DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nub and ceh-18

DIOPT Version :9

Sequence 1:	NP_001097153.1	Gene:	nub / 34669	FlyBaseID:	FBgn0085424	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_741758.1	Gene:	ceh-18 / 180671	WormBaseID:	WBGene00000441	Length:	542	Species:	Caenorhabditis elegans

Alignment Length:	363	Identity:	124/363 - (34%)
Similarity:	183/363 - (50%)	Gaps:	107/363 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   678 RQVDEPLQLNHK-------MTQQ-----------PRSSTPHSIRSPIAIR-SPA-------SSPQ 716
            |:|.:.||.||.       :.||           |.|:..:.:.:||..: ||.       :||:
Worm   135 RRVADMLQGNHNGSLNSHFLQQQFAAFKETVDPTPVSTNGNGLLTPITTQLSPLFTSTDAFNSPE 199

  Fly   717 QLHHHHHHPLQ--ITPP----------SSAASLKLSGMLTPS---------TPTSGTQMSQGTTT 760
            :|       ||  :||.          :|.:.|..|.::.||         |||..|    .:.|
Worm   200 KL-------LQAIMTPSLGFLGANGLGASNSGLLSSPLIAPSPTLLQSLMNTPTQPT----ASLT 253

  Fly   761 P-----QPKTVASAAAAR-----------AAGEPSPEETTDLEELEQFAKTFKQRRIKLGFTQGD 809
            |     :|..|:....|.           .|...|.::..|:.|||.||:|||::|||.||||||
Worm   254 PKKAENRPPVVSQTLKASKRRLFDDTSRIEAASMSGDDRIDMNELEAFAQTFKKQRIKFGFTQGD 318

  Fly   810 VGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLQKWLDDADRTIQATGG-----VFDPAA 869
            ||:|:||.||.|||||||||||||||||||||||:|||::||.|.:..|:  ||     :.|...
Worm   319 VGVALGKRYGTDFSQTTISRFEALNLSFKNMCKLRPLLKEWLADVEMAIE--GGATVTDLIDKKT 381

  Fly   870 LQ---------------------ATVSTPEIIGR-----RRKKRTSIETTIRGALEKAFLANQKP 908
            :.                     ::|:...::.|     ||:|||:::...|.||:..|..|.:|
Worm   382 IHNGNHHTIHHVDIHETSISNSISSVTASSLLSREQHVKRRRKRTNLDMNQRNALDTFFALNPRP 446

  Fly   909 TSEEITQLADRLSMEKEVVRVWFCNRRQKEKRINPSLD 946
            ..:::|.:|:.|.::::||||||||||||.:|::..::
Worm   447 DHDKMTDIANSLELDRDVVRVWFCNRRQKMRRVDEPIE 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nub	NP_001097153.1	DUF4472	315..>399	CDD:291409
		POU	791..855	CDD:197673	50/63 (79%)
		Homeobox	886..939	CDD:278475	24/52 (46%)
ceh-18	NP_741758.1	POU	290..364	CDD:197673	54/73 (74%)
ceh-18	NP_741758.1	Homeobox	424..477	CDD:278475	24/52 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	118	1.000	Domainoid score	I3642
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11636
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010