DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nub and pou3f1

DIOPT Version :9

Sequence 1:	NP_001097153.1	Gene:	nub / 34669	FlyBaseID:	FBgn0085424	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_001016504.1	Gene:	pou3f1 / 549258	XenbaseID:	XB-GENE-853354	Length:	375	Species:	Xenopus tropicalis

Alignment Length:	359	Identity:	145/359 - (40%)
Similarity:	180/359 - (50%)	Gaps:	77/359 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   649 AAAQF-----------LMQSQLQALSQAS--QQLQALQKQQQRQ-----VDEPLQL-NHKMTQQP 694
            |.||:           ||......:.|.:  :::|.:..|:..|     ...|:.| :|:....|
Frog     3 ATAQYLPRNNSLPSNPLMHPDSDRMHQGTTYREVQKMMHQEYLQGLATNAGHPMSLTHHQWLPNP 67

  Fly   695 RS----------STPHSIRSPIAIRSPASSPQQLHHHHHHPLQITPPSSAASLKLSG-MLTPSTP 748
            .|          ...|......:.|...||  ..|||..|.:....|||.|..:..| .|.|.:|
Frog    68 ASDWGSGSHLGAQAEHGKSGVQSSREDLSS--SFHHHRSHLVHQQTPSSHAWAQSGGHHLPPMSP 130

  Fly   749 TSGTQM----SQGTTT-------PQPKTVASAAAARAAGEP--------------------SPEE 782
            .|.:..    ||.:.|       ||..::..:.......:|                    |.|:
Frog   131 GSNSHQPLIYSQSSYTNLNGMLGPQASSLHHSMRDPLHDDPGVLDTHVESPPQHLSHHQDHSDED 195

  Fly   783 TTDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLL 847
            ....::||||||.||||||||||||.|||||:|.||||.||||||.|||||.|||||||||||||
Frog   196 APSSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLL 260

  Fly   848 QKWLDDADRTIQATGGV--FDPAALQATVSTPEIIGRRRKKRTSIETTIRGALEKAFLANQKPTS 910
            .|||::.|.|   ||..  .|..|.|         ||:||||||||..::||||..||...||::
Frog   261 NKWLEETDST---TGSPTNLDKIAAQ---------GRKRKKRTSIEVGVKGALENHFLKCPKPSA 313

  Fly   911 EEITQLADRLSMEKEVVRVWFCNRRQKEKRINPS 944
            .|||.|||.|.:||||||||||||||||||:.|:
Frog   314 HEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPA 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nub	NP_001097153.1	DUF4472	315..>399	CDD:291409
		POU	791..855	CDD:197673	53/63 (84%)
		Homeobox	886..939	CDD:278475	36/52 (69%)
pou3f1	NP_001016504.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29		5/25 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	56..139		21/84 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..200		5/48 (10%)
		POU	194..268	CDD:197673	56/73 (77%)
		Homeobox	289..343	CDD:365835	37/53 (70%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910