Protein Alignment nub and POU2F2

DIOPT Version :9

• Sequence 1: NP_001097153.1
• Gene: nub / 34669
• FlyBaseID: FBgn0085424
• Length: 961
• Species: Drosophila melanogaster
• Sequence 2: XP_016882373.1
• Gene: POU2F2 / 5452
• HGNCID: 9213
• Length: 723
• Species: Homo sapiens
• Alignment Length: 586
• Identity: 216/586 - (36%)
• Similarity: 273/586 - (46%)
• Gaps: 141/586 - (24%)

  Fly   426 NSSVGTSSDRCRSPLSPALSLSHQQAKRQLMSLQPHPAHHHHNPHHLNHLNHHQYKQEEDYDDAN 490
            :||:|....|...||         :|::|.:.   .|:.|.....:....||
Human     3 HSSMGAPEIRMSKPL---------EAEKQGLD---SPSEHTDTERNGPDTNH------------- 42

  Fly   491 GGALNLTSDNSRHSTQSPSNSVKSATASPVPVISVPSPVPPMIS----------PVLAPSGCGST 545
                           |:|.|.....:.||    :.||....::|          |.|:|....:.
Human    43 ---------------QNPQNKTSPFSVSP----TGPSTKVGILSGLHLTFWGPGPCLSPPQIKAE 88

  Fly   546 TPNSMAAAAAAAAAVASTMGSGISPLLALPGMSSPQAQLAAAGLGMNNPLLTGS-------LSPQ 603
            .|:..:|.||.           :.|..|.|.:  |||||          :||||       |.|
Human    89 DPSGDSAPAAP-----------LPPQPAQPHL--PQAQL----------MLTGSQLAGLTALMP- 129

  Fly   604 DFAQFHQLLQQRQVALTQQFNSYMELLRSGSLGLAQDDPALTAQVAAAQFLMQSQLQALSQASQQ 668
              ||...||||.|..|      ....::..|...|.:..|..|..:|:.....|...:.|.::.|
Human   130 --AQQQLLLQQAQAQL------LAAAVQQSSAAAAANAAAAAAAASASSSTSSSSSSSASSSTSQ 186

  Fly   669 LQALQKQQQRQVDEPLQLNHKMTQQPRSSTPHSIRSPIAIRSPASSPQQL----------HHHHH 723
            ..|..........:|       ..||..:...::..||.:  .|...|||          .||..
Human   187 PPASSGGGDLPPPQP-------ASQPPGTPQLTLSQPIQL--TAQDIQQLLQLQQLVLVPGHHLQ 242

  Fly   724 HPLQITPPSSAAS--------------LKLSGMLTPSTPTSG--TQMSQGTTTPQPKTVASAAAA 772
            .|.|...|.:..|              .:..|.|..|.|.:|  ||.....|.|.|. ::.....
Human   243 PPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTSQPRAGLPTQAVTRPTLPDPH-LSHPQPP 306

  Fly   773 RAAGEPS-PEETTDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLS 836
            :....|| |||.:|||||||||:||||||||||||||||||||||||||||||||||||||||||
Human   307 KCLEPPSHPEEPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLS 371

  Fly   837 FKNMCKLKPLLQKWLDDADRTIQATGGVFDPAALQATVSTPE-----IIGRRRKKRTSIETTIRG 896
            |||||||||||:|||:||: |:.....:..|..|    |:|.     :.||||||||||||.:|.
Human   372 FKNMCKLKPLLEKWLNDAE-TMSVDSSLPSPNQL----SSPSLGFDGLPGRRRKKRTSIETNVRF 431

  Fly   897 ALEKAFLANQKPTSEEITQLADRLSMEKEVVRVWFCNRRQKEKRINPSLDSP-TGADDDESSYMM 960
            ||||:||||||||||||..:|::|.|||||:||||||||||||||||...:| ..:....:||..
Human   432 ALEKSFLANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKRINPCSAAPMLPSPGKPASYSP 496

  Fly   961 H 961
            |
Human   497 H 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nub	NP_001097153.1	DUF4472	315..>399	CDD:291409
		POU	791..855	CDD:197673	60/63 (95%)
		Homeobox	886..939	CDD:278475	41/52 (79%)
POU2F2	XP_016882373.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	142	1.000	Domainoid score	I4687
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	277	1.000	Inparanoid score	I2945
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003004
OrthoInspector	1	1.000	-	-		mtm8655
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11636
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9475
SonicParanoid	1	1.000	-	-		X2466
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.990