DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nub and pou3f3a

DIOPT Version :9

Sequence 1:	NP_001097153.1	Gene:	nub / 34669	FlyBaseID:	FBgn0085424	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_571225.2	Gene:	pou3f3a / 30386	ZFINID:	ZDB-GENE-980526-220	Length:	446	Species:	Danio rerio

Alignment Length:	408	Identity:	162/408 - (39%)
Similarity:	199/408 - (48%)	Gaps:	101/408 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   544 STTPNSMAAAAAAAAAVASTMGSGISPLLALPGMSSPQAQLAAAGLGMNNPLLTGSLSPQDFAQF 608
            ::.|::.|||||||||.|:..||        |..|||        :||     .||...||.
Zfish    80 TSLPHAAAAAAAAAAAAAAEAGS--------PWSSSP--------VGM-----AGSPQQQDV--- 120

  Fly   609 HQLLQQRQVALTQQFNSYMELLRSGS--------LGLAQDDPALTAQVAAAQFLMQSQLQALSQA 665
                         :.:|..|.|.||:        ||..|...:......|      |.:..::..
Zfish   121 -------------KSSSNREDLHSGTALHHRPSHLGAHQSHQSAWGGTTA------SHISTITGG 166

  Fly   666 SQQLQALQKQQQRQVDEPLQLNHKMTQQPRSSTPHSIRSPIAIRSPASSPQQLHHHHHHPLQITP 730
            .|     |.||.....:|    ...|.....:.|.|:..|..:|  ..||:..||||||..|...
Zfish   167 QQ-----QSQQSLIYSQP----GGFTVNGMLNPPGSLVHPGLMR--GESPEMDHHHHHHHHQQQH 220

  Fly   731 PSSAASLKLSGMLTPSTPTSGTQMSQGTTTPQPKTVASAAAARAAGEPSPEETTDLEELEQFAKT 795
            |......:                             ..|...:....|.|:|...::||||||.
Zfish   221 PHHHHHHQ-----------------------------HHAGVNSHDSHSDEDTPTSDDLEQFAKQ 256

  Fly   796 FKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLQKWLDDADRTIQA 860
            ||||||||||||.|||||:|.||||.||||||.|||||.|||||||||||||.|||::||.|..:
Zfish   257 FKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSTTGS 321

  Fly   861 TGGVFDPAALQATVSTPEIIGRRRKKRTSIETTIRGALEKAFLANQKPTSEEITQLADRLSMEKE 925
            ...: |..|.|         ||:||||||||.:::||||..||...||:::|||.|||.|.:|||
Zfish   322 PTSI-DKIAAQ---------GRKRKKRTSIEVSVKGALESHFLKCPKPSAQEITSLADNLQLEKE 376

  Fly   926 VVRVWFCNRRQKEKRINP 943
            |||||||||||||||:.|
Zfish   377 VVRVWFCNRRQKEKRMTP 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nub	NP_001097153.1	DUF4472	315..>399	CDD:291409
		POU	791..855	CDD:197673	53/63 (84%)
		Homeobox	886..939	CDD:278475	36/52 (69%)
pou3f3a	NP_571225.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..43
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	102..172		23/117 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	186..248		18/92 (20%)
		POU	242..316	CDD:197673	57/73 (78%)
		Homeobox	337..390	CDD:278475	36/52 (69%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810