DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nub and POU1F1

DIOPT Version :9

Sequence 1:	NP_001097153.1	Gene:	nub / 34669	FlyBaseID:	FBgn0085424	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_001116229.1	Gene:	POU1F1 / 5449	HGNCID:	9210	Length:	317	Species:	Homo sapiens

Alignment Length:	304	Identity:	110/304 - (36%)
Similarity:	162/304 - (53%)	Gaps:	64/304 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   683 PLQLNHKMTQ-QPRSSTPHSIRSPI-AIRSPASSPQQLHHHHHHPLQITPPSSAASLKLSGMLTP 745
            ||.::|...: .|.|:...::.|.: :|.|...:|:.|..|    ..:|...:.|:     .|..
Human    24 PLIMHHSAAECLPVSNHATNVMSTVPSILSLIQTPKCLCTH----FSVTTLGNTAT-----GLHY 79

  Fly   746 STPTS--GTQMS-----QGTTTP------------------QPKTVASAAAA----------RAA 775
            |.|:.  |.|.|     .|:.||                  ||.......||          :..
Human    80 SVPSCHYGNQPSTYGVMAGSLTPCLYKFPDHTLSHGFPPIHQPLLAEDPTAADFKQELRRKSKLV 144

  Fly   776 GEPSPEETTDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNM 840
            .||...::.::.|||:||..||.||||||:||.:||.|:..::|::||||||.|||.|.|||||.
Human   145 EEPIDMDSPEIRELEKFANEFKVRRIKLGYTQTNVGEALAAVHGSEFSQTTICRFENLQLSFKNA 209

  Fly   841 CKLKPLLQKWLDDADRTIQATGGVFDPAALQATVSTPEIIG---RRRKKRTSIETTIRGALEKAF 902
            ||||.:|.|||::|::    .|.:::           |.:|   |:||:||:|....:.|||:.|
Human   210 CKLKAILSKWLEEAEQ----VGALYN-----------EKVGANERKRKRRTTISIAAKDALERHF 259

  Fly   903 LANQKPTSEEITQLADRLSMEKEVVRVWFCNRRQKEKRINPSLD 946
            ....||:|:||.::|:.|::||||||||||||||:|||:..||:
Human   260 GEQNKPSSQEIMRMAEELNLEKEVVRVWFCNRRQREKRVKTSLN 303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nub	NP_001097153.1	DUF4472	315..>399	CDD:291409
		POU	791..855	CDD:197673	39/63 (62%)
		Homeobox	886..939	CDD:278475	28/52 (54%)
POU1F1	NP_001116229.1	POU	150..224	CDD:197673	42/73 (58%)
POU1F1	NP_001116229.1	Homeobox	243..297	CDD:395001	29/53 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810