DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nub and ceh-6

DIOPT Version :9

Sequence 1:	NP_001097153.1	Gene:	nub / 34669	FlyBaseID:	FBgn0085424	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_492304.1	Gene:	ceh-6 / 172640	WormBaseID:	WBGene00000431	Length:	380	Species:	Caenorhabditis elegans

Alignment Length:	432	Identity:	161/432 - (37%)
Similarity:	207/432 - (47%)	Gaps:	104/432 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   536 VLAPSGCGSTTPNSMAAAAAAAAAVASTMGSGISPLLALPGMS-----SPQAQLAAAGLGMNNPL 595
            :|.||  .|:.|:|::|:|:.:.. :|..|||||....||...     ..:.::.||....
Worm     1 MLIPS--SSSIPSSLSASASDSEP-SSLNGSGISDQNILPNYHLHHHLINENEMEAANYAQ---- 58

  Fly   596 LTGSLSP-----QDFAQFHQLLQQRQV--ALTQQFNSYMELLRSGSLGLAQDDP------ALTAQ 647
               .:.|     ||:.....|.||.|:  .|.|...:|..        |||..|      ..||.
Worm    59 ---VIKPTCEAFQDWPHTPMLYQQPQLHFMLPQHDWAYPH--------LAQSLPPPHHLTPSTAA 112

  Fly   648 VAAAQFLMQSQLQALSQASQQLQALQKQQQRQVDEPLQLNHKMTQQPRSSTPHSIRSPIAIRSPA 712
            ||||....||.:  ::|.|........|.:::|:.|..:...|...|                ||
Worm   113 VAAATIASQSSI--INQTSVVTSTPSCQIKQEVERPEIIQRLMPPWP----------------PA 159

  Fly   713 SSPQQLHHHHHHPLQITPPSSAASLKLSGMLTPSTPTSGTQMSQGTTTPQPKTVASAAAARAAGE 777
                         .|.:...|.:   :||...|..|.|........|.|
Worm   160 -------------YQFSCDDSGS---VSGAGGPHQPLSDISDDSEQTCP---------------- 192

  Fly   778 PSPEETTDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCK 842
                     ::||.|||.|||||||||:||.|||:|:|.||||.||||||.|||||.||||||||
Worm   193 ---------DDLEGFAKQFKQRRIKLGYTQADVGVALGTLYGNIFSQTTICRFEALQLSFKNMCK 248

  Fly   843 LKPLLQKWLDDADRTIQATGGVFDPAALQATVSTPEIIGRRRKKRTSIETTIRGALEKAFLANQK 907
            |||||.|||::||.|..:....|:....||        ||:||||||||..::..||..|.:|||
Worm   249 LKPLLFKWLEEADSTTGSPNSTFEKMTGQA--------GRKRKKRTSIEVNVKSRLEFHFQSNQK 305

  Fly   908 PTSEEITQLADRLSMEKEVVRVWFCNRRQKEKRINPS-LDSP 948
            |.::||||:|..|.:|||||||||||||||||||.|: .|:|
Worm   306 PNAQEITQVAMELQLEKEVVRVWFCNRRQKEKRIAPNQYDAP 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nub	NP_001097153.1	DUF4472	315..>399	CDD:291409
		POU	791..855	CDD:197673	50/63 (79%)
		Homeobox	886..939	CDD:278475	34/52 (65%)
ceh-6	NP_492304.1	POU	188..261	CDD:197673	54/97 (56%)
ceh-6	NP_492304.1	Homeobox	284..337	CDD:278475	34/52 (65%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810