DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl7 and Phex

DIOPT Version :9

Sequence 1:	NP_001285879.1	Gene:	Nepl7 / 34671	FlyBaseID:	FBgn0032442	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_037136.2	Gene:	Phex / 25512	RGDID:	3323	Length:	749	Species:	Rattus norvegicus

Alignment Length:	751	Identity:	173/751 - (23%)
Similarity:	297/751 - (39%)	Gaps:	192/751 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 LLSTMNRTIDPCENFYEFSCGGWKKADLVPEQARNTSFLNAIQHKIDEQIQGFLQNATKRELEDL 108
            ::|.:|.::||||||:.|:|.||...:.:||...:......::|.:|.:::..|:.:..|..:
  Rat    66 IMSKVNLSVDPCENFFRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKLKALLEKSVSRRRD-- 128

  Fly   109 GVNGTTSAEIKAKQFYASCVEMKANLSLGYQYFMEHDGDRLKERNATYDWMYINFMSKYDIYPLL 173
                 |.|..|||..|:||:..||                               :.|.|..|||
  Rat   129 -----TEAVQKAKILYSSCMNEKA-------------------------------IEKADAKPLL 157

  Fly   174 ALKVHYS---------------TSSRKFDILLTL-----------------------PSKVLAGF 200
            .:..|..               .|.|||.:|.||                       .::.:...
  Rat   158 HILRHSPFRWPVLEANIGPEGVWSERKFSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEHILKL 222

  Fly   201 SEEQLKNMTREFGLDSSAEKVKQFVENFNNLTQFERNLVSLAKSRNETE-------QLNFKEFLV 258
            .:..|....||..||::.| .|.:.:...........|:....||.|.:       ::...|.::
  Rat   223 DQATLSLAVREDFLDNTTE-AKSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMI 286

  Fly   259 KHK-------HDRLN------------WTRFFELAFNGSQESHWPVLNQLDNI--------NDLV 296
            .|:       ::::|            |..:.:...:.....|...:...:|:        .||.
  Rat   287 PHENRTSEAMYNKMNISELSAMIPQFDWLGYIKKVIDTRLYPHLKDIGPSENVVVRVPQYFKDLF 351

  Fly   297 FFLEQTNLETLKGYIKMRELV--------KFYGLWKTQTKTGGVQSECRSLSE----TYFNYALL 349
            ..|.....:|:..|:..|.:.        :|...|...::.  :|.....|.:    ..|..:.|
  Rat   352 RILGAERKKTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRV--IQGTTTLLPQWDKCVNFIESAL 414

  Fly   350 PWFIGKV-----FDKERRADILSVAKDIKDTFYDLLD-HHTWLDEDTRSQAKTKLASMDILVGYT 408
            |:.:||:     |.::::..:..:.:.::..|.|:|: .:.|:|..|:.:|:.|..::...|||.
  Rat   415 PYVVGKMFVNVHFQEDKKEMMEELIEGVRWAFIDMLEKENEWMDAGTKRKAQEKARAVLAKVGYP 479

  Fly   409 D----DLQHREVIDGV-YSDINMTGN------------------------WFENLCILEGSRARI 444
            :    |....|.:..: :|:.:..||                        ||.|
  Rat   480 EFIMNDTYVNEDLKAIKFSESDYFGNVLQTRKYLAQSDFFWLRKAVPKTEWFTN----------- 533

  Fly   445 RLRSVDKALIPLLMPTRTVNAYYADFLNLAFITIGMAQWPFY-HIDFPDVLKYAGVGNIIGHEMA 508
                          || ||||:|:...|......|..|.||: ..::|..|.|..:|.|:|||..
  Rat   534 --------------PT-TVNAFYSASTNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFT 583

  Fly   509 HGFDSYCYQYNYDGKKTNWWSSASLRNFKERYRCLESQYNKFI--LMGVQTNGSLTSGDNIADNV 571
            ||||:...:|:.:|....|||..|...|||:.:|:.:||:.:.  ..|:...|..|.|:|||||.
  Rat   584 HGFDNNGRKYDKNGNLDPWWSVDSEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNG 648

  Fly   572 GTRMAYYAFKRKTGD-KAWLEKP-LRGVNFNNKQLFFVKFAQTWCNGKDNGDKLRRLKTDVHAYD 634
            |.|.|:.|:::...| :..:|:| |.|:.|.|.||||:.:|...||.........:::...|:..
  Rat   649 GLREAFRAYRKWINDRRQGVEEPLLPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPP 713

  Fly   635 EFRVQGTLSNMPEFSEAFNCKLGTEMN-PLKKCVVW 669
            :|||.|.:||..||.:||||...:.|| ....|.:|
  Rat   714 QFRVNGAISNFEEFQKAFNCPANSTMNRGADSCRLW 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl7	NP_001285879.1	PepO	43..669	CDD:226118	172/749 (23%)
Nepl7	NP_001285879.1	M13	52..666	CDD:189000	169/738 (23%)
Phex	NP_037136.2	M13	74..740	CDD:341056	167/732 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920