DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nub and pou2f3

DIOPT Version :9

Sequence 1:	NP_001097153.1	Gene:	nub / 34669	FlyBaseID:	FBgn0085424	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	XP_005172050.1	Gene:	pou2f3 / 553427	ZFINID:	ZDB-GENE-060512-299	Length:	399	Species:	Danio rerio

Alignment Length:	344	Identity:	149/344 - (43%)
Similarity:	186/344 - (54%)	Gaps:	69/344 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   663 SQASQQLQALQKQ---QQRQVDEPLQL-NHKMTQQPRSSTPHSI-----RSPIA----------- 707
            :.|.:|.::..:|   :|..:|...|: ...:...|.|.:.|..     .||:.
Zfish     3 TDAVEQTESQHEQADIEQNGIDFTRQIKTENLNDSPHSGSSHKTCHLTQGSPLPPGQLTGEMPSL 67

  Fly   708 -------------IRSPASSPQQLHHHHHHPLQITPPS--SAASLKLSGMLTPSTP-------TS 750
                         :.||:|.........|..|.:.||:  |..|...:|:| |..|       ..
Zfish    68 HPLPQLVLMPGSHLSSPSSFLLSQAQSGHQGLSLLPPNLLSLPSQTQTGLL-PHQPGLALTPQAM 131

  Fly   751 GTQMSQGTTTPQPKTVASAAAARAAGEPSPEETTDLEELEQFAKTFKQRRIKLGFTQGDVGLAMG 815
            |.....|::......::.....:..|.|. :|..||||||||||.||||||||||||||||||||
Zfish   132 GRSGLAGSSMDGHLDMSHLQVPKHVGSPQ-DEPNDLEELEQFAKAFKQRRIKLGFTQGDVGLAMG 195

  Fly   816 KLYGNDFSQTTISRFEALNLSFKNMCKLKPLLQKWLDDADRTIQATGGVFDPAALQATVSTPEII 880
            ||||||||||||||||||||||||||||||||:|||.||:.:...|        :..|.:.|.::
Zfish   196 KLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLSDAENSPSDT--------MTNTTTLPPLM 252

  Fly   881 ---GRRRKKRTSIETTIRGALEKAFLANQKPTSEEITQLADRLSMEKEVVRVWFCNRRQKEKRI- 941
               ||:|||||||||.|:..|||.||.|.||.|||||.::::|:||||||||||||||||||||
Zfish   253 EGYGRKRKKRTSIETNIKLTLEKRFLDNPKPNSEEITLISEQLAMEKEVVRVWFCNRRQKEKRIY 317

  Fly   942 -------------NPSLDS 947
                         ||.|.|
Zfish   318 CPVSTSPIKPHNFNPRLPS 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nub	NP_001097153.1	DUF4472	315..>399	CDD:291409
		POU	791..855	CDD:197673	60/63 (95%)
		Homeobox	886..939	CDD:278475	38/52 (73%)
pou2f3	XP_005172050.1	POU	161..235	CDD:197673	67/73 (92%)
pou2f3	XP_005172050.1	Homeobox	261..314	CDD:278475	38/52 (73%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003004
OrthoInspector	1	1.000	-	-		mtm6509
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11636
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.910