DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nub and pou4f1

DIOPT Version :9

Sequence 1:	NP_001097153.1	Gene:	nub / 34669	FlyBaseID:	FBgn0085424	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_001299795.1	Gene:	pou4f1 / 58057	ZFINID:	ZDB-GENE-000523-2	Length:	366	Species:	Danio rerio

Alignment Length:	382	Identity:	118/382 - (30%)
Similarity:	170/382 - (44%)	Gaps:	77/382 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   605 FAQFHQLLQQRQVALTQQFNSYMELLRSGSLGLAQDDPALTAQVAAAQFLMQSQLQALSQASQQL 669
            ||....|.:.:...|    :|..|.:|...|    ..|.|.:.:.|:   :...|.|.::|...:
Zfish    11 FAMHPSLPEHKYTTL----HSSSEAIRRACL----QTPQLQSNIFAS---LDETLLARAEALAAV 64

  Fly   670 QALQKQQQRQVDEPLQLNHKMTQQPRSSTPHSIRSPIAIRSPASSPQQLHHHHHH----PLQITP 730
            .....|.:....:|....|.|...|.|||     |.:    |.:.....||||||    |..:..
Zfish    65 DIAVSQGKSHPFKPDATYHTMNTVPCSST-----STV----PLAHHHHHHHHHHHQNLEPADLME 120

  Fly   731 PSSAASLKL-----------------SGMLTPS----------TPTSGTQMSQGTTTPQPKTVAS 768
            ..::.||.|                 .|:::.|          |..|...|:..:.......:..
Zfish   121 HITSPSLALMPSAHEGAGGGGGGGGGGGLISTSAHPHSHMHGLTHLSHQAMNMNSPLSHHGLLPG 185

  Fly   769 AAAARAAGEPS---------PEETTDLEELEQFAKTFKQRRIKLGFTQGDVG--LAMGKLYG-ND 821
            .......|.|.         .:..||..|||.||:.|||||||||.||.|||  ||..|:.| ..
Zfish   186 HHGGAHQGAPGLVNNGLPSINDSDTDPRELEAFAERFKQRRIKLGVTQADVGGALANLKIPGVGS 250

  Fly   822 FSQTTISRFEALNLSFKNMCKLKPLLQKWLDDADRTIQATGGVFDPAALQATVSTPEII--GRRR 884
            .||:||.|||:|.||..||..|||:||.||::|:            .|.:..:|.|:|.  ..::
Zfish   251 LSQSTICRFESLTLSHNNMIALKPILQAWLEEAE------------GAQREKMSKPDIFNGSEKK 303

  Fly   885 KKRTSIETTIRGALEKAFLANQKPTSEEITQLADRLSMEKEVVRVWFCNRRQKEKRI 941
            :|||||....:.:||..|....:|:||:|..:|::|.::|.||||||||:|||:||:
Zfish   304 RKRTSIAAPEKRSLEAYFAVQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRL 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nub	NP_001097153.1	DUF4472	315..>399	CDD:291409
		POU	791..855	CDD:197673	39/66 (59%)
		Homeobox	886..939	CDD:278475	26/52 (50%)
pou4f1	NP_001299795.1	POU	207..284	CDD:197673	44/76 (58%)
pou4f1	NP_001299795.1	Homeobox	305..358	CDD:278475	26/52 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810