DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bun and TSC22D4

DIOPT Version :9

Sequence 1:	NP_001036357.2	Gene:	bun / 34665	FlyBaseID:	FBgn0259176	Length:	1331	Species:	Drosophila melanogaster
Sequence 2:	NP_001289972.1	Gene:	TSC22D4 / 81628	HGNCID:	21696	Length:	395	Species:	Homo sapiens

Alignment Length:	416	Identity:	116/416 - (27%)
Similarity:	141/416 - (33%)	Gaps:	139/416 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   933 GGNRKRAFSNPHI----GGPNDPSFMHRLNPQLYYYNKSQSGRSSFCVDESLWPTNNPNGAVS-D 992
            ||.:|.:|....:    .||..|.......||      ..:|.          |...|||..| |
Human     3 GGKKKSSFQITSVTTDYEGPGSPGASDPPTPQ------PPTGP----------PPRLPNGEPSPD 51

  Fly   993 TNLYMGSSTDEDYEEAIDQFSPTIYTTRSASRAIPIPNSAGSSPQHQMH-------------HSQ 1044
            ..   |..|..:       .||......|..|.:.:|:..| .|..:..             ||.
Human    52 PG---GKGTPRN-------GSPPPGAPSSRFRVVKLPHGLG-EPYRRGRWTCVDVYERDLEPHSF 105

  Fly  1045 PRIAIGINQMEG------------------GGPTRSTGAFSASPSIYAYP--------------- 1076
            ..:..||....|                  |.||..:| .|..|:.:..|
Human   106 GGLLEGIRGASGGAGGRSLDSRLELASLGLGAPTPPSG-LSQGPTSWLRPPPTSPGPQARSFTGG 169

  Fly  1077 -------------HSPFYASS-----PETSFGSAA---MPGHPAASSRI------SFSYDPAFQR 1114
                         ..|..|||     ||...|.:|   ....|..|.|:      |.:..|...|
Human   170 LGQLVVPSKAKAEKPPLSASSPQQRPPEPETGESAGTSRAATPLPSLRVEAEAGGSGARTPPLSR 234

  Fly  1115 -----------LQVPNASG-----DRRPRSPL-----------ECASVFAAVAA----AATCGDA 1148
                       |..|...|     |.||.||.           :....|.||||    .|....|
Human   235 RKAVDMRLRMELGAPEEMGQVPPLDSRPSSPALYFTHDASLVHKSPDPFGAVAAQKFSLAHSMLA 299

  Fly  1149 AGGAADTVISSASGTSAVAIDNKIEQAMDLVKSHLMIAVREEVEVLKERISELMDKINKLELENS 1213
            ..|..|:...|.|| |.|.|||||||||||||||||.|||||||||||:|.||.::...||.||.
Human   300 ISGHLDSDDDSGSG-SLVGIDNKIEQAMDLVKSHLMFAVREEVEVLKEQIRELAERNAALEQENG 363

  Fly  1214 ILKSNIPQETLQQLQLQ-LQLAAPPA 1238
            :|::....|.|.||... :....|||
Human   364 LLRALASPEQLAQLPSSGVPRLGPPA 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bun	NP_001036357.2	TSC22	1176..1223	CDD:279505	28/46 (61%)
TSC22D4	NP_001289972.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..86		25/109 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	103..237		26/134 (19%)
		Med4	<137..224	CDD:287038	17/87 (20%)
		TSC22	326..380	CDD:307358	32/53 (60%)
		Leucine-zipper	344..365		10/20 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	376..395		5/14 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154583
Domainoid	1	1.000	70	1.000	Domainoid score	I9543
eggNOG	1	0.900	-	-		E1_KOG4797
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001302
OrthoInspector	1	1.000	-	-		otm42281
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2903
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.770