DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nub and Pou5f2

DIOPT Version :9

Sequence 1:	NP_001097153.1	Gene:	nub / 34669	FlyBaseID:	FBgn0085424	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_083591.1	Gene:	Pou5f2 / 75507	MGIID:	1922757	Length:	329	Species:	Mus musculus

Alignment Length:	254	Identity:	78/254 - (30%)
Similarity:	115/254 - (45%)	Gaps:	69/254 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   694 PRSSTPHSIRSPIAIRSPASSPQQLHHHHHHPLQITPPSSAASLKLSGMLTPSTPTSGTQMSQGT 758
            |..|:|:..|..||                       |..|...:           :.:|.|...
Mouse    57 PLGSSPYEFRGGIA-----------------------PYRACEAR-----------AWSQSSSED 87

  Fly   759 TTPQPKTVASAAAARAAGEPSPEETTDLE-ELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDF 822
            |.|.|..........|.    ||:.:.:: |:||.||..:|:|:.||::|.|||.|:|.::|...
Mouse    88 TCPGPYIALRYMPNLAL----PEDVSAIQKEMEQLAKELRQKRMTLGYSQADVGFAVGAMFGKVL 148

  Fly   823 SQTTISRFEALNLSFKNMCKLKPLLQKWLDDADRTIQATGGVFDPAALQATVSTPEIIG------ 881
            |||||.||||..||..||.||:|||:.||::.|.                    ..::|
Mouse   149 SQTTICRFEAQQLSLANMWKLRPLLKMWLEEVDE--------------------KNLLGICRMEM 193

  Fly   882 ----RRRKKRTSIETTIRGALEKAFLANQKPTSEEITQLADRLSMEKEVVRVWFCNRRQ 936
                .|:::|.|.|..|...|||.||...:||.::|:.:|.||.::|::|:|||.||.|
Mouse   194 ILEQARKRRRASRERRIGSNLEKLFLQCPEPTPQQISYIAGRLRLQKDLVQVWFSNRSQ 252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nub	NP_001097153.1	DUF4472	315..>399	CDD:291409
		POU	791..855	CDD:197673	34/63 (54%)
		Homeobox	886..939	CDD:278475	23/51 (45%)
Pou5f2	NP_083591.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Pou	113..181	CDD:278582	36/67 (54%)
		Homeobox	<214..250	CDD:278475	16/35 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810