DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nub and POU5F1B

DIOPT Version :9

Sequence 1:	NP_001097153.1	Gene:	nub / 34669	FlyBaseID:	FBgn0085424	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_001153014.1	Gene:	POU5F1B / 5462	HGNCID:	9223	Length:	359	Species:	Homo sapiens

Alignment Length:	220	Identity:	103/220 - (46%)
Similarity:	132/220 - (60%)	Gaps:	21/220 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   731 PSSAASLKLSGMLTPSTPTS----GTQMSQGTTTPQPKTVASAAA--ARAAGEPSPEETTDL--- 786
            |.....|...|.|..|.|.|    |.:.:....:|:|.||...|.  .:...|.:||::.|:
Human    78 PQVGVGLVPQGGLETSQPESEAGVGVESNSNGASPEPCTVPPGAVKLEKEKLEQNPEKSQDIKAL 142

  Fly   787 -EELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLQKW 850
             :|||||||..||:||.||:||.||||.:|.|:|..|||.||.|||||.|||||||||:||||||
Human   143 QKELEQFAKLLKQKRITLGYTQADVGLILGVLFGKVFSQKTICRFEALQLSFKNMCKLRPLLQKW 207

  Fly   851 LDDADRTIQATGGVFDPAALQATVSTPEIIGRRRKKRTSIETTIRGALEKAFLANQKPTSEEITQ 915
            :::||..          ..||.......::..|::||||||..:||.||..||...|||. :|:.
Human   208 VEEADNN----------ENLQEICKAETLMQARKRKRTSIENRVRGNLENLFLQCPKPTL-QISH 261

  Fly   916 LADRLSMEKEVVRVWFCNRRQKEKR 940
            :|.:|.:||:||||||||||||.||
Human   262 IAQQLGLEKDVVRVWFCNRRQKGKR 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nub	NP_001097153.1	DUF4472	315..>399	CDD:291409
		POU	791..855	CDD:197673	44/63 (70%)
		Homeobox	886..939	CDD:278475	32/52 (62%)
POU5F1B	NP_001153014.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	87..116		8/28 (29%)
		POU	138..212	CDD:197673	48/73 (66%)
		Homeobox	233..285	CDD:278475	32/52 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..322		103/220 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910