DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nub and Pou4f3

DIOPT Version :9

Sequence 1:	NP_001097153.1	Gene:	nub / 34669	FlyBaseID:	FBgn0085424	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_620395.2	Gene:	Pou4f3 / 18998	MGIID:	102523	Length:	338	Species:	Mus musculus

Alignment Length:	365	Identity:	118/365 - (32%)
Similarity:	171/365 - (46%)	Gaps:	71/365 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   609 HQLLQQRQVALTQQFNSYMELLRSGSLGLAQ---DDPALTAQVAAAQFLMQSQLQALSQASQQLQ 670
            |.:||:      .:|:|    |.|||..:.:   ..|.|...:..:   ....|.|.::|...:.
Mouse    13 HPVLQE------PKFSS----LHSGSEAMRRVCLPAPQLQGNIFGS---FDESLLARAEALAAVD 64

  Fly   671 ALQKQQQRQVDEPLQLNHKMTQQPRSSTPHSIRSPIAIRSPASSPQQLHHHHHHPL--------- 726
            .:...:.... :|....|.|:..|.:||..::        |.|.|..|..|.||.:
Mouse    65 IVSHGKNHPF-KPDATYHTMSSVPCTSTSPTV--------PISHPAALTSHPHHAVHQGLEGDLL 120

  Fly   727 -QITPPSSAASLKLSGMLTPSTPTSGTQ-----------MSQGTTTPQPKTVASAAAARAAGEPS 779
             .|:|     :|.:||:..|.......|           :.|......|..||..:|..|.   .
Mouse   121 EHISP-----TLSVSGLGAPEHSVMPAQIHPHHLGAMGHLHQAMGMSHPHAVAPHSAMPAC---L 177

  Fly   780 PEETTDLEELEQFAKTFKQRRIKLGFTQGDVGLAMG--KLYG-NDFSQTTISRFEALNLSFKNMC 841
            .:..:|..|||.||:.|||||||||.||.|||.|:.  |:.| ...||:||.|||:|.||..||.
Mouse   178 SDVESDPRELEAFAERFKQRRIKLGVTQADVGAALANLKIPGVGSLSQSTICRFESLTLSHNNMI 242

  Fly   842 KLKPLLQKWLDDADRTIQATGGVFDPAALQATVSTPEII--GRRRKKRTSIETTIRGALEKAFLA 904
            .|||:||.||::|:            ||.:...|.||:.  ..|::|||||....:.:||..|..
Mouse   243 ALKPVLQAWLEEAE------------AAYREKNSKPELFNGSERKRKRTSIAAPEKRSLEAYFAI 295

  Fly   905 NQKPTSEEITQLADRLSMEKEVVRVWFCNRRQKEKRINPS 944
            ..:|:||:|..:|::|.::|.||||||||:|||:||:..|
Mouse   296 QPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYS 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nub	NP_001097153.1	DUF4472	315..>399	CDD:291409
		POU	791..855	CDD:197673	38/66 (58%)
		Homeobox	886..939	CDD:278475	26/52 (50%)
Pou4f3	NP_620395.2	POU-IV box	56..65		1/8 (13%)
		POU	179..256	CDD:197673	42/76 (55%)
		Homeobox	277..331	CDD:395001	26/53 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810