DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nub and Pou3f1

DIOPT Version :9

Sequence 1:	NP_001097153.1	Gene:	nub / 34669	FlyBaseID:	FBgn0085424	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_035271.1	Gene:	Pou3f1 / 18991	MGIID:	101896	Length:	449	Species:	Mus musculus

Alignment Length:	445	Identity:	161/445 - (36%)
Similarity:	207/445 - (46%)	Gaps:	82/445 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   541 GCGSTTPNSMAAAAAAAAAVASTMGSG-----ISPLLALPGMSSPQAQLAAAG--LGMNNP--LL 596
            |.|.|.|.....|||||||.|..:.:|     :..|:....:.      |.||  :|:.:|  |.
Mouse    15 GAGGTGPLMHPDAAAAAAAAAERLHAGAAYREVQKLMHHEWLG------AGAGHPVGLAHPQWLP 73

  Fly   597 TGSLSPQDFAQFHQLLQQRQVALTQQFNSYMELLRSGSLGLAQDDPALTAQVAAAQFLMQSQLQA 661
            ||.....|:|.                ..::|..::|..|..:.|.........|:.:.|....|
Mouse    74 TGGGGGGDWAG----------------GPHLEHGKAGGGGTGRADDGGGGGGFHARLVHQGAAHA 122

  Fly   662 LSQASQQLQALQKQQQRQVDEPLQLNHKMTQQPRSSTPHSIRSPIAIRSPASSP----------- 715
            .:..:|...|            ..|...|:..|.:...|. ..|:.:.:.|:.|
Mouse   123 GAAWAQGGTA------------HHLGPAMSPSPGAGGGHQ-PQPLGLYAQAAYPGGGGGGLAGML 174

  Fly   716 --------QQLHHHHH---HPLQITPPSSAASLKLSGMLTPSTPTSGTQMSQGTTTPQPKTVASA 769
                    ..|||..|   |..|: .||....|...|.........|...:.....|     .:.
Mouse   175 AAGGGGAGPGLHHALHEDGHEAQL-EPSPPPHLGAHGHAHGHAHAGGLHAAAAHLHP-----GAG 233

  Fly   770 AAARAAGEPSPEETTDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALN 834
            ....:.||.|.|:....::||||||.||||||||||||.|||||:|.||||.||||||.|||||.
Mouse   234 GGGSSVGEHSDEDAPSSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQ 298

  Fly   835 LSFKNMCKLKPLLQKWLDDADRTIQATGGVFDPAALQATVSTPEIIGRRRKKRTSIETTIRGALE 899
            |||||||||||||.|||::.|.:..:...: |..|.|         ||:||||||||..::||||
Mouse   299 LSFKNMCKLKPLLNKWLEETDSSSGSPTNL-DKIAAQ---------GRKRKKRTSIEVGVKGALE 353

  Fly   900 KAFLANQKPTSEEITQLADRLSMEKEVVRVWFCNRRQKEKRINPSLDSPTGADDD 954
            ..||...||::.|||.|||.|.:||||||||||||||||||:.|:..:.....||
Mouse   354 SHFLKCPKPSAHEITGLADSLQLEKEVVRVWFCNRRQKEKRMTPAAGAGHPPMDD 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nub	NP_001097153.1	DUF4472	315..>399	CDD:291409
		POU	791..855	CDD:197673	53/63 (84%)
		Homeobox	886..939	CDD:278475	36/52 (69%)
Pou3f1	NP_035271.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		3/6 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	76..108		6/47 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	132..152		5/32 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	184..251		16/72 (22%)
		POU	245..319	CDD:197673	56/73 (77%)
		Homeobox	340..393	CDD:278475	36/52 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	393..449		5/16 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810