DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl7 and phex

DIOPT Version :9

Sequence 1:	NP_001285879.1	Gene:	Nepl7 / 34671	FlyBaseID:	FBgn0032442	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	XP_004911718.1	Gene:	phex / 100496470	XenbaseID:	XB-GENE-1012247	Length:	750	Species:	Xenopus tropicalis

Alignment Length:	762	Identity:	187/762 - (24%)
Similarity:	324/762 - (42%)	Gaps:	148/762 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LISLTLIGRVLAN---DLFSLPPATNHREEMLEDYGRFLLSTMNRTIDPCENFYEFSCGGWKKAD 70
            |:.|.|:.:.|.:   |.:.|.|      |.:| ....:.|.||.::|||::|::::||||.:.:
Frog    36 LVLLLLVSKGLISFQKDEYCLTP------ECIE-AAASIRSKMNLSVDPCDDFFQYACGGWIEEN 93

  Fly    71 LVPEQARNTSFLNAIQHKIDEQIQGFLQNATKRELEDLGVNGTTSAEIKAKQFYASCVEMKANLS 135
            .:|:...|......::..:|.:::..|:....:..:...:.       |.|.||.||:.
Frog    94 PIPDDMSNYGIYPWLRTNVDLKLKALLEKPISKRRDSEAIQ-------KVKTFYISCMN------ 145

  Fly   136 LGYQYFMEHDGDR-----LKERNATYDWMYINFMS-------KYDIYPLLA-LKVHYSTSSRKFD 187
               :..:|.|..:     ||:.:..:..:..|..|       |:.....:| |:..||||. ...
Frog   146 ---ETQIEEDDIKPILKILKQPSLRWPVLESNIGSDGKWSERKFSFLQTVADLRRLYSTSV-FLR 206

  Fly   188 ILLTLPSKVLAGF----SEEQLKNMTREFGLDSS--AEKVKQFVENF---------NNLTQFERN 237
            :.:.:..||...|    .:..|..::.|..||:|  |:|.:..:..|         .|.|:.|.:
Frog   207 VYVAIDDKVSNNFILKLDQASLSLLSHEDYLDNSTIAKKYRDALLEFMVDVAVLLGANKTRAETD 271

  Fly   238 LVSLAK-----------SRNETEQLNFKEFLVKHKH---DRLNWTRFFE--LAFNGSQESHWPVL 286
            :.:|.:           ..|.|.::.:.:..:....   .:.:|..:.:  :.||     .:|.|
Frog   272 MKALIELETKLAQITVPQENRTSEMMYNKMNISELSAMIPQFDWLSYLKNIIDFN-----IYPEL 331

  Fly   287 NQLD-----------NINDLVFFLEQTNLETLKGYIKMRELVKFYGLWKTQTKTGGVQSECRSLS 340
            ..:|           :..||...:|.....||..|:          :|:.      |.|...:||
Frog   332 KNIDLSENVIVRVPQHFKDLFNIIESEEKRTLANYL----------IWRL------VYSRIPNLS 380

  Fly   341 ETY------------------------FNYA--LLPWFIGKVF----DKERRADILSVAKD-IKD 374
            ..:                        .||.  .:|:.:||:|    .:|.:.|::....| |:.
Frog   381 RRFQYRQLEFARILLGTNSLAGRWDRCVNYVENSIPYPVGKLFVDAHFQEDKKDMMEELVDGIRW 445

  Fly   375 TFYDLLD-HHTWLDEDTRSQAKTKLASMDILVGY-----TDDLQHREVIDGVYSDINMTGNWFEN 433
            .|.|:|: .:.|:|.:|:.:||.|..::...|||     .|...:.::....:|:.:..||..:.
Frog   446 AFIDMLEKENDWMDAETKIKAKQKAVTVMAKVGYPEFLFNDTYLNEDIKMLKFSESDYFGNVLQT 510

  Fly   434 LCILEGSRARIRLRSVDKALIPLLMPTRTVNAYYADFLNLAFITIGMAQWPFY-HIDFPDVLKYA 497
            |..:..|......|:|.|... ...|| ||||:|:...|......|..|.||: .:.:|..|.|.
Frog   511 LHFISQSDFYWLRRNVPKKEW-FTNPT-TVNAFYSASTNQIRFPAGELQKPFFWGVQYPRSLSYG 573

  Fly   498 GVGNIIGHEMAHGFDSYCYQYNYDGKKTNWWSSASLRNFKERYRCLESQYNKFI--LMGVQTNGS 560
            .:|.|:|||..||||:...:|:.:|...:||:|.|...||.:..|:..|||.:.  ..|:...|.
Frog   574 AIGVIVGHEFTHGFDNNGRKYDKEGNLFSWWTSESEERFKNKTLCMVEQYNNYYWKQAGLHVKGM 638

  Fly   561 LTSGDNIADNVGTRMAYYAFKRKTGD--KAWLEKPLRGVNFNNKQLFFVKFAQTWCNGKDNGDKL 623
            .|..:|||||.|.|.::.|:::...|  |...|..|.|::.||.||||:.:|...||........
Frog   639 KTLSENIADNGGIRESFRAYRKWIEDLRKGKEEMLLPGLDLNNNQLFFISYAHVRCNSFRIESAR 703

  Fly   624 RRLKTDVHAYDEFRVQGTLSNMPEFSEAFNCKLGTEMN-PLKKCVVW 669
            .::...||:..:|||.|.:||..||.:||:|...::|| ....|.||
Frog   704 DQIMNGVHSPPQFRVIGAMSNFEEFHKAFSCPKDSKMNRGANSCRVW 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl7	NP_001285879.1	PepO	43..669	CDD:226118	176/723 (24%)
Nepl7	NP_001285879.1	M13	52..666	CDD:189000	172/711 (24%)
phex	XP_004911718.1	M13	75..741	CDD:341056	170/705 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010