DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl7 and nep-6

DIOPT Version :9

Sequence 1:	NP_001285879.1	Gene:	Nepl7 / 34671	FlyBaseID:	FBgn0032442	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_494537.1	Gene:	nep-6 / 184628	WormBaseID:	WBGene00017550	Length:	726	Species:	Caenorhabditis elegans

Alignment Length:	699	Identity:	161/699 - (23%)
Similarity:	289/699 - (41%)	Gaps:	142/699 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 LLSTMNRTIDPCENFYEFSCGGWKKADLVPEQARNTSFLNAIQHKIDEQIQGFLQNATKRELEDL 108
            ||:..:.::|||::||:.:||.:.:.::...:.:....:      |...|:.||   .|.|..:
Worm    97 LLNFQDPSVDPCQDFYKAACGKYSEHEVANRRLQKKDII------IQRMIKNFL---LKNETSE- 151

  Fly   109 GVNGTTSAEIKAKQFYASCVEMK------ANLSLGYQYFMEHDGDRL----------KERNATYD 157
                 :.:|...:|.|.:|..:|      ||:...::...: |..::          .|.....:
Worm   152 -----SKSENVMRQVYRTCEGLKNEEIFNANMKTAFRELFK-DIQKIGSWPAADKNWDETKLNLN 210

  Fly   158 WMYINFM----SKYDIY-------PLLAL--------KVHYSTSSRKFDIL----LTLPSKVLAG 199
            .|.:|.:    |.:.::       |.|.:        ||..:.....||||    |.....|:|.
Worm   211 EMLLNIVKLGSSNFGLFQIRPTEVPFLEVAPDMARSPKVSANFQQIIFDILEKNGLQPDENVIAD 275

  Fly   200 FSEE--QLKNMTREFGLDSSAEKVKQFVENFNNLTQFERNLVSLAKSRNETEQLN---------- 252
            ..|:  .|:....::..|.:|||| ||       ::.:..:.||...:...|.:|
Worm   276 DVEDYITLEETLSQYAYDYNAEKV-QF-------SKLQAQVPSLKLEKIIEEMMNPNRKKLLVTK 332

  Fly   253 FKEFLVKHKHDRLNWTRFFELAFNGSQESHWPVLNQLDNINDLVFFLEQTNLETLKGYIKMRELV 317
            .|..:|.|||.                                :||.|:.|||.|......|.|.
Worm   333 VKPRMVAHKHS--------------------------------LFFDEKMNLEKLLKSTPKRTLA 365

  Fly   318 KFYGLWKTQTKTGGV--------QSECRSLSETYFNYALLPWFIGKVFDKERRADILSVAKDIKD 374
            .:...:.......|:        :..|..|...|...|.|..|:...|:|.....:..:|::.|.
Worm   366 NYLIFYYMDHAMNGLSVHDNVIKKRNCEKLVIEYLPKASLRVFVRNHFEKGNLKIVDEMAEETKK 430

  Fly   375 TFYDLLDHHTWLDEDTRSQAKTKLASMDILVGYTDDLQHREVIDGVYSDINM------------T 427
            :|.::|...|||..|::..|..||..|..::||..:.:.:..:|.::..:.:            .
Worm   431 SFIEMLQESTWLGADSKKNAILKLEKMGKMIGYPKEFEKKGALDKMFETLKLLPKDTLYGILKKI 495

  Fly   428 GNWFENLCILEGSRARIRLRSVDKALIPLLMPTRTVNAYYADFLNLAFITIGMAQWPFYHIDFPD 492
            |.:.     :|.....:.|.:....::|:||    .||:|.|..:|:|: :|....|.:...:|.
Worm   496 GRFH-----MEQGIEFVALETPMDPVLPVLM----TNAFYTDRNHLSFL-VGYMDDPLFDATYPK 550

  Fly   493 VLKYAGVGNIIGHEMAHGFDSYCYQYNYDGKKTNWWSSASLRNFKERYRCLESQYNKF--ILMGV 555
            .:..|..|||:.||.:||||:...:.:.:|:..:|.....|:.:.::.:||..|||::  .:.|.
Worm   551 YVNIALTGNILAHETSHGFDTAGIKRDENGEVRSWMKPEDLKEYGKKTQCLVDQYNEYDDPVFGK 615

  Fly   556 QTNGSLTSGDNIADNVGTRMAYYAFKRKTGDKAWLEKPLRGVNFNNKQLFFVKFAQTWCNGKDNG 620
            ..||:.|..:.:||.:|..:|:..|::....|.  :|.:...|.|..:|:|...|..:|:.....
Worm   616 NLNGTTTLNEMVADMIGVTVAWKVFEKLDSSKE--QKVIGFENENIDKLYFRAAALDFCSLPPTT 678

  Fly   621 DKLRRLKTDVHAYDEFRVQGTLSNMPEFSEAFNCKLGTEMNPLKKCVVW 669
            ..:..| |.||....|||.|..||||:|:.||||..|:.|||..:|.::
Worm   679 SLVEEL-TRVHPTGNFRVNGIFSNMPQFATAFNCPEGSPMNPKTRCSIF 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl7	NP_001285879.1	PepO	43..669	CDD:226118	161/697 (23%)
Nepl7	NP_001285879.1	M13	52..666	CDD:189000	158/686 (23%)
nep-6	NP_494537.1	M13	105..724	CDD:189000	158/687 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6404
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.870