Protein Alignment nub and POU6F2

DIOPT Version :10

• Sequence 1: NP_001097153.1
• Gene: nub / 34669
• FlyBaseID: FBgn0085424
• Length: 961
• Species: Drosophila melanogaster
• Sequence 2: NP_001357888.1
• Gene: POU6F2 / 11281
• HGNCID: 21694
• Length: 720
• Species: Homo sapiens
• Alignment Length: 975
• Identity: 205/975 - (21%)
• Similarity: 329/975 - (33%)
• Gaps: 376/975 - (38%)

  Fly    57 HHQQQHQLLLQQQLLQQHVANSSPLQHLSNLFGQHLPTHSLQHLIAAEYWQQQQQQPAATIKSEP 121
            |.:..|....:|.::..:::.......:..:.||       ..:||.     |..:|..:::||.
Human     2 HARNPHSPFQRQHMMDCYLSAQQDTGTMQAVIGQ-------DPMIAG-----QVSKPLLSVRSEM 54

  Fly   122 TT----QSVAATSVFSF---------------TPQQHVNFAASLVALQQNDAL-----PEETMAT 162
            ..    :..||||....               ||       :.|...:.|.||     |::..|:
Human    55 NAELRGEDKAATSDSELNEPLLAPVESNDSEDTP-------SKLFGARGNPALSDPGTPDQHQAS 112

  Fly   163 ATATPTPATTASGAATAAAVATSPAAATTLKAPTATQAAATMDDIDDDDDDSNNGGHMQNAGVGN 227
            .|..|.|            |...|..       ||.|.|:.:                  |||
Human   113 QTHPPFP------------VGPQPLL-------TAQQLASAV------------------AGV-- 138

  Fly   228 FKFEPGQQLGTPA-NEAVLTSSEENKDG--------TLTAVDTNMRDVSANHSSSFLSSSPASST 283
               .||   |.|| |:.:|...  |..|        .||....|:.::..      |.::.|:..
Human   139 ---MPG---GPPALNQPILIPF--NMAGQLGGQQGLVLTLPTANLTNIQG------LVAAAAAGG 189

  Fly   284 LVSCHSPSPPLPLLADQDDGTRRMRDKKLTLELKLQSCDEYVEQPKDKGAERLQPAQIANDNAPS 348
            :::       |||                                     :.||.....|... .
Human   190 IMT-------LPL-------------------------------------QNLQATSSLNSQL-Q 209

  Fly   349 PLHLKLEEQDEQEQADVKDKVLELTGAAVALYGHLNNASKDVRDLEQCLKLQDPNDISRLSRSPS 413
            .|.|:|::|.:|:|                                     |.|...:.....|:
Human   210 QLQLQLQQQQQQQQ-------------------------------------QQPPPSTNQHPQPA 237

  Fly   414 PLQSNASDCDDNNSSVGTSSDRCRSPLSPALSL----SHQQAKRQLMSLQPHPAHHHHNPHHLNH 474
            |...:.|.               :.||.|....    :.||.......||..|....|.||
Human   238 PQAPSQSQ---------------QQPLQPTPPQQPPPASQQPPAPTSQLQQAPQPQQHQPH---- 283

  Fly   475 LNHHQYKQEEDYDDANGGALNLTSDNSRHSTQSPSNSVKSATASPVPVISVPSPVPPMISPVLAP 539
             :|.|.:.:..           .:..|....|.||.|......||   ::.|:|:..:.:|:.:.
Human   284 -SHSQNQNQPS-----------PTQQSSSPPQKPSQSPGHGLPSP---LTPPNPLQLVNNPLASQ 333

  Fly   540 SGCGSTTPNSMAAAAAAAAAVASTMG-------------SGISPLLALPGMSSPQAQLAAAGLGM 591
            :...:...:|:|::.|...|::|..|             .|..||:..||.|| ||.....||.:
Human   334 AAAAAAAMSSIASSQAFGNALSSLQGVTGQLVTNAQGQIIGTIPLMPNPGPSS-QAASGTQGLQV 397

  Fly   592 NNPLLTGSLSPQDFAQFHQLL--QQRQVALTQQFNSYMELLRSGSLGLAQDDPALTAQVAAAQFL 654
            .      .::|       |||  .|.|:..|...|..:.::.:..:.|:...|        .|.|
Human   398 Q------PITP-------QLLTNAQGQIIATVIGNQILPVINTQGITLSPIKP--------GQQL 441

  Fly   655 MQSQLQALSQASQQLQALQKQQQRQVDEPLQLNHKMTQQPRSSTPHSIRSPIAIRSPASSPQQLH 719
            .|....::.||:.|            ...|.|.|  :|...|.:|        :|..:||
Human   442 HQPSQTSVGQAASQ------------GNLLHLAH--SQASMSQSP--------VRQASSS----- 479

  Fly   720 HHHHHPLQITPPSSAASLKLSGMLTPSTPTSGTQMSQGTTTPQPKTVASAAAARAAGEPSPEETT 784
                        ||::|             |.:.:|.|.....|:|        ||||   .:..
Human   480 ------------SSSSS-------------SSSALSVGQLVSNPQT--------AAGE---VDGV 508

  Fly   785 DLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTI---------------------- 827
            :|||:.:|||.||.||:.||.||..||.|:....|..:||:.|
Human   509 NLEEIREFAKAFKIRRLSLGLTQTQVGQALSATEGPAYSQSAICRHTILRSHFFLPQEAQENTIA 573

  Fly   828 --------------SRFEALNLSFKNMCKLKPLLQKWLDDADRTIQATGGVFDPAALQATVSTPE 878
                          :|||.|:::.|:..|:||:|::|:.:|:...:        |.:|   :..|
Human   574 SSLTAKLNPGLLYPARFEKLDITPKSAQKIKPVLERWMAEAEARHR--------AGMQ---NLTE 627

  Fly   879 IIG----RRRKKRTSIETTIRGALEKAFLANQKPTSEEITQLADRLSMEKEVVRVWFCNRRQKEK 939
            .||    ::||:|||........|...|..|..|:.:|:|::|::|:.::|||||||||:||..|
Human   628 FIGSEPSKKRKRRTSFTPQALEILNAHFEKNTHPSGQEMTEIAEKLNYDREVVRVWFCNKRQALK 692

  Fly   940  939
            Human   693  692

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nub	NP_001097153.1	POU	791..855	CDD:197673	28/99 (28%)
		Homeodomain	884..940	CDD:459649	25/56 (45%)
POU6F2	NP_001357888.1	Pou	506..615	CDD:473999	31/108 (29%)
		Homeodomain	637..693	CDD:459649	25/56 (45%)