DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nub and pou3f2b

DIOPT Version :9

Sequence 1:	NP_001097153.1	Gene:	nub / 34669	FlyBaseID:	FBgn0085424	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_571235.1	Gene:	pou3f2b / 30397	ZFINID:	ZDB-GENE-980526-370	Length:	378	Species:	Danio rerio

Alignment Length:	396	Identity:	152/396 - (38%)
Similarity:	191/396 - (48%)	Gaps:	98/396 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   620 TQQFNSYMELLRSGSLGLAQDDPALTAQVAA---AQFLMQS--QLQA----LSQASQQLQAL--- 672
            |...|.|..|..|.|  :...:|....|..|   ||.|:||  .||:    ||.|.|.:.||
Zfish     3 TTASNHYNILTSSPS--IVHSEPGSMQQATAYRDAQTLLQSDYSLQSNSHPLSHAHQWITALSHG 65

  Fly   673 -----------QKQQQRQVDEPL-QLNHKMTQQPRSSTPHSIRSPIAIRSPASSPQQLHHHHHHP 725
                       ::..:..|..|. ::::....|.:|..||.:...              |.:||.
Zfish    66 EGGPWSSSPLGEQDIKPAVQSPRDEMHNSSNLQHQSRPPHLVHQT--------------HGNHHD 116

  Fly   726 LQITPPSSAASLKLSGMLTPSTPTSGTQMSQGTTTPQPKTVASAA-----------AARAA---- 775
            .:....::||.:          |:..|...|.....||....:..           :.|.|
Zfish   117 SRAWRTTTAAHI----------PSMATSNGQSLIYSQPSFSVNGLIPGSGQGIHHHSMRDAHEDH 171

  Fly   776 --------GEP---------------SPEETTDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKL 817
                    |.|               |.|:|...::||||||.||||||||||||.|||||:|.|
Zfish   172 HSPHLSDHGHPPSQHQHQSHQSHHDHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTL 236

  Fly   818 YGNDFSQTTISRFEALNLSFKNMCKLKPLLQKWLDDADRTIQATGGVFDPAALQATVSTPEIIGR 882
            |||.||||||.|||||.|||||||||||||.|||::||    :|.|  .|.:|....:.    ||
Zfish   237 YGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEAD----STSG--SPTSLDKIAAQ----GR 291

  Fly   883 RRKKRTSIETTIRGALEKAFLANQKPTSEEITQLADRLSMEKEVVRVWFCNRRQKEKRINPSLDS 947
            :||||||||.:::||||..||...||.:.|||.|||.|.:||||||||||||||||||:.|....
Zfish   292 KRKKRTSIEVSVKGALESHFLKCPKPAASEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGGP 356

  Fly   948 PTGADD 953
            ..|.:|
Zfish   357 LPGTED 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nub	NP_001097153.1	DUF4472	315..>399	CDD:291409
		POU	791..855	CDD:197673	53/63 (84%)
		Homeobox	886..939	CDD:278475	36/52 (69%)
pou3f2b	NP_571235.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28		7/26 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	86..118		8/45 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..205		7/53 (13%)
		POU	200..274	CDD:197673	57/73 (78%)
		Homeobox	295..348	CDD:278475	36/52 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	347..378		6/16 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810