DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nub and Pou3f3

DIOPT Version :9

Sequence 1:	NP_001097153.1	Gene:	nub / 34669	FlyBaseID:	FBgn0085424	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_032926.2	Gene:	Pou3f3 / 18993	MGIID:	102564	Length:	497	Species:	Mus musculus

Alignment Length:	440	Identity:	165/440 - (37%)
Similarity:	205/440 - (46%)	Gaps:	120/440 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   547 PNSMAAAAAAAAAV--ASTMGSGISPLLALPGMS-SPQAQLAAAGLGMNNPLLTGSLSPQDFAQF 608
            |::.|||||||||.  ||:..||     :..||: |||............|.:.|....:|
Mouse   101 PHAAAAAAAAAAAAVEASSPWSG-----SAVGMAGSPQQPPQPPPPPPQGPDVKGGAGRED---- 156

  Fly   609 HQLLQQRQVALTQQFNSYMELLRSGS---------LGLAQDDP---------ALTAQVAAAQFLM 655
                                 |.:|:         ||.....|         |..|..|||
Mouse   157 ---------------------LHAGTALHHRGPPHLGPPPPPPHQGHPGGWGAAAAAAAAA---- 196

  Fly   656 QSQLQALSQASQQLQALQKQQQRQVDEPLQLNHKMTQQPRSSTPHSIRS---------------- 704
                 |.:.|:..|.::...||   ..|..|   :..||...|.:.:.|
Mouse   197 -----AAAAAAAHLPSMAGGQQ---PPPQSL---LYSQPGGFTVNGMLSAPPGPGGGGGGAGGGA 250

  Fly   705 -----PIAIRSPASSPQQLHHHHHHPLQITPPSSAASLKLSGMLTPSTPTSGTQMSQGTTTPQPK 764
                 |..:|.......:.||||||.....||.                   ...:||   |...
Mouse   251 QSLVHPGLVRGDTPELAEHHHHHHHHAHPHPPH-------------------PHHAQG---PPHH 293

  Fly   765 TVASAAAARAAGEP-SPEETTDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTIS 828
            ....|.....:.:| |.|:|...::||||||.||||||||||||.|||||:|.||||.||||||.
Mouse   294 GGGGAGPGLNSHDPHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTIC 358

  Fly   829 RFEALNLSFKNMCKLKPLLQKWLDDADRTIQATGGVFDPAALQATVSTPEIIGRRRKKRTSIETT 893
            |||||.|||||||||||||.|||::||   .:||   .|.::....:.    ||:||||||||.:
Mouse   359 RFEALQLSFKNMCKLKPLLNKWLEEAD---SSTG---SPTSIDKIAAQ----GRKRKKRTSIEVS 413

  Fly   894 IRGALEKAFLANQKPTSEEITQLADRLSMEKEVVRVWFCNRRQKEKRINP 943
            ::||||..||...||:::|||.|||.|.:||||||||||||||||||:.|
Mouse   414 VKGALESHFLKCPKPSAQEITNLADSLQLEKEVVRVWFCNRRQKEKRMTP 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nub	NP_001097153.1	DUF4472	315..>399	CDD:291409
		POU	791..855	CDD:197673	53/63 (84%)
		Homeobox	886..939	CDD:278475	36/52 (69%)
Pou3f3	NP_032926.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	32..62
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..189		15/97 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	230..316		19/107 (18%)
		POU	311..385	CDD:197673	57/73 (78%)
		Homeobox	406..460	CDD:395001	37/53 (70%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	458..497		4/6 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810