DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nub and POU2F3

DIOPT Version :9

Sequence 1:	NP_001097153.1	Gene:	nub / 34669	FlyBaseID:	FBgn0085424	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_001231611.1	Gene:	POU2F3 / 25833	HGNCID:	19864	Length:	438	Species:	Homo sapiens

Alignment Length:	379	Identity:	161/379 - (42%)
Similarity:	202/379 - (53%)	Gaps:	100/379 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   628 ELLRSGSLGLAQDDPALTAQVA------AAQFLMQSQLQALSQASQQLQALQKQQQRQVDEPLQL 686
            ::..||.:..:.|..:..:||.      ...|..|.:.:.||.:.||                .|
Human    12 DIKMSGDVADSTDARSTLSQVEPGNDRNGLDFNRQIKTEDLSDSLQQ----------------TL 60

  Fly   687 NHK---MTQQPRSSTPHSIRSPIAIRSPASSPQQLHHHHHHPLQ--ITPPSSAASL--------- 737
            :|:   ::|.|...:.:.:....|  ||......|     ||||  :..|....|:
Human    61 SHRPCHLSQGPAMMSGNQMSGLNA--SPCQDMASL-----HPLQQLVLVPGHLQSVSQFLLSQTQ 118

  Fly   738 ---------------KLSGMLTPST--------------PTSGTQ--MSQGTTTPQPKTVASAAA 771
                           :.||:|.|.|              |.|..:  :......|.||.:.|:..
Human   119 PGQQGLQPNLLPFPQQQSGLLLPQTGPGLASQAFGHPGLPGSSLEPHLEASQHLPVPKHLPSSGG 183

  Fly   772 ARAAGEPSPEETTDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLS 836
            |        :|.:||||||:|||||||||||||||||||||||||||||||||||||||||||||
Human   184 A--------DEPSDLEELEKFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLS 240

  Fly   837 FKNMCKLKPLLQKWLDDADRTIQATGGVFDPAALQATVSTP-------EIIGRRRKKRTSIETTI 894
            |||||||||||:|||:||:.:..      ||     :||||       |:.||:|||||||||.|
Human   241 FKNMCKLKPLLEKWLNDAESSPS------DP-----SVSTPSSYPSLSEVFGRKRKKRTSIETNI 294

  Fly   895 RGALEKAFLANQKPTSEEITQLADRLSMEKEVVRVWFCNRRQKEKRINPSLDSP 948
            |..|||.|..|.||:||||:.:|::|||||||||||||||||||||||..:.:|
Human   295 RLTLEKRFQDNPKPSSEEISMIAEQLSMEKEVVRVWFCNRRQKEKRINCPVATP 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nub	NP_001097153.1	DUF4472	315..>399	CDD:291409
		POU	791..855	CDD:197673	60/63 (95%)
		Homeobox	886..939	CDD:278475	39/52 (75%)
POU2F3	NP_001231611.1	POU	185..259	CDD:197673	67/73 (92%)
POU2F3	NP_001231611.1	Homeobox	286..339	CDD:278475	39/52 (75%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	142	1.000	Domainoid score	I4687
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003004
OrthoInspector	1	1.000	-	-		mtm8655
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11636
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.910