DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nub and pdm2

DIOPT Version :9

Sequence 1:	NP_001097153.1	Gene:	nub / 34669	FlyBaseID:	FBgn0085424	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_001285877.1	Gene:	pdm2 / 34673	FlyBaseID:	FBgn0004394	Length:	893	Species:	Drosophila melanogaster

Alignment Length:	949	Identity:	328/949 - (34%)
Similarity:	430/949 - (45%)	Gaps:	254/949 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 NDALPEETMATATATPTPATTASGAATAAAVATSPAAATTLKAPTATQAAATMDDIDDDDDDSNN 216
            |::..:....|||.|...|.||..||||||.||:....|:..|.|...||||          |..
  Fly    11 NNSHHQHLSTTATETAAAAATAKAAATAAAAATATMLLTSPTAATHCLAAAT----------SAA 65

  Fly   217 GGHMQNAGVGNFKFEPGQQLGTPANEA-----------------VLTSSEENKDGTLTAVDTNMR 264
            |.::|..|.|........||..|||.|                 |..:||...:|.|......::
  Fly    66 GVNVQITGQGVSATLNDDQLQLPANYAANVGHLNGFNPKDNCPPVPPTSERAFEGLLRLPQIQVK 130

  Fly   265 DVSANHSSSFLSSSPASSTLVSC----HSPSPPLPLLADQDDGTRRMRDKKLTLELKLQSCD--- 322
                   ..|:.|.|...   ||    |..:|....||..      .|.|.:.....|:..|
  Fly   131 -------QEFMESPPERP---SCHPMNHQQAPANSALATS------CRGKTILNPWYLRPADGIG 179

  Fly   323 --EYVEQPKDKGA-------------------------------ERLQPAQIANDNAPS---PLH 351
              .|.....:.|:                               |.|...:....:.|.   |||
  Fly   180 YHNYNSNNNNSGSGEINKDVSQQMTSACGGSDGQTCLPVSYFGMETLASVKQRQKSLPDFLIPLH 244

  Fly   352 -LKLEEQDEQEQADVKDKVLELTGAAV-----------------ALYGHLNNASKDVRDLEQCLK 398
             :..::|...:|..:...:..|....|                 ||..|.||.:..:.
  Fly   245 EIMFQQQHHYQQRTMGTLINSLPPGLVGYPPQKTETFKSLTPPKALQHHQNNQNHQIP------- 302

  Fly   399 LQDPNDISRLSRSPSPLQSNASDCDDNNSSVGTSSDRCRSPLSPALSLSHQQAK--RQLMSLQPH 461
                             |::..|    :|.|....:|.|  |.....|.|||.:  .:::..|..
  Fly   303 -----------------QNHTGD----HSFVRHFHERDR--LIREHQLKHQQLRDVEEVLQEQEQ 344

  Fly   462 PAHHHHN--------PHHLNHLNHHQYKQEEDYDDANGGALNL--------------TSDNSRHS 504
            .....|.        |..|.| |||.:..   ..||||.|..|              |.......
  Fly   345 DEEQEHETLRKPHVVPSELEH-NHHWHGV---VCDANGHATRLLHIAPPRAGPTPLPTHQQPPVG 405

  Fly   505 TQSPSNSVKSATASPVP----VISVP-------------------SPVPPMISPVLAPSGCGST- 545
            ...|.||...:|....|    :...|                   ||.||  ||:.:.|.||.:
  Fly   406 EVLPPNSTSFSTIVDPPKEPSIYEQPAPNGRHCRPANKVMRHMSNSPTPP--SPLRSLSDCGKSF 468

  Fly   546 ------------TPNSMAAAAAAAAAVASTMGSGISPLLALP-GMSSPQAQLAAAGLGMNNPLLT 597
                        .|.:: ::...|..:.|.:.:.:..|...| .::..|.:...|.:   ||...
  Fly   469 EEEELELGENCEMPQNL-SSKRQARELDSELENEVLDLAPPPKRLAEEQEEEKVASV---NPPQP 529

  Fly   598 GSLSPQDFAQFHQLLQQRQVALTQQFNSYMELLRSGSLGLAQD---DPALTAQVAAAQFLMQSQL 659
            .:.:|:   :.||.||       .|.:||:|::|.    ||.:   :|.|     |.|||:|:.|
  Fly   530 VAFAPE---EMHQALQ-------LQLHSYIEMVRQ----LAPEAFPNPNL-----ATQFLLQNSL 575

  Fly   660 QALSQASQQLQALQKQQQRQVDEPLQLNHKMTQQPRSSTPHSIRSPIAIRSPASSPQQLHHHHHH 724
            |||:    |.||||:.:|:|.::||         |..|||.: :||  :|||:.||..   .|..
  Fly   576 QALA----QFQALQQMKQQQREDPL---------PSYSTPLA-KSP--LRSPSLSPVP---RHSK 621

  Fly   725 PLQITPPSSAASLKL---SGMLTPSTPTSGTQMSQGTTTPQPKTVASAAAARAAGEPSPEETTDL 786
            ..|.|||:|..:..|   |.::||:||:...|.....:||:|.:..:.|:|.|..|.||||||||
  Fly   622 SQQRTPPNSMTANSLGMSSAVMTPNTPSMQQQPQLQQSTPKPTSGLTVASAMAKLEQSPEETTDL 686

  Fly   787 EELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLQKWL 851
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Fly   687 EELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLQKWL 751

  Fly   852 DDADRTI-QATGGVFDPAALQATV-STPE-IIGRRRKKRTSIETTIRGALEKAFLANQKPTSEEI 913
            :|||.|: ::.||||:...:.:|: |||| |:|||||||||||||:|..||||||.|.|||||||
  Fly   752 EDADSTVAKSGGGVFNINTMTSTLSSTPESILGRRRKKRTSIETTVRTTLEKAFLMNCKPTSEEI 816

  Fly   914 TQLADRLSMEKEVVRVWFCNRRQKEKRINPS--LDSPTG 950
            :||::||:|:|||:|||||||||||||||||  ||||||
  Fly   817 SQLSERLNMDKEVIRVWFCNRRQKEKRINPSLDLDSPTG 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nub	NP_001097153.1	DUF4472	315..>399	CDD:291409	19/140 (14%)
		POU	791..855	CDD:197673	62/63 (98%)
		Homeobox	886..939	CDD:278475	41/52 (79%)
pdm2	NP_001285877.1	POU	691..755	CDD:197673	62/63 (98%)
pdm2	NP_001285877.1	Homeobox	789..842	CDD:278475	41/52 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469480
Domainoid	1	1.000	141	1.000	Domainoid score	I4662
eggNOG	1	0.900	-	-		E1_KOG3802
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003004
OrthoInspector	1	1.000	-	-		mtm6509
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11636
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.840