DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nub and pou3f1

DIOPT Version :9

Sequence 1:	NP_001097153.1	Gene:	nub / 34669	FlyBaseID:	FBgn0085424	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_571236.1	Gene:	pou3f1 / 30398	ZFINID:	ZDB-GENE-980526-372	Length:	368	Species:	Danio rerio

Alignment Length:	386	Identity:	154/386 - (39%)
Similarity:	191/386 - (49%)	Gaps:	72/386 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   592 NNPLLTGSLSPQDFAQFHQLLQQRQVALTQQFNSYMELLRSG-----SLGLAQDDPALTAQVAAA 651
            ||.|.:..|...|..:.||....|:|. ....:.|::.|.:.     ||...|..|.......:.
Zfish    11 NNSLPSNPLMHPDSDRMHQGTTYREVQ-KMMHHEYLQGLATNTGHPMSLTHHQWLPTSNTDWTSG 74

  Fly   652 QFLMQSQLQALSQASQQLQALQKQQQRQVDEPLQLNHKMTQQPRSSTPHSIRSPIAIRSPAS--- 713
            ..:.|::....|..|::.......:...|.:|.|.:|..:..|  :|.|.: ||:   ||||
Zfish    75 THIGQAEHNKASVQSREDLGNGYHRSHLVHQPTQNSHHGSWAP--TTTHHL-SPL---SPASNGH 133

  Fly   714 -------------SPQ-QLHHHHHHPLQITPPSSAASLKLSGMLTPSTPTSGTQMSQGTTTPQPK 764
                         ||| .|||....||.     ..|....:.|.:|..|.|..|
Zfish   134 QSLVYSQTGYTMLSPQPSLHHGLRDPLH-----DDAGSHDNQMESPQQPFSHHQ----------- 182

  Fly   765 TVASAAAARAAGEPSPEETTDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISR 829
                        :.|.|:....::||||||.||||||||||||.|||||:|.||||.||||||.|
Zfish   183 ------------DHSDEDAPSSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICR 235

  Fly   830 FEALNLSFKNMCKLKPLLQKWLDDADRTIQATGGV--FDPAALQATVSTPEIIGRRRKKRTSIET 892
            ||||.|||||||||||||.|||::.|..   ||..  .|..|.|         ||:||||||||.
Zfish   236 FEALQLSFKNMCKLKPLLNKWLEETDSN---TGSPTNLDKIAAQ---------GRKRKKRTSIEV 288

  Fly   893 TIRGALEKAFLANQKPTSEEITQLADRLSMEKEVVRVWFCNRRQKEKRINP-SLDSPTGAD 952
            .::||||..||...||::.|||.||..|.:||||||||||||||||||:.| .:..||..|
Zfish   289 GVKGALENHFLKCPKPSAHEITTLAGTLQLEKEVVRVWFCNRRQKEKRMTPVGVPHPTMED 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nub	NP_001097153.1	DUF4472	315..>399	CDD:291409
		POU	791..855	CDD:197673	53/63 (84%)
		Homeobox	886..939	CDD:278475	35/52 (67%)
pou3f1	NP_571236.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28		5/16 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	69..88		2/18 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	100..134		13/39 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	147..193		16/73 (22%)
		POU	187..261	CDD:197673	56/73 (77%)
		Homeobox	282..335	CDD:278475	35/52 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810