DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nub and Pou6f2

DIOPT Version :9

Sequence 1:	NP_001097153.1	Gene:	nub / 34669	FlyBaseID:	FBgn0085424	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	XP_036013870.1	Gene:	Pou6f2 / 218030	MGIID:	2443631	Length:	728	Species:	Mus musculus

Alignment Length:	985	Identity:	217/985 - (22%)
Similarity:	330/985 - (33%)	Gaps:	362/985 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 QHHHQQQHQLLLQQQL-LQQHVANSSPLQHLSNLFGQ-HLPTHSLQHLIAAEYWQQQQQQPAATI 117
            |.||.....|..||.. ..|.|....|:     :.|| ..|..|::..:.||.   :.:..|||.
Mouse    11 QRHHMMDCDLPAQQDTGTMQAVIGQDPM-----IAGQVSKPLLSVRSEMNAEL---RGEDKAATS 67

  Fly   118 KSE--PTTQSVAATSVFSFTPQQHVNFAASLVALQQNDALPE----------ETMATATATPTPA 170
            .||  ....:.|.::....||       :.|...:.|..||:          :|..|....|.|.
Mouse    68 DSELNEPLLAPAESNDSEDTP-------SKLFGARGNTVLPDPGTPDQHQACQTHPTFPVGPQPL 125

  Fly   171 TTASGAATAAAVATSPAAATTLKAPTATQAAATMDDIDDDDDDSNNGGHMQNAGVGNFKFEPGQQ 235
            .||...|:|.| ...|.....|..|..                              ..|....|
Mouse   126 LTAQQLASAVA-GVMPGGPPALNQPIL------------------------------IPFNMAGQ 159

  Fly   236 LGTPANEAVLTSSEENKDG-TLTAVDTNMRDVSANHSSSFLSSSPASSTLVSCHSPSPPLPLLAD 299
            ||             .:.| .||....|:.::..      |.::.|:..:::       |||
Mouse   160 LG-------------GQQGLVLTLPTANLTNIQG------LVAAAAAGGIMT-------LPL--- 195

  Fly   300 QDDGTRRMRDKKLTLELKLQSCDEYVEQPKDKGAERLQPAQIANDNAPSPLHLKLEEQDEQEQAD 364
                                              :.||.....|........|:|::|.:|:|
Mouse   196 ----------------------------------QNLQATSSLNSQLQQLQQLQLQQQQQQQQ-- 224

  Fly   365 VKDKVLELTGAAVALYGHLNNASKDVRDLEQCLKLQDPNDISRLSRSPSPLQSNASDCDDNNSSV 429
                                      :..:|..:.|.|.. ...|:.|.|    ||.....:...
Mouse   225 --------------------------QQQQQQQQQQQPPP-PPTSQHPQP----ASQAPPQSQPT 258

  Fly   430 GTSSDRCRSPLSPALSLSHQQAKRQLMSLQPHPAHHHHNPHHLNHLNHHQYKQEEDYDDANGGAL 494
            ........|...||.....|||      .||    ..|.||     :|.|
Mouse   259 PPHQPPPASQQLPAPPAQLQQA------TQP----QQHQPH-----SHPQ--------------- 293

  Fly   495 NLTSDNSRHSTQSPSNSVKSATASPVPVISVPSPVPP------MISPVLAPSGCGSTTPNSMAAA 553
            |.|.:....:.||.|...|   .||.|..|:|||:.|      :.:|:.:.:...:....|:|::
Mouse   294 NQTQNQPSPTQQSSSPPQK---PSPSPGHSLPSPLTPPNPLQLVNNPLASQAAAAAAAMGSIASS 355

  Fly   554 AAAAAAVASTMG-------------SGISPLLALPGMSSPQAQLAAAGLGMNNPLLTGSLSPQDF 605
            .|...|::|..|             .|..||:..||.|| ||.....||.:.      .::|
Mouse   356 QAFGNALSSLQGVTGQLVTNAQGQIIGTIPLMPNPGPSS-QAASGTQGLQVQ------PITP--- 410

  Fly   606 AQFHQLL--QQRQVALTQQFNSYMELLRSGSLGLAQDDPALTAQVAAAQFLMQSQLQALSQASQQ 668
                |||  .|.|:..|...|..:.::.:..:.|:...|        .|.|.||...::.||..|
Mouse   411 ----QLLTNAQGQIIATVIGNQILPVINTQGITLSPIKP--------GQQLHQSSQTSVGQAGTQ 463

  Fly   669 LQALQKQQQRQVDEPLQLNHKMTQQPRSSTPHSIRSPIAIRSPASSPQQLHHHHHHPLQITPPSS 733
                        ...|.|.|     .:::|.||     .:|..:||                 ||
Mouse   464 ------------GNLLHLAH-----GQAATSHS-----PVRQASSS-----------------SS 489

  Fly   734 AASLKLSGMLTPSTPTSGTQMSQGTTTPQPKTVASAAAARAAGEPSPEETTDLEELEQFAKTFKQ 798
            ::|             |.:.:|.|.....|:|        ||||   .:..:|||:.:|||.||.
Mouse   490 SSS-------------SSSALSVGQLVSNPQT--------AAGE---VDGVNLEEIREFAKAFKI 530

  Fly   799 RRIKLGFTQGDVGLAMGKLYGNDFSQTTI------------------------------------ 827
            ||:.||.||..||.|:....|..:||:.|
Mouse   531 RRLSLGLTQTQVGQALSATEGPAYSQSAICRHTILRSHFFLPQEAQENTIASSLTAKLNPGLLYP 595

  Fly   828 SRFEALNLSFKNMCKLKPLLQKWLDDADRTIQATGGVFDPAALQATVSTPEIIG----RRRKKRT 888
            :|||.|:::.|:..|:||:|::|:.:|:...:        |.:|   :..|.||    ::||:||
Mouse   596 ARFEKLDITPKSAQKIKPVLERWMAEAEARHR--------AGMQ---NLTEFIGSEPSKKRKRRT 649

  Fly   889 SIETTIRGALEKAFLANQKPTSEEITQLADRLSMEKEVVRVWFCNRRQKEKR------------- 940
            |........|...|..|..|:.:|:|::|::|:.::|||||||||:||..|.
Mouse   650 SFTPQALEILNAHFEKNTHPSGQEMTEIAEKLNYDREVVRVWFCNKRQALKNTIKRLKQHEPTSA 714

  Fly   941 --INPSLDSP 948
              :.|..|||
Mouse   715 APLEPLADSP 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nub	NP_001097153.1	DUF4472	315..>399	CDD:291409	9/83 (11%)
		POU	791..855	CDD:197673	28/99 (28%)
		Homeobox	886..939	CDD:278475	22/52 (42%)
Pou6f2	XP_036013870.1	Pou	514..623	CDD:419906	31/108 (29%)
Pou6f2	XP_036013870.1	Homeobox	647..701	CDD:395001	22/53 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810