DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl7 and nep-20

DIOPT Version :9

Sequence 1:	NP_001285879.1	Gene:	Nepl7 / 34671	FlyBaseID:	FBgn0032442	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001317749.1	Gene:	nep-20 / 188176	WormBaseID:	WBGene00020293	Length:	834	Species:	Caenorhabditis elegans

Alignment Length:	711	Identity:	147/711 - (20%)
Similarity:	255/711 - (35%)	Gaps:	191/711 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 FLLSTMNRT-IDPCENFYEFSCGGWKKADLVPEQARNTSFLNAIQHKIDEQIQGFLQNATKRELE 106
            |.||....| :..|.|||:.:||.:|....: ::.|:.        |..|.::..::...:|...
Worm   225 FELSAYQDTSVSKCHNFYKATCGKYKHHQAL-DKHRDA--------KKKEVVKRIVREFLRRNES 280

  Fly   107 DLGVNGTTSAEIKAKQFYASCVEMKANLSLGYQYFMEHDGDRLKERNATYDWMYINFMSKYDIYP 171
            .:    |:..|...:..:..|.:.                    .:|.||..::.: :.|...:|
Worm   281 SI----TSKFEPAIRLMFGKCNKF--------------------SQNKTYLDIFKD-IEKIGPWP 320

  Fly   172 LLALKVHYSTSSRKFDILLTLPSKVLA----GFSEEQLKNMTREFGLDSSAEKVKQFVENFNNLT 232
            :|        .|...|::..|...:|:    ||:         :|||         |...|..|.
Worm   321 VL--------KSDWVDVMFNLNDYLLSLVELGFT---------DFGL---------FKLEFRQLA 359

  Fly   233 --QFERNLVSLAKSRNETEQL----------------------NFKEFLVKHKHDRLNWTRFFEL 273
              ||.....|..|..|:.|::                      .:.||..:.:|..|..|....:
Worm   360 FGQFPVIAPSEQKQGNQLEKIILEILEANGVQADRQKLSKYLREYSEFKSQLRHMSLEGTSVKYI 424

  Fly   274 AFNGSQESHWPVLNQLDNINDLV---------------------------FF-------LEQTNL 304
            .:|.|..|        .||:.||                           ||       ::||:.
Worm   425 RYNASTLS--------VNISALVQKMAPMSTSSGLVRRIQSGILITNSSSFFGKNLDAIIQQTHK 481

  Fly   305 ETLKGYIKMRELVKFYGLWKTQTKTGGVQSECRSLSETYFNYALLP----WFIGKVF-DKERRAD 364
            .||..|:    :..|.........:|...||...:.       |||    ..:.:.| |:|.:..
Worm   482 RTLANYL----IFHFIDAVTFDLTSGAKHSEHTLID-------LLPRGSLQVLSQDFVDEEDQGV 535

  Fly   365 ILSVAKDIKDTFYDLLDHHTWLDE-----DTRSQAKTKLASMDILVGYTDDLQHREVIDGVYSDI 424
            ::.:|||:|....:::...:.||:     :.:.:.|......||||.....|   |:::..:..:
Worm   536 MVEMAKDLKKHVVEMISEGSSLDKGHLVFEEKERRKLIRKVQDILVVTKYPL---EILNQNFEKL 597

  Fly   425 NMTGNWFENLCILEGSRARIRLRSVDKALIPLLMPT---RTVNAYYADFLNLAFITIGMAQWPFY 486
            |:|  :.::|..:.....|.|...:.:.|...|.||   ...:|:|....|...|...:...|::
Worm   598 NLT--YSDSLHKIIQKLRRFRSEQLIEYLGGDLDPTDKGMWGSAHYEQATNDLIIIAPIIDGPYF 660

  Fly   487 HIDFPDVLKYAGVGNIIGHEMAHGFDSYCYQYNYDGKKTNWWSSASLRNFKERYRCLESQYNKFI 551
            ...:|:.:....:|.||..|:....||...:.:..|...||..|.||:.|....:|    :.|.|
Worm   661 DTSYPNYVNIFFMGFIISRELGRSLDSVRIRKDEKGHTENWLKSESLKRFDNNVKC----WRKKI 721

  Fly   552 LMGVQTNGSLTSGDNIADNVGTRMAYYAFKRKTGDKAWLEKPLRGV---------NFNNKQLFFV 607
                  .|:....:.:||:||...::.|.|:      | ||.:.|.         :...:|:||.
Worm   722 ------TGTRFLNEMLADHVGHEASFMALKK------W-EKEMNGTIVEKIRGYESMTMEQIFFH 773

  Fly   608 KFAQTWCN--GKDNGDKLRRLKTDVHAYDEFRVQGTLSNMPEFSEAFNCKLGTEMNPLKKC 666
            ..|..:|.  |...|:...:   |...:...||.....|||:|::||.|.....||...||
Worm   774 LQALYFCRPPGGSTGELTAK---DARQHYSTRVNEAFKNMPQFAKAFGCSSNQNMNSKTKC 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl7	NP_001285879.1	PepO	43..669	CDD:226118	147/711 (21%)
Nepl7	NP_001285879.1	M13	52..666	CDD:189000	141/699 (20%)
nep-20	NP_001317749.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920