DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ref2 and Alyref2

DIOPT Version :9

Sequence 1:	NP_001246007.1	Gene:	Ref2 / 34667	FlyBaseID:	FBgn0032439	Length:	220	Species:	Drosophila melanogaster
Sequence 2:	NP_062357.3	Gene:	Alyref2 / 56009	MGIID:	1913144	Length:	218	Species:	Mus musculus

Alignment Length:	208	Identity:	69/208 - (33%)
Similarity:	96/208 - (46%)	Gaps:	45/208 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSDKMKMSLDDIIKMKFNKNKFVNAKNERVQGGSIRKRNSEGGLRGIQRSRNGTGFIRKSKFKQE 65
            |:|||.||||||||:  |:|:              |:.|..||.|     ||.....|..:.:..
Mouse     1 MADKMDMSLDDIIKL--NRNQ--------------RRVNRGGGPR-----RNRPAIARGGRNRPA 44

  Fly    66 TLLKPPKKP---------------------TLVMVCNLDYGVDDDDIMELFNQDGVVEKGFVHYD 109
            ...:|...|                     ..::|.|||:||.|.||.|||.:.|.::|..|.||
Mouse    45 PYSRPKPLPDKWQHDLFDSGCGGGEGVETGAKLLVSNLDFGVSDADIQELFAEFGTLKKAAVDYD 109

  Fly   110 RDGNSLGTAHLSFKYREEAFQIIEQFHGVRLDGRRLKLHLVQNTRNFKRTDVDDLSLRMGSFKTR 174
            |.|.|||||.:.|:.|.:|.:.::|:.||.||||.:.:.||.:..:.:|....  |...|.. ||
Mouse   110 RSGRSLGTADVHFERRADALKAMKQYKGVPLDGRPMDIQLVTSQIDPQRRPAQ--SGNRGGM-TR 171

  Fly   175 FLQNGTFKTRSLQ 187
            ...:|.|..|..|
Mouse   172 SRGSGGFGGRGSQ 184

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ref2	NP_001246007.1	RRM	2..>198	CDD:223796	68/207 (33%)
Ref2	NP_001246007.1	RRM_SF	75..149	CDD:302621	34/73 (47%)
Alyref2	NP_062357.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55		24/74 (32%)
		FYTT	3..>32	CDD:284488	19/49 (39%)
		Sufficient for RNA-binding, interaction with NXF1-NXT1	16..37		9/39 (23%)
		Interaction with HHV-8 ORF57 protein and with ICP27 from HHV-1	54..155		36/100 (36%)
		RRM	<75..>157	CDD:223796	36/81 (44%)
		RRM_THOC4	75..149	CDD:241124	34/73 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..218		9/37 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0533
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001223
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101458
Panther	1	1.100	-	-	O	PTHR19965
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.770