DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl7 and Mme

DIOPT Version :9

Sequence 1:	NP_001285879.1	Gene:	Nepl7 / 34671	FlyBaseID:	FBgn0032442	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_036740.1	Gene:	Mme / 24590	RGDID:	3098	Length:	750	Species:	Rattus norvegicus

Alignment Length:	763	Identity:	201/763 - (26%)
Similarity:	326/763 - (42%)	Gaps:	140/763 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 VNALWATLISLTLIGRVLANDLFSLPPATNHREEMLEDYGRFLLSTMNRTIDPCENFYEFSCGGW 66
            |..|..|:|::|:|......|     .......:.::...| |:..|:.:.:||.:|::::||||
  Rat    33 VLVLLLTIIAVTMIALYATYD-----DGICKSSDCIKSAAR-LIQNMDASAEPCTDFFKYACGGW 91

  Fly    67 KKADLVPEQARNTSFLNAIQHKIDEQIQGFLQNATKRELEDLGVNGTTSAEIKAKQFYASCVEMK 131
            .|.:::||.:...|..:.::.:::..::..||   :.:.||:      .|..|||..|.||:...
  Rat    92 LKRNVIPETSSRYSNFDILRDELEVILKDVLQ---EPKTEDI------VAVQKAKTLYRSCINES 147

  Fly   132 ANLSLGYQYFMEHDGDRLKERNATYDW------------MYINFMSKYDIYPLLALKVHYSTSSR 184
            |..|.|.|..:....|......|:.:|            ......|||....|:...|.....:.
  Rat   148 AIDSRGGQPLLTLLPDIYGWPVASQNWEQTYGTSWTAEKSIAQLNSKYGKKVLINFFVGTDDKNS 212

  Fly   185 KFDIL------LTLPSK---VLAGFSEE-------------QLKNMTREFGLDSSAEKVKQFVEN 227
            ...|:      |.|||:   ...|..:|             :|....:...:|.:     |....
  Rat   213 TQHIIHFDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEQRLPIDEN-----QLSLE 272

  Fly   228 FNNLTQFER---NLVSLAKSRNETEQLNFKEFLVKHKHDRLNWTRFFELAFNGSQESHW------ 283
            .|.:.:.|:   |..:..:.||:...|..|..|.|.:::       |.|..||...| |
  Rat   273 MNKVMELEKEIANATTKPEDRNDPMLLYNKMTLAKLQNN-------FSLEINGKPFS-WSNFTNE 329

  Fly   284 ---------------------------PVLNQ-----LDN------INDLVFFLEQTNLETLKGY 310
                                       |:|.:     |.|      |.|||..|.:...|:...:
  Rat   330 IMSTVNINIQNEEEVVVYAPEYLTKLKPILTKYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAF 394

  Fly   311 IKMRELVKFYGLWKTQTKTGGVQSECRSLSETYFNYALLPWFIGKVFDKERRADILSVAKDIKDT 375
            .|        .|:.|.::| .....|.:........|:...::...|..|.:..:..:...|::.
  Rat   395 RK--------ALYGTTSET-ATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREV 450

  Fly   376 FYDLLDHHTWLDEDTRSQAKTKLASMDILVGYTDD-LQHREVIDGVYSDIN-MTGNWFENLCILE 438
            |...||..||:|.:|:.:|:.|..::...:||.|| :.:...::..|.::| ....:|||  |::
  Rat   451 FIQTLDDLTWMDAETKKKAEEKALAIKERIGYPDDIISNENKLNNEYLELNYKEEEYFEN--IIQ 513

  Fly   439 G-----SRARIRLR-SVDKALIPLLMPTRTVNAYYADFLNLAFITIGMAQWPFYHIDFPDVLKYA 497
            .     |:...:|| .|||.  ..:.....|||:|:...|......|:.|.||:.....:.|.|.
  Rat   514 NLKFSQSKQLKKLREKVDKD--EWISGAAVVNAFYSSGRNQIVFPAGILQPPFFSARQSNSLNYG 576

  Fly   498 GVGNIIGHEMAHGFDSYCYQYNYDGKKTNWWSSASLRNFKERYRCLESQYNKF---ILMGVQTNG 559
            |:|.:||||:.||||.....:|.||...:||:..|..|||::.:|:..||..|   :..|...||
  Rat   577 GIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSANNFKDQSQCMVYQYGNFTWDLAGGQHLNG 641

  Fly   560 SLTSGDNIADNVGTRMAYYAFK---RKTGDKAWLEKPLRGVNFNNKQLFFVKFAQTWCNGKDNGD 621
            ..|.|:|||||.|...||.|::   :|.|:    ||.|.|::.|:|||||:.|||.||.......
  Rat   642 INTLGENIADNGGIGQAYRAYQNYVKKNGE----EKLLPGLDLNHKQLFFLNFAQVWCGTYRPEY 702

  Fly   622 KLRRLKTDVHAYDEFRVQGTLSNMPEFSEAFNCKLGTEMNPLKKCVVW 669
            .:..:|||||:...||:.|||.|..||::||:|:..:.|||.:||.||
  Rat   703 AVNSIKTDVHSPGNFRIIGTLQNSAEFADAFHCRKNSYMNPERKCRVW 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl7	NP_001285879.1	PepO	43..669	CDD:226118	191/720 (27%)
Nepl7	NP_001285879.1	M13	52..666	CDD:189000	187/708 (26%)
Mme	NP_036740.1	Stop-transfer sequence. /evidence=ECO:0000255	16..23
Mme	NP_036740.1	M13	79..748	CDD:341056	188/707 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020