DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl7 and Kel

DIOPT Version :9

Sequence 1:	NP_001285879.1	Gene:	Nepl7 / 34671	FlyBaseID:	FBgn0032442	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_115929.3	Gene:	Kel / 23925	MGIID:	1346053	Length:	713	Species:	Mus musculus

Alignment Length:	766	Identity:	189/766 - (24%)
Similarity:	309/766 - (40%)	Gaps:	172/766 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVNALWATLISLTLIGRVLANDLF---------SLPPATNHREEMLEDYGRFLLSTMNRTIDPCE 56
            :..|.| .|:::.|.|.:|.:.:.         ..|..|....|:|:.|    |::.||::.||.
Mouse    23 LTRARW-VLLAVLLCGLLLGSSMLWFYIFRNCGPCPCETPVCMELLDHY----LASGNRSVAPCT 82

  Fly    57 NFYEFSCGGWKKADLVPEQARNTSFLNAIQHKIDEQIQGFLQNATKRELEDLGVNGTTSAEIKAK 121
            :|:.|:|          |:|..||  ::.|...:|.     ::...|.||..|.....|.|.||.
Mouse    83 DFFSFAC----------EKANGTS--DSFQALTEEN-----KSRLWRLLEAPGSWHLGSGEEKAF 130

  Fly   122 QFYASCVEMKANLSLGYQYFMEHDG--------DRLKERNATYDWMYINF-------MSKYDIYP 171
            |||.||::..|         :|..|        :.|...|.|.:|..::|       ||:|..:|
Mouse   131 QFYNSCMDTDA---------IEASGSGPLIQIIEELGGWNITGNWTSLDFNQNLRLLMSQYGHFP 186

  Fly   172 LLA--LKVH--------YSTSSRKFDILL--TLPSKVLAGFSEEQLKNMTREFG--LDSSAEKVK 222
            ...  |:.|        ......:|||||  ....||.|....|.:..:.| .|  |.|:.::.:
Mouse   187 FFRAYLRPHPAPPHTPIIQIDQPEFDILLQQEQEQKVYAQILREYVTYLNR-LGTLLGSNPQEAQ 250

  Fly   223 QF----VENFNNLTQFERNLVSLAKSRNETEQLNFKEFLV------KHKHDRLNWTR-----FFE 272
            |.    :...:.|.||.|        ..:.:|...|.|.|      :.....::|..     |..
Mouse   251 QHASWSIVFTSRLFQFLR--------PQQQQQAQDKLFHVVTIDELQEMAPAIDWLSCLQAIFTP 307

  Fly   273 LAFNGSQESHWPVLNQLDNINDLVFFLEQTNLETLKGYIKMRELVKFY---GL---------WKT 325
            ::.|.||..   |::.||.:.::...:|:       |.:..||.::.|   ||         .|.
Mouse   308 MSLNSSQTL---VVHDLDYLRNMSQLVEE-------GLLNHRESIQSYMILGLVDTLSPALDTKF 362

  Fly   326 QTKTGGVQSECRSLSE------------------TYFNYALLPWFIGKVFDKERRADILSVAKDI 372
            |.....:..|.|.|.|                  .:|...|...|:.:.|....::..:.:..:|
Mouse   363 QEARRELIQELRKLKERPPLPAYPRWMKCVEQTGAFFEPTLAALFVREAFGPSIQSAAMELFAEI 427

  Fly   373 KDTFYDLLDHHTWLDEDTRSQAKTKLASMDILVGYTDDLQHREVIDGVYSDINMTGNWFENL--C 435
            ||.....|...:|:.|:|:.:|..|||.:.:.:|........::....|:||.:..::.::.  |
Mouse   428 KDAVIIRLKKLSWISEETQKEALNKLAQLQVEMGAPKRAVKPDIATQEYNDIQLGPSFLQSFLSC 492

  Fly   436 ILEGSRARIRLRSVDKALIPLLMPTR-------TVNAYYADFLNLAFITIGMAQWPFYHIDFPDV 493
            :     ..:|.|:|...|.|  .|..       .|||||:...::.....|:.|.||:|..:|..
Mouse   493 V-----RSLRARNVQSFLQP--FPYHRWQKSPWEVNAYYSISDHMVVFPAGLLQPPFFHPGYPRA 550

  Fly   494 LKYAGVGNIIGHEMAHGFDSYCYQYNYDGKKTNWWSSASLRNFKERYRCLESQYNKFILMGVQT- 557
            :.:...|:|:.||:.|.|    ||....|    ...:......:|...|||..|..|.|..:.:
Mouse   551 VNFGAAGSIMAHELLHIF----YQLLLPG----GCPACDTHVLQEALLCLERHYAAFPLPSISSF 607

  Fly   558 NGSLTSGDNIADNVGTRMAYYAFKRK----TGDKAWLEKPLRGVNFNNKQLFFVKFAQTWCNGKD 618
            |||.|..:|.||..|..:|:.|:.::    ||     |..|..::.:..||||..:||..|.|..
Mouse   608 NGSHTLLENAADIGGVAIAFQAYSKRIVEHTG-----ELTLPNLDLSPYQLFFRSYAQVMCRGLS 667

  Fly   619 NGDKLRRLKTDVHAYDEFRVQGTLSNMPEFSEAFNCKLGTEMNPLKKCVVW 669
            :.|     ..|.|:....||.|.|||.|:|::.|:|..||.:||..:|.:|
Mouse   668 SQD-----PQDPHSPPSLRVHGPLSNTPDFAKHFHCPRGTLLNPSARCKLW 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl7	NP_001285879.1	PepO	43..669	CDD:226118	177/713 (25%)
Nepl7	NP_001285879.1	M13	52..666	CDD:189000	173/701 (25%)
Kel	NP_115929.3	M13	78..711	CDD:341056	173/702 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841064
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6404
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.760