DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nub and pou2f1b

DIOPT Version :9

Sequence 1:	NP_001097153.1	Gene:	nub / 34669	FlyBaseID:	FBgn0085424	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	XP_005167869.1	Gene:	pou2f1b / 323702	ZFINID:	ZDB-GENE-030131-2422	Length:	702	Species:	Danio rerio

Alignment Length:	491	Identity:	198/491 - (40%)
Similarity:	244/491 - (49%)	Gaps:	134/491 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   488 DANGGALNLTSDNSRHSTQSPSNSVKSATASPVPVISVPSPVPPMI------SPVLAPSGCGSTT 546
            |.|.||.....|..|.:.|:.| ::.:|.|..:......:|....:      :.:||
Zfish    34 DENTGAQTNGLDFQRQTVQTTS-AITNAHAQALLQQLTLTPAQQQLLLQQAQAQLLA-------- 89

  Fly   547 PNSMAAAAAAAAAVASTMGSGISPLLALPGMSSPQAQLAAAGLGMNNPLLTGSLSPQDFAQFHQL 611
                ||...:|...:||.|:.||...|.|....|.:|          |:   .::|       ||
Zfish    90 ----AAVQHSAGQQSSTTGASISASAATPITQIPLSQ----------PI---QITP-------QL 130

  Fly   612 LQQRQVALTQQFNSYMELLRSGSLGLAQDDPALTAQVAAAQFLMQSQLQALSQASQQLQALQKQQ 676
            |||:|    ||.|     |......|.|....:..|:..|||:       :||..|..|:|
Zfish   131 LQQQQ----QQQN-----LNLQQFVLVQPGHPIATQLQPAQFI-------ISQTPQGQQSL---- 175

  Fly   677 QRQVDEPLQLNHKMTQQPRSSTPHSIRSPIAIRSPASSPQQLHHHHHHPLQITPPSSAASLKLSG 741
                   ||..:.:||.|:|..                         :.||..|..:.|:
Zfish   176 -------LQAQNLLTQLPQSQA-------------------------NLLQTQPSITLAT----- 203

  Fly   742 MLTPSTPTSGTQMSQGTTTPQPKTVASAAAARAAGEPSPEETTDLEELEQFAKTFKQRRIKLGFT 806
              .|:|||...     ..||......:....:....||.||.:||||||||||||||||||||||
Zfish   204 --QPATPTRTI-----AATPIQSLAHTQTTPKHMDTPSLEEPSDLEELEQFAKTFKQRRIKLGFT 261

  Fly   807 QGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLQKWLDDADRTIQATGGVFDPAALQ 871
            |||||||||||||||||||||||||||||||||||||||||:|||:||   :.|.....|.|
Zfish   262 QGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDA---VCAENQTSDQA--- 320

  Fly   872 ATVSTPEIIG----------RRRKKRTSIETTIRGALEKAFL-ANQKPTSEEITQLADRLSMEKE 925
              :|:|..:|          |||||||||||.||.||||:|| .||||||||||.:||:|:||||
Zfish   321 --LSSPSSLGSPGLGMEGLNRRRKKRTSIETNIRVALEKSFLEQNQKPTSEEITMIADQLNMEKE 383

  Fly   926 VVRVWFCNRRQKEKRINP------------SLDSPT 949
            |:||||||||||||||||            ::.|||
Zfish   384 VIRVWFCNRRQKEKRINPPNNGSAASTPIKAIFSPT 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nub	NP_001097153.1	DUF4472	315..>399	CDD:291409
		POU	791..855	CDD:197673	61/63 (97%)
		Homeobox	886..939	CDD:278475	43/53 (81%)
pou2f1b	XP_005167869.1	TFIIA	59..>226	CDD:281188	56/262 (21%)
		POU	236..309	CDD:197673	68/72 (94%)
		Homeobox	343..397	CDD:278475	43/53 (81%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	141	1.000	Domainoid score	I4662
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6509
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11636
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2466
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.010