DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nub and pou5f3

DIOPT Version :9

Sequence 1:	NP_001097153.1	Gene:	nub / 34669	FlyBaseID:	FBgn0085424	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_571187.1	Gene:	pou5f3 / 30333	ZFINID:	ZDB-GENE-980526-485	Length:	472	Species:	Danio rerio

Alignment Length:	336	Identity:	130/336 - (38%)
Similarity:	175/336 - (52%)	Gaps:	66/336 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   642 PALTAQVAAAQFLMQ--SQLQALSQASQQLQ-ALQKQQQRQVDEPLQLNHKMTQQ-----PRSST 698
            |..|.|||.|....|  :....:.:..:|:: ..:.:.::.|:|.....:|...|     ..||.
Zfish    96 PEFTGQVAGATAATQPANISPPIGETREQIKMPSEVKTEKDVEEYGNEENKPPSQYHLTAGTSSV 160

  Fly   699 PHSIR-------------SPIAIRSPASSPQQLHHHHHHPLQITPPSSAASLKLSGMLTPSTPTS 750
            |..:.             |.|..::..|.              .||:.:||   |..|:||.|.:
Zfish   161 PTGVNYYTPWNPNFWPGLSQITAQANISQ--------------APPTPSAS---SPSLSPSPPGN 208

  Fly   751 GTQ----MSQGTTTPQPKTVASAAAARAAGEPS-------PEETTDLEELEQFAKTFKQRRIKLG 804
            |..    .|.||....|...|. :|.|::|..|       .|||...|:||||||..|.:||.||
Zfish   209 GFGSPGFFSGGTAQNIPSAQAQ-SAPRSSGSSSGGCSDSEEEETLTTEDLEQFAKELKHKRITLG 272

  Fly   805 FTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLQKWLDDADRTIQATGGVFDPAA 869
            |||.|||||:|.|||..||||||.|||||.||||||||||||||:||::|:.:       .:|..
Zfish   273 FTQADVGLALGNLYGKMFSQTTICRFEALQLSFKNMCKLKPLLQRWLNEAENS-------ENPQD 330

  Fly   870 L----QATVSTPEIIGRRRKKRTSIETTIRGALEKAFLANQKPTSEEITQLADRLSMEKEVVRVW 930
            :    :..|.|     |:||:|||:|.|:|.|||..|:...||.:.|||.::|.|.:|::|||||
Zfish   331 MYKIERVFVDT-----RKRKRRTSLEGTVRSALESYFVKCPKPNTLEITHISDDLGLERDVVRVW 390

  Fly   931 FCNRRQKEKRI 941
            |||||||.||:
Zfish   391 FCNRRQKGKRL 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nub	NP_001097153.1	DUF4472	315..>399	CDD:291409
		POU	791..855	CDD:197673	48/63 (76%)
		Homeobox	886..939	CDD:278475	30/52 (58%)
pou5f3	NP_571187.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	127..154		4/26 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	187..255		23/85 (27%)
		POU	259..323	CDD:197673	48/63 (76%)
		Homeobox	346..399	CDD:278475	30/52 (58%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810