DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl7 and Mmel1

DIOPT Version :9

Sequence 1:	NP_001285879.1	Gene:	Nepl7 / 34671	FlyBaseID:	FBgn0032442	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_038811.2	Gene:	Mmel1 / 27390	MGIID:	1351603	Length:	766	Species:	Mus musculus

Alignment Length:	750	Identity:	191/750 - (25%)
Similarity:	344/750 - (45%)	Gaps:	131/750 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 TLISLTLIGRVLANDLFSLPPATNHREEMLEDYGRFLLSTMNRTIDPCENFYEFSCGGWKKADLV 72
            |::...|....|.:|:.:.|........:||:        |:::.:||||||:::||||.:..::
Mouse    60 TVVKRALRDSSLKSDICTTPSCVIAAARILEN--------MDQSRNPCENFYQYACGGWLRHHVI 116

  Fly    73 PEQARNTSFLNAIQHKIDEQIQGFLQNATKRELEDLGVNGTTSAEIKAKQFYASCVEM------- 130
            ||.....|..:.::.:::..::|.|:::|.:.         ..|..|||..|.||:..
Mouse   117 PETNSRYSVFDILRDELEVILKGVLEDSTSQH---------RPAVEKAKTLYRSCMNQSVIEKRD 172

  Fly   131 -------------------KANLSLGYQYFMEHDGDRLKERNATYD---------WMYINFMSKY 167
                               |.|.::|.::.:|.   :|...|:.::         |......|::
Mouse   173 SEPLLSVLKMVGGWPVAMDKWNETMGLKWELER---QLAVLNSQFNRRVLIDLFIWNDDQNSSRH 234

  Fly   168 DIY---PLLAL--KVHYSTSSRKFDI---LLTLPSKVLAGFSEEQLKNMTREFGL--DSSAEKVK 222
            .||   |.|.:  :.:|........:   .|...:.|.....::|  |:::|..:  :..|| |.
Mouse   235 VIYIDQPTLGMPSREYYFQEDNNHKVRKAYLEFMTSVATMLRKDQ--NLSKESAMVREEMAE-VL 296

  Fly   223 QFVENFNNLT--QFERNLVSLAKSRNETEQLNFKEFLVKHKHDRLNWTRFFELAFNGSQESHWP- 284
            :...:..|.|  |.:|:.|:....|.:..:|. :.|.:|    ..|||.|.:...:..:...:|
Mouse   297 ELETHLANATVPQEKRHDVTALYHRMDLMELQ-ERFGLK----GFNWTLFIQNVLSSVEVELFPD 356

  Fly   285 ------VLNQLDNINDLVFFLEQTNLETLKGYIKMRELVKFYGLWKTQTKTGGVQ---------- 333
                  .:..|:|:.|::   :..:..|::.|:..|.::...|....:.|...|.
Mouse   357 EEVVVYGIPYLENLEDII---DSYSARTMQNYLVWRLVLDRIGSLSQRFKEARVDYRKALYGTTV 418

  Fly   334 -----SECRSLSETYFNYALLPWFIGKVFDKERRADILSVAKDIKDTFYDLLDHHTWLDEDTRSQ 393
                 .||.|...:....|:...:|.:.|.|:.::.:..:.:.|:..|.|.||...|:||:::.:
Mouse   419 EEVRWRECVSYVNSNMESAVGSLYIKRAFSKDSKSTVRELIEKIRSVFVDNLDELNWMDEESKKK 483

  Fly   394 AKTKLASMDILVGYTDDL--QHREVIDGVYSDINMTGNWFENLCILEG--------SRARIRLR- 447
            |:.|..::...:||.|.:  .:.:.:|..||.:    .::|:|....|        .|:..:||
Mouse   484 AQEKAMNIREQIGYPDYILEDNNKHLDEEYSSL----TFYEDLYFENGLQNLKNNAQRSLKKLRE 544

  Fly   448 SVDKALIPLLMPTRTVNAYYADFLNLAFITIGMAQWPFYHIDFPDVLKYAGVGNIIGHEMAHGFD 512
            .||:.|  .::....|||:|:...|......|:.|.||:..|.|..|.:.|:|.:||||:.||||
Mouse   545 KVDQNL--WIIGAAVVNAFYSPNRNQIVFPAGILQPPFFSKDQPQSLNFGGIGMVIGHEITHGFD 607

  Fly   513 SYCYQYNYDGKKTNWWSSASLRNFKERYRCLESQYNKF---ILMGVQTNGSLTSGDNIADNVGTR 574
            .....::.:|...:|||:.|.|:|:::.:|:..||..|   :......||..|.|:|||||.|.|
Mouse   608 DNGRNFDKNGNMLDWWSNFSARHFQQQSQCMIYQYGNFSWELADNQNVNGFSTLGENIADNGGVR 672

  Fly   575 MAYYAFKRKTGDKAWL-----EKPLRGVNFNNKQLFFVKFAQTWCNGKDNGDKLRRLKTDVHAYD 634
            .||.|:.|      ||     ::.|.|:|....||||:.:||.||........::.:|||||:..
Mouse   673 QAYKAYLR------WLADGGKDQRLPGLNLTYAQLFFINYAQVWCGSYRPEFAVQSIKTDVHSPL 731

  Fly   635 EFRVQGTLSNMPEFSEAFNCKLGTEMNPLKKCVVW 669
            ::||.|:|.|:|.|||||:|..|:.|:|:|:|.:|
Mouse   732 KYRVLGSLQNLPGFSEAFHCPRGSPMHPMKRCRIW 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl7	NP_001285879.1	PepO	43..669	CDD:226118	183/713 (26%)
Nepl7	NP_001285879.1	M13	52..666	CDD:189000	181/701 (26%)
Mmel1	NP_038811.2	PepO	89..766	CDD:226118	185/719 (26%)
Mmel1	NP_038811.2	M13	97..764	CDD:189000	181/701 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020