DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nub and pou3f2a

DIOPT Version :9

Sequence 1:	NP_001097153.1	Gene:	nub / 34669	FlyBaseID:	FBgn0085424	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_571364.1	Gene:	pou3f2a / 30547	ZFINID:	ZDB-GENE-980526-139	Length:	337	Species:	Danio rerio

Alignment Length:	353	Identity:	148/353 - (41%)
Similarity:	180/353 - (50%)	Gaps:	53/353 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   620 TQQFNSYMELLRSGSLGLAQDDPALTAQVAAAQFLMQSQ---LQA----LSQASQQLQALQKQQQ 677
            |...|.|..|..|...|..|..|  ......|..|:||:   ||:    |..|.|.|.|
Zfish     3 TAASNHYSILTSSAEPGSMQQTP--PPAYRDAHSLLQSEYTTLQSSGGTLGHAHQWLTA------ 59

  Fly   678 RQVDEPLQLNHKMTQQPRSSTPHSIRSPIAIRSPASSPQQLH------HHHHHPLQITPPSSAAS 736
                   .|:|.....|..::|...:....:.....||:|.|      ||.....:.|..:...|
Zfish    60 -------ALSHGGEGSPWPASPLGEQDIKPVEELQHSPRQAHLVPQSQHHETAAWRATTTAHMPS 117

  Fly   737 LKLSG--MLTPSTPTSGTQMSQGTTTPQPKTVASAAAARAAGEP----SPEETTDLEELEQFAKT 795
            :..|.  .|..|.|..|....:...:|.         ....|.|    |.|:|...::||||||.
Zfish   118 MSTSNGQSLIYSQPGYGEMHHEEHHSPH---------LSEHGHPQSLHSDEDTPTSDDLEQFAKQ 173

  Fly   796 FKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLQKWLDDADRTIQA 860
            ||||||||||||.|||||:|.||||.||||||.|||||.|||||||||||||.|||::||    :
Zfish   174 FKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEAD----S 234

  Fly   861 TGGVFDPAALQATVSTPEIIGRRRKKRTSIETTIRGALEKAFLANQKPTSEEITQLADRLSMEKE 925
            |.|  .|.:|....:.    ||:||||||||.:::||||..||...||.:.||..|||.|.:|||
Zfish   235 TSG--SPTSLDKIAAQ----GRKRKKRTSIEVSVKGALESHFLKCPKPGASEINSLADSLQLEKE 293

  Fly   926 VVRVWFCNRRQKEKRINPSLDSPTGADD 953
            |||||||||||||||:.|......|::|
Zfish   294 VVRVWFCNRRQKEKRMTPQNGPMAGSED 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nub	NP_001097153.1	DUF4472	315..>399	CDD:291409
		POU	791..855	CDD:197673	53/63 (84%)
		Homeobox	886..939	CDD:278475	35/52 (67%)
pou3f2a	NP_571364.1	POU	159..233	CDD:197673	57/73 (78%)
pou3f2a	NP_571364.1	Homeobox	254..307	CDD:278475	35/52 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810