DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nub and pou5f3.3

DIOPT Version :9

Sequence 1:	NP_001097153.1	Gene:	nub / 34669	FlyBaseID:	FBgn0085424	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_001123836.1	Gene:	pou5f3.3 / 100170593	XenbaseID:	XB-GENE-5903504	Length:	423	Species:	Xenopus tropicalis

Alignment Length:	407	Identity:	139/407 - (34%)
Similarity:	195/407 - (47%)	Gaps:	90/407 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   570 PLL----ALPGMS-SPQAQLAAAGLGM--NNPLLTGSLS----PQDFAQFHQLLQQRQVALTQQF 623
            |:|    |.|..| ||       |||.  .|....|:.:    ||.|  ||.     ..|:..::
Frog     4 PVLYNQPAFPNFSYSP-------GLGQEGGNYQYLGNYNAPSYPQPF--FHV-----PPAIKSEY 54

  Fly   624 NSYMELLRSGSLGLAQDDPALTAQVAAAQFLMQSQLQALSQASQQLQALQKQQQRQVDEPLQLNH 688
            .:..| :..||...|..|..|     ...|...:|:.|||......:...::           :|
Frog    55 GAQDE-VTGGSCHAAPFDWHL-----YPHFQFSNQVGALSSGDPSPEGRNEE-----------DH 102

  Fly   689 KMTQQPRSSTPHSIRSPIAIRSPASSPQQLHHHHHHPLQITPPSSAASLKLSGMLTPSTPTSGTQ 753
            ....:.|||...|..||:.       |....:.||.|.|..|...|.     |:.:.:.|..|.:
Frog   103 GSISEERSSGTPSPNSPMV-------PSYAQYWHHAPWQGNPTGQAL-----GLPSRAHPDGGEK 155

  Fly   754 MSQ-----------GTTTPQPKTVASAAAARAAG---EPSP----------EETTDLEELEQFAK 794
            ..|           |.:..:.:.|:||.::||..   .|||          |:.|.|||:|:|||
Frog   156 PQQSDCSPTASLESGASNTEDEEVSSALSSRAERGLCSPSPNNASFGSGNEEDGTTLEEMEEFAK 220

  Fly   795 TFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLQKWLDDADRTIQ 859
            ..||:|:.||:||||:|.|:|.|||..||||||.|||:|.|:|||||||||||::||.:|:....
Frog   221 ELKQKRVALGYTQGDIGHALGILYGKMFSQTTICRFESLQLTFKNMCKLKPLLEQWLGEAENNDN 285

  Fly   860 ATGGVFDPAALQATVSTPEI--IGRRRKKRTSIETTIRGALEKAFLANQKPTSEEITQLADRLSM 922
                      ||..:...::  ..|:||.||..::.::|.||..|:.||||.:.|:.::|..|.:
Frog   286 ----------LQEMIHKAQLEEQNRKRKMRTCFDSVLKGRLEGHFMCNQKPGARELAEIAKELGL 340

  Fly   923 EKEVVRVWFCNRRQKEK 939
            ||:||||||||||||||
Frog   341 EKDVVRVWFCNRRQKEK 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nub	NP_001097153.1	DUF4472	315..>399	CDD:291409
		POU	791..855	CDD:197673	42/63 (67%)
		Homeobox	886..939	CDD:278475	27/52 (52%)
pou5f3.3	NP_001123836.1	PTZ00395	<7..>177	CDD:185594	46/212 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	85..211		31/148 (21%)
		POU	207..281	CDD:197673	48/73 (66%)
		Homeobox	305..357	CDD:365835	27/51 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910