DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl7 and ece2

DIOPT Version :9

Sequence 1:	NP_001285879.1	Gene:	Nepl7 / 34671	FlyBaseID:	FBgn0032442	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	XP_002935189.1	Gene:	ece2 / 100488407	XenbaseID:	XB-GENE-1011916	Length:	766	Species:	Xenopus tropicalis

Alignment Length:	768	Identity:	219/768 - (28%)
Similarity:	341/768 - (44%)	Gaps:	163/768 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVNALWATLISLTLIGRVLANDLFSLPPATNH---REEMLEDYGRFLLSTMNRTIDPCENFYEFS 62
            ::.||.|.| .:.|:|.::|..:..:...:..   .|..:...|| :|.:::|.||||::||::|
Frog    63 LLGALSAVL-GVLLLGSLIALGVQQMTDRSRSLCLSEACVSVAGR-ILDSLDRGIDPCQDFYQYS 125

  Fly    63 CGGWKKADLVPEQARNTSFLNAIQHKIDEQIQGFLQNATKRELEDLGVNGTTSAEIKAKQFYASC 127
            ||||.:.:.:|:.....:..|:|..:....::..|:|||        .|.::.||:|.::||.||
Frog   126 CGGWMRRNPLPDGRSRWNTFNSIWDQNQAILKHILENAT--------FNSSSEAEMKTQRFYLSC 182

  Fly   128 VEMKANLSLGYQYFMEHDGDRLKER------------NATYDWMYINFMS-------KYDIYPLL 173
            ::             |...:.|:::            |.:.:|...||||       .|...|..
Frog   183 LK-------------EQRIEELRQKPLTDLIEKIGGWNISGNWRGENFMSVLKTVSGTYRATPFF 234

  Fly   174 ALKVHYSTSSRKFDIL------LTLPS-----------KVLAGFSEEQLKNMTREFG-----LDS 216
            ::.|...:.|...:|:      |.|||           |||..:. :.:.::....|     :|.
Frog   235 SVFVSADSKSSNSNIIQVDQSGLFLPSRDYYLNKTANGKVLDAYL-QYMVSVGELLGGSPGSVDM 298

  Fly   217 SAEKVKQFVENFNNLT--QFER-------------NLVSLAKSRNETEQLNF------------- 253
            ...::.:|.....|||  |.||             .|.|||.:.:..:.|.|
Frog   299 QMTQILEFETLLANLTVPQDERRDEEKIYNRMTISELQSLAPAFDWMDYLTFALSPLDLNDTEPV 363

  Fly   254 ----KEFLVKHKHDRLNWTRFFELAFNGSQESHWPVLNQLDNINDLVFFLEQTNLETLKGYIKMR 314
                ||:|          .:..||..|..     |:|  |:|.  ||:.|.|....:|....:..
Frog   364 VVYGKEYL----------QQVSELVNNTD-----PML--LNNY--LVWNLVQKMSSSLDSRFEKA 409

  Fly   315 E---LVKFYGL-------WKTQTKTGGVQSECRSLSETYFNYALLPWFIGKVFDKERRADILSVA 369
            :   |...||.       |:|          |.|.::....:||...|:...|||..:.....:.
Frog   410 QDKLLESLYGAKKSCTPRWQT----------CLSNTDDTLGFALGSLFVKSTFDKNSKNIAEQMI 464

  Fly   370 KDIKDTFYDLLDHHTWLDEDTRSQAKTKLASMDILVGYTDDLQHREVIDGVYSDINMTGN-WFEN 433
            .:|:|.|...|...||:||.||..||.|..::..::|:.|.:...:.:|.||....::.: :|:|
Frog   465 SEIRDAFELTLGGLTWMDEKTRRAAKEKADAIYDMIGFPDFILDTKELDEVYDGFEVSEDAFFQN 529

  Fly   434 LCILEGSRARIRLRSVDK-------ALIPLLMPTRTVNAYYADFLNLAFITIGMAQWPFYHIDFP 491
            :.......|::....:.|       ::.|     :||||||....|......|:.|.|||....|
Frog   530 MLNFYNFSAKLMAEQLRKPPNREQWSMTP-----QTVNAYYLPNKNEIVFPAGILQAPFYAPTHP 589

  Fly   492 DVLKYAGVGNIIGHEMAHGFDSYCYQYNYDGKKTNWWSSASLRNFKERYRCLESQYNKFILMGVQ 556
            ..|.:.|:|.::|||:.|.||....:|:.||....||.::||..||.|..|:.:|||.:.:.|.:
Frog   590 KALNFGGIGVVMGHELTHAFDDQGREYDEDGNLRPWWQNSSLEAFKNRTECMVNQYNSYTVNGER 654

  Fly   557 TNGSLTSGDNIADNVGTRMAYYAFKRKTGDKAWL-----EKPLRGVNFNNKQLFFVKFAQTWCNG 616
            .||..|.|:|||||.|.:.||:|:      |:||     ||.|.||...|.|||||.|||.||:.
Frog   655 VNGRQTLGENIADNGGLKAAYHAY------KSWLVKHGEEKQLPGVGLTNNQLFFVGFAQVWCSV 713

  Fly   617 KDNGDKLRRLKTDVHAYDEFRVQGTLSNMPEFSEAFNCKLGTEMNPLKKCVVW 669
            :........|.||.|:..:|||.|||||..:|:|.|||..||.|||.|.|.||
Frog   714 RTPESSHEGLVTDPHSPAKFRVIGTLSNSKDFAEHFNCPKGTPMNPGKHCDVW 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl7	NP_001285879.1	PepO	43..669	CDD:226118	207/721 (29%)
Nepl7	NP_001285879.1	M13	52..666	CDD:189000	204/709 (29%)
ece2	XP_002935189.1	M13	115..763	CDD:341056	204/709 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020