DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl7 and Nepl5

DIOPT Version :9

Sequence 1:	NP_001285879.1	Gene:	Nepl7 / 34671	FlyBaseID:	FBgn0032442	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_609022.1	Gene:	Nepl5 / 33892	FlyBaseID:	FBgn0031808	Length:	684	Species:	Drosophila melanogaster

Alignment Length:	756	Identity:	172/756 - (22%)
Similarity:	293/756 - (38%)	Gaps:	167/756 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LISLTLIGRVLANDLFSL-----PPA---TNHREEMLEDYGRFLLSTMNRTIDPCENFYEFSCGG 65
            ::.|:|:..:    :|||     |.|   ||..:.:.|.....|.|.|:....||||||:::||.
  Fly     1 MLKLSLVAWL----IFSLAWRTTPTACRQTNAPQSVQEMLAEQLQSYMDTKARPCENFYQYACGN 61

  Fly    66 W----------KKADLVPEQAR------NTSFLNAIQHKIDEQIQGFLQNATKRELEDLGVNGTT 114
            |          :..|...::.|      .|..|..|.|.::.:::..|:...:...|     ..:
  Fly    62 WQIQQQEQHSLRDRDWTRDRQRYQGQMLPTDTLGLIDHSVNRKLELLLRRRNESSFE-----SDS 121

  Fly   115 SAEIKAKQFYASCVEMKA-NLSLGYQYFMEHDGDRLKERNAT-------------YDWMYINFMS 165
            |...:.:.:|.||..:|. ||....|.        |...|:|             :||  |..:.
  Fly   122 SILEQMRLYYRSCKRLKPYNLKKYLQL--------LPPSNSTQWPSVGRGWRPERFDW--ITTLG 176

  Fly   166 KYDIYPLLALKVHYST-----SSRKFDILLTLPSKVLAGFSEEQLKNMTREFGLDSSAE---KVK 222
            :..::.|..:.:....     .||.:.|.:..||           :..|:..|..:..|   .:.
  Fly   177 RLRLHGLNGVLLREEVLPRWDDSRNYSIYVNKPS-----------RQETQPMGEGAMIELLLDIG 230

  Fly   223 QFVENFNNLTQ----FERNLVSLAKSRNE----TEQLNFKEFLVKHKHDRLNWTRFF-------E 272
            |.....|.|.:    |||.|..|.:..::    ..||.:.:..:    .:|.|..|.       |
  Fly   231 QTKRTANALARQVDDFERKLHRLQELEDDEGPREMQLGYLDSYL----PQLRWLSFMRQVRIDSE 291

  Fly   273 LAFNGSQESHWPVLNQLDNINDLVFFLEQTNLETLKGYIKMRELVKFYGLWKTQTKTGGVQSECR 337
            |....:.     ::..:..:..|...:|..:.:|:..||    ::|:....|.|......:.||.
  Fly   292 LDLRSTL-----IIENIPYLRALSDLMESESPDTVCSYI----MLKWLAFLKQQGPADISRGECV 347

  Fly   338 SLSETYFNYALLPWFIGKVF-DKERRADILSVAKDIKDTFYDLL-DHHTWLDEDTRSQAKTKLAS 400
            :........| ..|.:|:.| |.|..:.:.|:.:.:|..|..:| ::...|........:.||.:
  Fly   348 AALRRAMPLA-SSWLVGQQFSDPESESYVSSLFQRLKVRFGQILAENRMRLSPPLVHILQQKLRA 411

  Fly   401 MDILVGY--TDDLQHREVIDGVYSDINMTGNWF--ENLCILEGSRARIR-------------LRS 448
            :.:.:|:  |:::   |.::..:..|:::|:.|  ..|.:|   |.|:.             ..|
  Fly   412 VRLQMGFFQTEEI---EDVEQYHVRIDLSGHSFYGNQLVLL---RQRVEANHDLLYINVTNFANS 470

  Fly   449 VDKALIPLLMPTRTVNA--YYADFLNLAFITIGMAQWPFYHIDFPDVLKYAGVGNIIGHEMAHGF 511
            ....|..|.......|:  .|....||..:..|:.|.|.:|.:...:.::|.:|.::.||:||||
  Fly   471 TGSNLSYLSESWEASNSSPLYVRPRNLVLVPHGLLQLPIWHRNISALQQHAVMGFVLAHELAHGF 535

  Fly   512 DSYCYQY----NYDGKKTNWWSSASLRNFKERYRCLESQYNKFILMGVQTNGSLTSGDNIADNVG 572
            |.....|    |..|......:|   |.|::..:||:.|         ...||....:.:||.|.
  Fly   536 DMLGMDYDAMGNIMGPVEEIGAS---RQFRQGLQCLQQQ---------MATGSKWIDEKLADFVA 588

  Fly   573 TRMAYYAF-----KRKTGDKAWLEKPLRGVNFNNKQLFFVKFAQTWCNG----KDNGDKLRRLKT 628
            .|:||..|     ||:..|      ||. ..|:.:||||:.|||.:|..    .........||
  Fly   589 LRLAYETFFGVRDKREPRD------PLL-PQFSQRQLFFITFAQFFCGRTPVLSPRSQSEAHLK- 645

  Fly   629 DVHAYDEFRVQGTLSNMPEFSEAFNCKLGTEMNPLKKCVVW 669
              ||.||.||..||:|..|||..|.|....:|...::|.:|
  Fly   646 --HAADELRVMQTLANFEEFSREFGCDKKAKMQASQRCRIW 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl7	NP_001285879.1	PepO	43..669	CDD:226118	161/712 (23%)
Nepl7	NP_001285879.1	M13	52..666	CDD:189000	157/700 (22%)
Nepl5	NP_609022.1	PepO	42..684	CDD:226118	160/709 (23%)
Nepl5	NP_609022.1	GluZincin	48..682	CDD:301352	157/701 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469674
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	1	1.000	-	-		FOG0006719
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850