DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ref2 and ALYREF

DIOPT Version :9

Sequence 1:	NP_001246007.1	Gene:	Ref2 / 34667	FlyBaseID:	FBgn0032439	Length:	220	Species:	Drosophila melanogaster
Sequence 2:	NP_005773.3	Gene:	ALYREF / 10189	HGNCID:	19071	Length:	264	Species:	Homo sapiens

Alignment Length:	207	Identity:	64/207 - (30%)
Similarity:	100/207 - (48%)	Gaps:	36/207 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSDKMKMSLDDIIKMKFNKNKFVNAKNERVQGGSIRKRNSEGGLRGIQRSRNGTGFIRK------ 59
            |:|||.||||||||:  |:::.......|.:|.:..:....||.:...|...|.|.||.
Human     8 MADKMDMSLDDIIKL--NRSQRGGRGGGRGRGRAGSQGGRGGGAQAAARVNRGGGPIRNRPAIAR 70

  Fly    60 ------SKFKQETLLKPPKKPT---------------------LVMVCNLDYGVDDDDIMELFNQ 97
                  .:.:.....:|.:.|.                     .::|.|||:||.|.||.|||.:
Human    71 GAAGGGGRNRPAPYSRPKQLPDKWQHDLFDSGFGGGAGVETGGKLLVSNLDFGVSDADIQELFAE 135

  Fly    98 DGVVEKGFVHYDRDGNSLGTAHLSFKYREEAFQIIEQFHGVRLDGRRLKLHLVQNTRNFKRTDVD 162
            .|.::|..|||||.|.|||||.:.|:.:.:|.:.::|::||.||||.:.:.||.:..:.:|....
Human   136 FGTLKKAAVHYDRSGRSLGTADVHFERKADALKAMKQYNGVPLDGRPMNIQLVTSQIDAQRRPAQ 200

  Fly   163 DLSLRMGSFKTR 174
            .:: |.|..:.|
Human   201 SVN-RGGMTRNR 211

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ref2	NP_001246007.1	RRM	2..>198	CDD:223796	63/206 (31%)
Ref2	NP_001246007.1	RRM_SF	75..149	CDD:302621	34/94 (36%)
ALYREF	NP_005773.3	FYTT	4..>23	CDD:284488	12/16 (75%)
		RRM	<114..>210	CDD:223796	39/96 (41%)
		RRM_THOC4	114..187	CDD:241124	34/72 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0533
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1369069at2759
OrthoFinder	1	1.000	-	-		FOG0001223
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101458
Panther	1	1.100	-	-	O	PTHR19965
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.780