DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nub and POU3F2

DIOPT Version :9

Sequence 1:	NP_001097153.1	Gene:	nub / 34669	FlyBaseID:	FBgn0085424	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_005595.2	Gene:	POU3F2 / 5454	HGNCID:	9215	Length:	443	Species:	Homo sapiens

Alignment Length:	350	Identity:	147/350 - (42%)
Similarity:	175/350 - (50%)	Gaps:	100/350 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   655 MQSQLQALSQASQQLQALQKQQQRQVDEPLQLNHKMTQQPRSSTPHSIRSPIAIRSPASS----- 714
            :|.|.|...|..||.|..|:|||:|...|..::|.....|         .|.|.||.|::
Human   124 LQQQHQQQQQQQQQQQQQQQQQQQQQRPPHLVHHAANHHP---------GPGAWRSAAAAAHLPP 179

  Fly   715 ---------------------------PQQLHHH------------------HHHPLQITPPSSA 734
                                       |..||||                  |.||.| .||
Human   180 SMGASNGGLLYSQPSFTVNGMLGAGGQPAGLHHHGLRDAHDEPHHADHHPHPHSHPHQ-QPP--- 240

  Fly   735 ASLKLSGMLTPSTPTSGTQMSQGTTTPQPKTVASAAAARAAGEP-SPEETTDLEELEQFAKTFKQ 798
                      |..|..|.....|                |..:| |.|:|...::||||||.|||
Human   241 ----------PPPPPQGPPGHPG----------------AHHDPHSDEDTPTSDDLEQFAKQFKQ 279

  Fly   799 RRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLQKWLDDADRTIQATGG 863
            |||||||||.|||||:|.||||.||||||.|||||.|||||||||||||.|||::||.:..:...
Human   280 RRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSSGSPTS 344

  Fly   864 VFDPAALQATVSTPEIIGRRRKKRTSIETTIRGALEKAFLANQKPTSEEITQLADRLSMEKEVVR 928
            : |..|.|         ||:||||||||.:::||||..||...||:::|||.|||.|.:||||||
Human   345 I-DKIAAQ---------GRKRKKRTSIEVSVKGALESHFLKCPKPSAQEITSLADSLQLEKEVVR 399

  Fly   929 VWFCNRRQKEKRINPSLDSPTGADD 953
            ||||||||||||:.|...:..||:|
Human   400 VWFCNRRQKEKRMTPPGGTLPGAED 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nub	NP_001097153.1	DUF4472	315..>399	CDD:291409
		POU	791..855	CDD:197673	53/63 (84%)
		Homeobox	886..939	CDD:278475	36/52 (69%)
POU3F2	NP_005595.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	64..171		18/55 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..267		20/95 (21%)
		POU	262..336	CDD:197673	57/73 (78%)
		Homeobox	357..411	CDD:395001	37/53 (70%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	409..443		6/15 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810