DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nub and pou6f1

DIOPT Version :9

Sequence 1:	NP_001097153.1	Gene:	nub / 34669	FlyBaseID:	FBgn0085424	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	XP_012811781.1	Gene:	pou6f1 / 100126212	XenbaseID:	XB-GENE-854918	Length:	604	Species:	Xenopus tropicalis

Alignment Length:	556	Identity:	141/556 - (25%)
Similarity:	206/556 - (37%)	Gaps:	173/556 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   503 HSTQSPSNSVKSATASPVP-----------VISVPSPVPPMISPVLAPSGCGSTTPNSMAAAA-- 554
            |::..|..::.|....|.|           |..|.:|..|:..|||.|...|.........|.
Frog    92 HASSQPQPTIASFAVQPAPQVLTQENLATLVTGVMAPAGPVAQPVLIPISIGGQVAGQQGLALWN 156

  Fly   555 AAAAAVASTMGSGISPLLALPGMSS----------PQAQLAAAGLGMNNPLLTGSLSPQDFAQFH 609
            ...|.||:           |||:::          |.|.|.||.|     |.|...:|...||..
Frog   157 FPTATVAT-----------LPGLTTAPPAGGVFKLPLANLQAASL-----LNTALQAPMQAAQAI 205

  Fly   610 QLLQQRQVALTQQ------------------------------------------------FN-- 624
            |.:.|.|.||..|                                                ||
Frog   206 QTVYQTQPALQAQPSLQTAVQPMTTLQAASPLQGQTAVLPGTLQKAAEPQSQITVQPASFTFNPA 270

  Fly   625 --------SYMELLRS------------------------------GSLGLAQDDPALTAQVAAA 651
                    ...:||.|                              |:|....:.|.:||..|.|
Frog   271 IISAASLGGQAQLLGSLAATPIIANAIPGVQGITSQIITNTQGQVIGTLPWLLNSPGITAGAATA 335

  Fly   652 QFLMQSQLQALSQASQQLQALQKQQQRQV----DEPLQLNHKMTQQPRSSTPHSIRSPIAIRSPA 712
            ....|:.:|.::.     |.|...|.:.:    ..|:|......|.|:.|..|           .
Frog   336 AVSAQNLVQTVTP-----QLLLNAQGQVIATLASSPIQQGAVRKQTPQDSPAH-----------P 384

  Fly   713 SSPQQLHHHHHHPLQITPPSSAASLKLSGMLTPSTPTSGTQMSQGTTTPQPKTVASAAAARAAGE 777
            .|.||:       :|.||..:..|:.::   .|:.||:.|......:..:|.||....:...:|.
Frog   385 KSEQQV-------IQPTPAITQPSVVVA---NPAPPTTSTSTQVHISCSEPPTVGQLVSKAHSGN 439

  Fly   778 PSPEETTDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCK 842
             ..::..:|||:.:|||.||.||:.||.||..||.|:....|..:||:.|.|||.|:::.|:..|
Frog   440 -YDDDGINLEEIREFAKEFKIRRLSLGLTQTQVGQALTATEGPAYSQSAICRFEKLDITPKSAQK 503

  Fly   843 LKPLLQKWLDDADRTIQATGGVFDPAALQATVSTPEIIG----RRRKKRTSIETTIRGALEKAFL 903
            |||:|:|||::|:...|           :...:..|.:|    ::||:|||........|...|.
Frog   504 LKPVLEKWLNEAEMRNQ-----------EGQQNLMEFVGGEPSKKRKRRTSFTPQAVEVLNAYFE 557

  Fly   904 ANQKPTSEEITQLADRLSMEKEVVRVWFCNRRQKEK 939
            .|..|..:|||.:|..|:.::||||||||||||..|
Frog   558 KNSLPAGQEITDIAKELNYDREVVRVWFCNRRQTLK 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nub	NP_001097153.1	DUF4472	315..>399	CDD:291409
		POU	791..855	CDD:197673	31/63 (49%)
		Homeobox	886..939	CDD:278475	24/52 (46%)
pou6f1	XP_012811781.1	POU	442..516	CDD:197673	34/73 (47%)
pou6f1	XP_012811781.1	Homeobox	540..594	CDD:395001	25/54 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910