DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nub and POU2F1

DIOPT Version :9

Sequence 1:	NP_001097153.1	Gene:	nub / 34669	FlyBaseID:	FBgn0085424	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	XP_011507955.1	Gene:	POU2F1 / 5451	HGNCID:	9212	Length:	769	Species:	Homo sapiens

Alignment Length:	492	Identity:	214/492 - (43%)
Similarity:	272/492 - (55%)	Gaps:	67/492 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   488 DANGGALNLTSDNSRHSTQSPSNSVKSATASPVPVISVPSPVPPMISPVLAPSGCGSTTPNSMAA 552
            |.....:|..|:.|:.|.:|...:..:.| :.:.....|.||...||...|.:..|......:|.
Human    21 DWKNSRMNNPSETSKPSMESGDGNTGTQT-NGLDFQKQPVPVGGAISTAQAQAFLGHLHQVQLAG 84

  Fly   553 AAAAAAAVA------STMGSGISPLLALPGM------SSPQAQLAAAGLGMNNPLLTG-SLSPQD 604
            .:..|||.:      |...||.|...:.|..      :.||.||..|| |.    :|| :|:|
Human    85 TSLQAAAQSLNVQSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAG-GQ----ITGLTLTP-- 142

  Fly   605 FAQFHQLLQQRQ------VALTQQFNSYMELLRSGSLGLAQDDPALTAQVAAAQFLMQSQLQALS 663
             ||...||||.|      .|..||.::..:...:|:          |...:||..:.|..|....
Human   143 -AQQQLLLQQAQAQAQLLAAAVQQHSASQQHSAAGA----------TISASAATPMTQIPLSQPI 196

  Fly   664 QASQQLQALQKQQQRQVD-EPLQLNHKMTQ-QPR----SSTPHSIRSPIAIRSPASS-PQQLHHH 721
            |.:|.||.||:.||:.:: :...|.|..|. ||.    |.||...:..:..::..:. |||   .
Human   197 QIAQDLQQLQQLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQQ---S 258

  Fly   722 HHHPLQITPPSSAASLKLSGMLTPSTPTSGTQMSQGTTTPQPKTVASAAAARAAGEPSPEETTDL 786
            ..:.||..|     |:.|:..  |:|||.....:...|.||     |.:..:....||.||.:||
Human   259 QANLLQSQP-----SITLTSQ--PATPTRTIAATPIQTLPQ-----SQSTPKRIDTPSLEEPSDL 311

  Fly   787 EELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLQKWL 851
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||
Human   312 EELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWL 376

  Fly   852 DDADRTIQATGGVFDPAALQATVSTPEIIG--RRRKKRTSIETTIRGALEKAFLANQKPTSEEIT 914
            :||: .:.:...:..|:||    ::|.|.|  |||||||||||.||.||||:||.||||||||||
Human   377 NDAE-NLSSDSSLSSPSAL----NSPGIEGLSRRRKKRTSIETNIRVALEKSFLENQKPTSEEIT 436

  Fly   915 QLADRLSMEKEVVRVWFCNRRQKEKRINPSLDSPTGA 951
            .:||:|:|||||:||||||||||||||||.....|.:
Human   437 MIADQLNMEKEVIRVWFCNRRQKEKRINPPSSGGTSS 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nub	NP_001097153.1	DUF4472	315..>399	CDD:291409
		POU	791..855	CDD:197673	61/63 (97%)
		Homeobox	886..939	CDD:278475	43/52 (83%)
POU2F1	XP_011507955.1	POU	306..380	CDD:197673	69/73 (95%)
POU2F1	XP_011507955.1	Homeobox	408..461	CDD:278475	43/52 (83%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	142	1.000	Domainoid score	I4687
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	277	1.000	Inparanoid score	I2945
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8655
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11636
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9475
SonicParanoid	1	1.000	-	-		X2466
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.990