DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nub and pou4f4

DIOPT Version :9

Sequence 1:	NP_001097153.1	Gene:	nub / 34669	FlyBaseID:	FBgn0085424	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_001073527.1	Gene:	pou4f4 / 572084	ZFINID:	ZDB-GENE-061215-70	Length:	343	Species:	Danio rerio

Alignment Length:	375	Identity:	125/375 - (33%)
Similarity:	180/375 - (48%)	Gaps:	77/375 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   601 SPQDFAQFHQLLQQRQVALTQQFNSYMELLRSGSLGLAQDDPALTAQVAAAQFLMQSQLQALSQA 665
            |.|.|: .|.:|.:.:..   ..:|..|.:|...|    ..|:|...:.|...      :.|.|.
Zfish     6 SKQPFS-MHPILHEPKYT---PLHSSSEAIRRACL----PTPSLQGNIFAGFD------ETLLQR 56

  Fly   666 SQQLQALQKQQQRQVDEPLQLNHKMTQQPRSSTPHSIRSPIAIR-SPASSPQQLHH------HHH 723
            ::.|.|        ||...|.:|..  :| .:|.|::.:..::. :|.||...|||      |||
Zfish    57 AEALAA--------VDIVAQKSHPF--KP-DATYHTMTTMTSMTCTPTSSSGHLHHPSVLTSHHH 110

  Fly   724 HP------------LQITPPSSAASLKLSGML-TPSTPTSGTQMS---------QGTTTPQPKTV 766
            ||            |...|..|...:..|.:. |.|.|.|  .||         ..:....|..:
Zfish   111 HPHHQPTQGLEGDLLDHLPGISIGGMPGSDVCSTASHPHS--HMSAINHMQHHHPQSMNMHPHGL 173

  Fly   767 ASAAAARAAGEPSPEETTDLEELEQFAKTFKQRRIKLGFTQGDVGLAMG--KLYG-NDFSQTTIS 828
            .|.|:....|:..|    |..|||.||:.|||||||||.||.|||.|:.  |:.| ...||:||.
Zfish   174 GSHASLGGVGDSEP----DPRELESFAERFKQRRIKLGVTQADVGSALANLKIPGVGCLSQSTIC 234

  Fly   829 RFEALNLSFKNMCKLKPLLQKWLDDADRTIQATGGVFDPAALQATVSTPEII--GRRRKKRTSIE 891
            |||:|.||..||..|||:|:.||::|:|            |.:..::.|||.  |.:::|||||.
Zfish   235 RFESLTLSHNNMVALKPILEAWLEEAER------------AQREKMAKPEIFNGGDKKRKRTSIA 287

  Fly   892 TTIRGALEKAFLANQKPTSEEITQLADRLSMEKEVVRVWFCNRRQKEKRI 941
            ...:.:||..|....:|:||:|..:|::|.::|.||||||||:|||:||:
Zfish   288 APEKRSLEAYFAVQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRM 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nub	NP_001097153.1	DUF4472	315..>399	CDD:291409
		POU	791..855	CDD:197673	37/66 (56%)
		Homeobox	886..939	CDD:278475	26/52 (50%)
pou4f4	NP_001073527.1	POU	184..261	CDD:197673	42/80 (53%)
pou4f4	NP_001073527.1	Homeobox	282..335	CDD:278475	26/52 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810