRKSLRKALEDADWLDAESRARALLKESR 417

  Fly   401 MDILVG-YTDD---------LQHREVIDGVYSDINMTGNWFENLCILEGSRARIRLRSVDKALIP 455
            :...:| :.||         :...:||:..|::.|:.   .::|.:.....:....:.:.....|
  Fly   418 IQPRIGSFQDDALSDRIIREINSLKVIEDRYAETNIN---LQHLVVQINRFSSRHFQELTNDTKP 479

  Fly   456 --LLMPTRTVNAYYADFLNLAFITIGMAQWPFYHIDFPDVLKYAGVGNIIGHEMAHGFDSYCYQY 518
              :|...:....||... |...:..|:.:.|.|....|..||:..:|.|:|||:.||||:....:
  Fly   480 QKILTGLQVGAGYYTPD-NSINVMAGVVEPPIYQRHLPISLKFGTLGFIVGHELIHGFDTTSSYF 543

  Fly   519 NYDGKKTNWWSSASLRNFKERYRCLESQYNKFILMGV--QTNGSLTSGDNIADNVGTRMAYYAFK 581
            :.:|...:..|..|.:..::|..|....|.|:.:..:  :.||..|..:|||||.|.|.|..|:
  Fly   544 DGNGHMESLLSEISQQALEDRAECYMDYYGKYQVPEISRRVNGKTTLDENIADNSGLRQALTAY- 607

  Fly   582 RKTGDKAWLEKP--------LRGVNFNNKQLFFVKFAQTWCNGKDNGDKLRRLKTDVHAYDEFRV 638
             ::..:..||.|        :.|::...:||||:.|||.:|:..:.....:.| :|||.:|:|||
  Fly   608 -RSHRQQLLEHPGQERISDAMPGLDLTPEQLFFLGFAQLFCSHYEEEHYWKGL-SDVHTFDQFRV 670

  Fly   639 QGTLSNMPEFSEAFNCKLGTEMNP-LKKCVVW 669
            .|.|||..:|..|:||.:|:.|.| .|.|.:|
  Fly   671 LGVLSNSEDFFHAYNCSVGSGMRPGAKTCRLW 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl7	NP_001285879.1	PepO	43..669	CDD:226118	165/698 (24%)
Nepl7	NP_001285879.1	M13	52..666	CDD:189000	160/686 (23%)
Nepl12	NP_649924.1	M13	68..700	CDD:189000	160/687 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454958
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6404
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.800