DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl7 and EEF1AKMT4-ECE2

DIOPT Version :9

Sequence 1:	NP_001285879.1	Gene:	Nepl7 / 34671	FlyBaseID:	FBgn0032442	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_055508.3	Gene:	EEF1AKMT4-ECE2 / 110599583	HGNCID:	53615	Length:	883	Species:	Homo sapiens

Alignment Length:	711	Identity:	205/711 - (28%)
Similarity:	320/711 - (45%)	Gaps:	136/711 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 LLSTMNRTIDPCENFYEFSCGGWKKADLVPEQARNTSFLNAIQHKIDEQIQGFLQNATKRELEDL 108
            :|.:::|.:.|||:||:||||||.:.:.:|:.....:..|::.    :|.|..|    |..||:.
Human   224 ILESLDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLW----DQNQAIL----KHLLENT 280

  Fly   109 GVNGTTSAEIKAKQFYASCVEMKANLSLGYQYFMEHDGDRLKER----NATYDWMYINFM----- 164
            ..|.::.||.|.::||.||::::....||.|...:     |.|:    |.|..|...|||
Human   281 TFNSSSEAEQKTQRFYLSCLQVERIEELGAQPLRD-----LIEKIGGWNITGPWDQDNFMEVLKA 340

  Fly   165 --SKYDIYPLLALKVHYSTSSRKFDIL------LTLPS-----------KVLAGFSEEQLKNMTR 210
              ..|...|...:.:...:.|...:::      |.|||           |||..:.:     ...
Human   341 VAGTYRATPFFTVYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLD-----YME 400

  Fly   211 EFGL------DSSAEKVKQFVE---NFNNLT--QFER-------------NLVSLAKSRNETEQL 251
            |.|:      .|:.|:::|.:|   ...|:|  |.:|             .|.:||.|.:..|.|
Human   401 ELGMLLGGRPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPSMDWLEFL 465

  Fly   252 NF---------KEFLVKHKHDRLNWTRFFELAFNGSQESHWPVLNQLDNINDLVFFLEQTNLETL 307
            :|         .|.:|.:..|.|.  :..|| .|.::.|   :||     |.|::.|.|....:|
Human   466 SFLLSPLELSDSEPVVVYGMDYLQ--QVSEL-INRTEPS---ILN-----NYLIWNLVQKTTSSL 519

  Fly   308 KGYIKMRE---LVKFYGL-------WKTQTKTGGVQSECRSLSETYFNYALLPWFIGKVFDKERR 362
            ....:..:   |...||.       |:|          |.|.::....:||...|:...||::.:
Human   520 DRRFESAQEKLLETLYGTKKSCVPRWQT----------CISNTDDALGFALGSLFVKATFDRQSK 574

  Fly   363 ADILSVAKDIKDTFYDLLDHHTWLDEDTRSQAKTKLASMDILVGYTDDLQHREVIDGVYSDINMT 427
            .....:..:|:..|.:.|....|:||.||..||.|..::..::|:.|.:...:.:|.||....::
Human   575 EIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEIS 639

  Fly   428 -GNWFENLCILEGSRARIRLRSVDKALIPLLMPTR--------TVNAYYADFLNLAFITIGMAQW 483
             .::|:|:..|....|::....:.|.      |:|        ||||||....|......|:.|.
Human   640 EDSFFQNMLNLYNFSAKVMADQLRKP------PSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQA 698

  Fly   484 PFYHIDFPDVLKYAGVGNIIGHEMAHGFDSYCYQYNYDGKKTNWWSSASLRNFKERYRCLESQYN 548
            |||..:.|..|.:.|:|.::|||:.|.||....:|:.:|....||.:.||..|:....|:|.|||
Human   699 PFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYN 763

  Fly   549 KFILMGVQTNGSLTSGDNIADNVGTRMAYYAFKRKTGDKAWL-----EKPLRGVNFNNKQLFFVK 608
            ::.:.|.:.||..|.|:|||||.|.:.||.|:      ||||     |:.|..|...|.|||||.
Human   764 QYQVNGERLNGRQTLGENIADNGGLKAAYNAY------KAWLRKHGEEQQLPAVGLTNHQLFFVG 822

  Fly   609 FAQTWCNGKDNGDKLRRLKTDVHAYDEFRVQGTLSNMPEFSEAFNCKLGTEMNPLKKCVVW 669
            |||.||:.:........|.||.|:...|||.|||||..:|...|.|.:|:.|||.:.|.||
Human   823 FAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl7	NP_001285879.1	PepO	43..669	CDD:226118	203/709 (29%)
Nepl7	NP_001285879.1	M13	52..666	CDD:189000	200/698 (29%)
EEF1AKMT4-ECE2	NP_055508.3	Methyltransferase-like region. /evidence=ECO:0000305	1..160
		Methyltransf_25	62..>128	CDD:316196
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250\|UniProtKB:P0DPD7	88..89
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250\|UniProtKB:P0DPD7	113..114
		M13	232..881	CDD:189000	200/699 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920